Gene Summary

Name:
arrestin 3, retinal
Synonyms:
arrestin 4,  X-arrestin,  CAR,  mCARFL,  Arr4,  mCAR,  cone arrestin

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
impaired pupillary reflex Arr3em1(IMPC)J HEM Early adult 2.93×10-07
increased circulating alkaline phosphatase level Arr3em1(IMPC)J HOM Early adult 2.19×10-05
decreased circulating triglyceride level Arr3em1(IMPC)J HOM Early adult 3.99×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

7 Images

Human diseases caused by Arr3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Arr3 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Myopia 26, X-Linked, Female-Limited
OMIM:301010

The table below shows human diseases predicted to be associated to Arr3 by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Arr3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Arr3.

No publications found that use IMPC mice or data for Arr3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Arr3tm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Arr3em1(IMPC)J Exon Deletion Mice
Arr3tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Arr3tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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