Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
rad and gem related GTP binding protein 2
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rem2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rem2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Progressive Supranuclear Palsy
Abnormality of eye movement, Vertical supranuclear gaze palsy, Supranuclear gaze palsy, Supranucl... ORPHA:683

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rem2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rem2.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Experience-Dependent Development of Dendritic Arbors in Mouse Visual Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience (July 2020) Rem2tm1a(EUCOMM)Hmgu 32669356
Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits. eLife (May 2018) Rem2tm1a(EUCOMM)Hmgu PMC6010341

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Rem2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Rem2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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