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Gene: Muc4 MGI:2153525

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
mucin 4
Synonyms:
4933405I11Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Muc4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Muc4 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Human Coronavirus Sensitivity
Susceptibility to coronavirus 229e OMIM:122460
Leishmaniasis, Tegumentary, Susceptibility To
Tegumentary leishmaniasis susceptibility OMIM:602068
Varicella, Severe Recurrent
Severe recurrent varicella OMIM:600670
Coxsackievirus B3 Susceptibility
Recurrent viral infections OMIM:120050
Ciliary Discoordination Due To Random Ciliary Orientation
Recurrent infections OMIM:215518
Immunodeficiency 30
Recurrent infections, Recurrent mycobacterial infections OMIM:614891
Tracheopathia Osteoplastica
Recurrent pneumonia, Cough, Wheezing, Dyspnea OMIM:189961
Pulmonary Blastoma
Recurrent pneumonia, Dyspnea, Weight loss, Cough ORPHA:64741
Immunodeficiency 34
Severe recurrent varicella, Recurrent mycobacterial infections OMIM:300645
Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome
Recurrent infections, Respiratory distress ORPHA:171703
Bardet-Biedl Syndrome 16
Recurrent otitis media, Bronchiolitis, Obesity, Recurrent respiratory infections, Respiratory dis... OMIM:615993
Laryngeal Web, Familial
Stridor, Recurrent upper respiratory tract infections, Respiratory distress OMIM:150360
Interstitial Pneumonitis, Desquamative, Familial
Recurrent upper respiratory tract infections, Tachypnea, Respiratory failure, Cough, Failure to t... OMIM:263000
Neutrophil Actin Dysfunction
Recurrent bacterial infections OMIM:257150
Isolated Congenital Hypoglossia/Aglossia
Dyspnea, Upper airway obstruction, Respiratory distress, Aspiration pneumonia, Weight loss ORPHA:141152
Ciliary Dyskinesia, Primary, 47, And Lissencephaly
Bronchiectasis, Atelectasis, Recurrent respiratory infections, Abnormal mucociliary clearance, Re... OMIM:619466
Emphysema, Congenital Lobar
Respiratory distress OMIM:130710
Recurrent Respiratory Papillomatosis
Nonproductive cough, Recurrent pneumonia, Recurrent upper respiratory tract infections, Tracheoma... ORPHA:60032
Hypomyelination Neuropathy-Arthrogryposis Syndrome
Respiratory distress ORPHA:2680
Bronchopulmonary Dysplasia
Abnormal respiratory system physiology, Emphysema, Respiratory failure requiring assisted ventila... ORPHA:70589
Pulmonary Non-Tuberculous Mycobacterial Infection
Disseminated nontuberculous mycobacterial infection, Crackles, Cough, Pleural effusion, Bronchiec... ORPHA:411703
Familial Nasal Acilia
Recurrent upper respiratory tract infections, Chronic rhinitis, Dyspnea, Atelectasis, Bronchiecta... ORPHA:922
Combined Oxidative Phosphorylation Deficiency 19
Failure to thrive, Respiratory distress OMIM:615595
Idiopathic Bronchiectasis
Abnormal respiratory system physiology, Emphysema, Reduced FEV1/FVC ratio, Crackles, Acute infect... ORPHA:60033
Gaucher Disease Type 2
Recurrent respiratory infections, Abnormal pattern of respiration, Respiratory distress, Cough ORPHA:77260
Growth Hormone Insensitivity Syndrome With Immune Dysregulation 1, Autosomal Recessive
Lymphocytic interstitial pneumonia, Failure to thrive, Respiratory distress OMIM:245590
Epilepsy, Pyridoxine-Dependent
Neonatal respiratory distress, Respiratory distress OMIM:266100
Chronic Pneumonitis Of Infancy
Hypoxemia, Tachypnea, Reduced forced vital capacity, Cough, Failure to thrive, Hyperventilation, ... ORPHA:91359
Hereditary Pulmonary Alveolar Proteinosis
Respiratory failure requiring assisted ventilation, Restrictive ventilatory defect, Hypoxemia, Fa... ORPHA:264675
Laryngotracheal Angioma
Cough, Stridor, Respiratory distress, Apnea, Intercostal retractions, Wheezing ORPHA:137935
Pleural Mesothelioma
Abnormal respiratory system physiology, Pleural effusion, Cough, Dyspnea, Respiratory distress, W... ORPHA:50251
Respiratory Distress Syndrome In Premature Infants
Tachypnea, Dyspnea, Atelectasis, Respiratory distress, Neonatal respiratory distress OMIM:267450
Succinic Acidemia
Respiratory distress OMIM:600335
Cryptogenic Organizing Pneumonia
Nonproductive cough, Restrictive ventilatory defect, Hypoxemia, Bronchial breath sound, Crackles,... ORPHA:1302
Myopathy, Congenital, With Fiber-Type Disproportion, X-Linked
Respiratory insufficiency due to muscle weakness, Decreased body weight, Respiratory distress OMIM:300580
Severe Acute Respiratory Syndrome
Respiratory failure requiring assisted ventilation, Hypoxemia, Cough, Dyspnea, Chronic lung disea... ORPHA:140896
Congenital Lobar Emphysema
Emphysema, Respiratory distress ORPHA:1928
Myasthenic Syndrome, Congenital, 6, Presynaptic
Respiratory insufficiency due to muscle weakness, Apneic episodes precipitated by illness, fatigu... OMIM:254210
Mitochondrial Dna Depletion Syndrome, Myopathic Form
Recurrent pneumonia, Failure to thrive in infancy, Respiratory failure, Respiratory insufficiency... ORPHA:254875
Perching Syndrome
Respiratory distress OMIM:617055
Laryngomalacia
Congenital laryngeal stridor, Respiratory distress OMIM:150280
Nipah Virus Disease
Infectious encephalitis, Recurrent pharyngitis, Cough, Respiratory distress ORPHA:99825
Surfactant Metabolism Dysfunction, Pulmonary, 2
Recurrent pneumonia, Nonspecific interstitial pneumonia, Hypoxemia, Tachypnea, Interstitial pneum... OMIM:610913
Ciliary Dyskinesia, Primary, 2
Immotile cilia, Sinusitis, Ciliary dyskinesia, Bronchiectasis, Recurrent respiratory infections, ... OMIM:606763
Myasthenic Syndrome, Congenital, 4A, Slow-Channel
Respiratory insufficiency due to muscle weakness, Apneic episodes precipitated by illness, fatigu... OMIM:605809
Developmental And Epileptic Encephalopathy 30
Respiratory distress OMIM:616341
Cardiomyopathy-Hypotonia-Lactic Acidosis Syndrome
Failure to thrive, Respiratory distress ORPHA:91130
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset
Restrictive ventilatory defect, Respiratory failure, Failure to thrive, Respiratory distress, Res... OMIM:614399
Staphylococcal Necrotizing Pneumonia
Nonproductive cough, Pneumonia, Hypoxemia, Severe infection, Tachypnea, Respiratory failure, Coug... ORPHA:36238
Acute Lung Injury
Pneumonia, Hypoxemia, Tachypnea, Respiratory failure, Dyspnea, Sepsis, Respiratory distress ORPHA:178320
Bronchiolitis Obliterans With Obstructive Pulmonary Disease
Nonproductive cough, Reduced FEV1/FVC ratio, Hypoxemia, Pneumonia, Airway obstruction, Reduced fo... ORPHA:1303
Intellectual Developmental Disorder With Speech Delay And Axonal Peripheral Neuropathy
Respiratory distress OMIM:619099
Pneumocystosis
Nonproductive cough, Respiratory failure requiring assisted ventilation, Hypoxemia, Interstitial ... ORPHA:723
Lethal Osteosclerotic Bone Dysplasia
Respiratory failure, Respiratory distress, Dyspnea ORPHA:1832
Severe X-Linked Mitochondrial Encephalomyopathy
Respiratory insufficiency, Respiratory distress ORPHA:238329
Infant Acute Respiratory Distress Syndrome
Pneumonia, Hypoxemia, Tachypnea, Respiratory failure, Atelectasis, Sepsis, Nasal flaring ORPHA:70587
X-Linked Centronuclear Myopathy
Recurrent respiratory infections, Respiratory failure requiring assisted ventilation, Pneumonia, ... ORPHA:596
Congenital Disorder Of Glycosylation, Type Iy
Failure to thrive, Respiratory distress OMIM:300934
Short Chain Acyl-Coa Dehydrogenase Deficiency
Failure to thrive, Respiratory distress ORPHA:26792
N-Acetylglutamate Synthase Deficiency
Failure to thrive, Respiratory distress OMIM:237310
Laryngotracheoesophageal Cleft
Aspiration, Cough, Dyspnea, Recurrent respiratory infections, Stridor, Neonatal respiratory distress ORPHA:2004
Congenital Laryngeal Web
Stridor, Respiratory distress ORPHA:2374
Choanal Atresia
Tracheomalacia, Abnormal nasal mucus secretion, Recurrent respiratory infections, Upper airway ob... ORPHA:137914
Respiratory Bronchiolitis-Interstitial Lung Disease Syndrome
Emphysema, Nonproductive cough, Restrictive ventilatory defect, Reduced FEV1/FVC ratio, Hypoxemia... ORPHA:79127
Pulmonary Alveolar Proteinosis, Acquired
Restrictive ventilatory defect, Pneumonia, Hypoxemia, Cough, Dyspnea, Recurrent respiratory infec... OMIM:610910
Anaplastic Thyroid Carcinoma
Cough, Dyspnea, Stridor, Upper airway obstruction, Respiratory distress, Weight loss ORPHA:142
Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
Restrictive ventilatory defect, Hypoxemia, Oxygen desaturation on exertion, Asthma, Crackles, Tac... OMIM:610978
Inhalational Anthrax
Sepsis, Respiratory distress, Dyspnea ORPHA:247257
Idiopathic Neonatal Atrial Flutter
Large for gestational age, Tachypnea, Respiratory distress ORPHA:45452
Chitayat Syndrome
Recurrent respiratory infections, Tracheomalacia, Respiratory distress OMIM:617180
Brown-Vialetto-Van Laere Syndrome 1
Nocturnal hypoventilation, Dyspnea, Recurrent respiratory infections, Stridor, Respiratory distre... OMIM:211530
Imperforate Oropharynx-Costovertebral Anomalies Syndrome
Recurrent respiratory infections, Respiratory failure, Respiratory distress, Dyspnea ORPHA:2759
Mitochondrial Complex Iv Deficiency, Nuclear Type 2
Respiratory distress OMIM:604377
Encephalopathy, Acute, Infection-Induced, Susceptibility To, 9
Failure to thrive, Respiratory distress OMIM:618426
Surfactant Metabolism Dysfunction, Pulmonary, 3
Paraseptal emphysema, Nonspecific interstitial pneumonia, Hypoxemia, Tachypnea, Respiratory failu... OMIM:610921
Meconium Aspiration Syndrome
Hypoxemia, Atelectasis, Pulmonary arterial hypertension, Neonatal asphyxia, Pneumothorax, Respira... ORPHA:70588
Nasolacrimal Duct Cyst
Recurrent infections, Abnormal breath sound, Paroxysmal dyspnea, Episodic respiratory distress, S... ORPHA:141083
Mitochondrial Myopathy With Reversible Cytochrome C Oxidase Deficiency
Respiratory failure requiring assisted ventilation, Respiratory distress, Ventilator dependence w... ORPHA:254864
Leukodystrophy, Hypomyelinating, 17
Respiratory distress OMIM:618006
Malaria
Respiratory distress ORPHA:673
Avian Influenza
Nonproductive cough, Pneumonia, Hypoxemia, Infectious encephalitis, Tachypnea, Respiratory failur... ORPHA:454836
Stt3B-Cdg
Failure to thrive, Respiratory distress ORPHA:370924
Thyroid Lymphoma
Stridor, Upper airway obstruction, Respiratory distress, Dyspnea ORPHA:97285
Chronic Beryllium Disease
Abnormal respiratory system physiology, Reduced FEV1/FVC ratio, Abnormality on pulmonary function... ORPHA:133
Coenzyme Q10 Deficiency, Primary, 8
Respiratory distress, Small for gestational age OMIM:616733
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut0
Sepsis, Respiratory distress ORPHA:289916
Congenital Pulmonary Lymphangiectasia
Pleural effusion, Cough, Pulmonary arterial hypertension, Chronic pulmonary obstruction, Respirat... ORPHA:2414
Congenital Disorder Of Glycosylation, Type Ix
Failure to thrive, Respiratory distress OMIM:615597
Tularemia
Pneumonia, Pleural effusion, Meningitis, Cough, Respiratory distress, Brain abscess ORPHA:3392
Mitochondrial Pyruvate Carrier Deficiency
Respiratory distress OMIM:614741
Developmental And Epileptic Encephalopathy 68
Failure to thrive, Respiratory distress OMIM:618201
Paternal 20Q13.2Q13.3 Microdeletion Syndrome
Failure to thrive, Respiratory distress ORPHA:261304
Lethal Recessive Chondrodysplasia
Respiratory distress ORPHA:1423
Progressive Supranuclear Palsy-Parkinsonism Syndrome
Respiratory distress ORPHA:240085
Myopathy And Diabetes Mellitus
Respiratory distress ORPHA:2596
Congenital Diaphragmatic Hernia
Hypoxemia, Respiratory distress ORPHA:2140
Rnf13-Related Severe Early-Onset Epileptic Encephalopathy
Failure to thrive, Sepsis, Respiratory distress ORPHA:544503
Congenital Tracheomalacia
Emphysema, Recurrent upper respiratory tract infections, Decreased peak expiratory flow, Tracheom... ORPHA:95430
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema
Upper airway obstruction, Respiratory distress ORPHA:100057
Congenital Disorder Of Glycosylation, Type Iu
Neonatal respiratory distress, Respiratory distress OMIM:615042
Holocarboxylase Synthetase Deficiency
Tachypnea, Weight loss, Respiratory distress ORPHA:79242
Pomt1-Related Limb-Girdle Muscular Dystrophy R11
Cough, Respiratory distress, Dyspnea ORPHA:86812
Congenital Muscular Dystrophy With Intellectual Disability And Severe Epilepsy
Recurrent respiratory infections, Failure to thrive, Respiratory distress ORPHA:329178
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut-
Failure to thrive, Respiratory distress ORPHA:79312
Folinic Acid-Responsive Seizures
Apnea, Respiratory distress ORPHA:79097
Diaphanospondylodysostosis
Respiratory distress ORPHA:66637
Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To 5Q31.3 Microdeletion
Apnea, Recurrent pneumonia, Respiratory distress, Hypoventilation, Aspiration pneumonia ORPHA:314655
Synaptic Congenital Myasthenic Syndromes
Neonatal respiratory distress, Sleep apnea, Respiratory insufficiency, Pulmonary arterial hyperte... ORPHA:98915
Slc35A1-Cdg
Pneumonia, Hypoxemia, Respiratory distress ORPHA:238459
Progressive Supranuclear Palsy-Corticobasal Syndrome
Respiratory distress ORPHA:240103
Neurogenic Arthrogryposis Multiplex Congenita
Respiratory insufficiency due to muscle weakness, Respiratory distress ORPHA:1143
Congenital Disorder Of Glycosylation, Type Ie
Failure to thrive, Respiratory distress OMIM:608799
Hypoglossia With Situs Inversus
Upper airway obstruction, Respiratory distress OMIM:612776
Shwachman-Diamond Syndrome 1
Recurrent infections, Small for gestational age, Failure to thrive, Respiratory distress, Neonata... OMIM:260400
Nocardiosis
Emphysema, Nonproductive cough, Weight loss, Pneumonia, Severe infection, Infectious encephalitis... ORPHA:31204
Sepsis In Premature Infants
Abnormal respiratory system physiology, Decreased body weight, Small for gestational age, Severe ... ORPHA:90051
Biotinidase Deficiency
Recurrent viral infections, Recurrent fungal infections, Hyperventilation, Respiratory distress, ... ORPHA:79241
Multiple Carboxylase Deficiency
Tachypnea, Respiratory distress ORPHA:148
Primary Dystonia, Dyt4 Type
Respiratory distress, Eunuchoid habitus ORPHA:98805
Spinocerebellar Ataxia, X-Linked 3
Episodic respiratory distress, Recurrent respiratory infections, Episodic hypoventilation OMIM:301790
Acquired Methemoglobinemia
Hypoxemia, Respiratory distress, Dyspnea ORPHA:464453
Odontochondrodysplasia 1
Recurrent respiratory infections, Respiratory distress OMIM:184260
Infantile Krabbe Disease
Recurrent infections, Respiratory failure, Failure to thrive, Cachexia, Respiratory distress ORPHA:206436
Hyperparathyroidism, Transient Neonatal
Respiratory distress OMIM:618188
Kniest Dysplasia
Recurrent otitis media, Tracheomalacia, Respiratory distress OMIM:156550
Tetrasomy 5P
Pulmonary arterial hypertension, Recurrent respiratory infections, Failure to thrive, Respiratory... ORPHA:3309
Oromandibular Dystonia
Weight loss, Respiratory distress ORPHA:93958
Infantile-Onset X-Linked Spinal Muscular Atrophy
Respiratory insufficiency, Respiratory distress ORPHA:1145
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
Failure to thrive, Respiratory distress ORPHA:927
Congenital Enterovirus Infection
Infectious encephalitis, Pleural effusion, Meningitis, Sepsis, Respiratory distress ORPHA:292
Oculocerebrofacial Syndrome, Kaufman Type
Failure to thrive, Respiratory failure, Respiratory distress, Dyspnea ORPHA:2707
Congenital Myasthenic Syndrome
Central sleep apnea, Episodic respiratory distress, Recurrent respiratory infections, Obstructive... ORPHA:590
Presynaptic Congenital Myasthenic Syndromes
Central sleep apnea, Episodic respiratory distress, Recurrent respiratory infections, Obstructive... ORPHA:98914
Bacterial Toxic-Shock Syndrome
Sinusitis, Pneumonia, Severe infection, Infectious encephalitis, Tachypnea, Severe varicella zost... ORPHA:36234
Brain-Lung-Thyroid Syndrome
Recurrent pneumonia, Asthma, Respiratory failure, Pulmonary arterial hypertension, Recurrent resp... ORPHA:209905
Mitochondrial Complex I Deficiency, Nuclear Type 37
Pulmonary arterial hypertension, Failure to thrive, Respiratory distress OMIM:619272
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Large for gestational age, Respiratory distress ORPHA:226313
Complete Atrioventricular Septal Defect
Recurrent pneumonia, Crackles, Tachypnea, Elevated pulmonary artery pressure, Failure to thrive, ... ORPHA:1329
Surfactant Metabolism Dysfunction, Pulmonary, 5
Exertional dyspnea, Respiratory insufficiency, Dyspnea OMIM:614370
Surfactant Metabolism Dysfunction, Pulmonary, 1
Tachypnea, Respiratory failure, Dyspnea, Pulmonary arterial hypertension, Failure to thrive, Neon... OMIM:265120
Pulmonary Hypertension, Primary, 3
Pulmonary arterial hypertension, Elevated pulmonary artery pressure, Increased pulmonary vascular... OMIM:615343
Mitochondrial Complex Iv Deficiency, Nuclear Type 1
Exertional dyspnea, Failure to thrive, Respiratory insufficiency due to muscle weakness, Respirat... OMIM:220110
Fructose-1,6-Bisphosphatase Deficiency
Apneic episodes in infancy, Episodic tachypnea, Dyspnea, Respiratory distress, Intermittent hyper... ORPHA:348
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Pneumonia, Small for gestational age, Episodic tachypnea, Obesity, Tachypnea, Overweight, Respira... ORPHA:26793
Lissencephaly Syndrome, Norman-Roberts Type
Respiratory distress ORPHA:89844
Mercury Poisoning
Respiratory failure, Interstitial pneumonitis, Respiratory distress, Dyspnea ORPHA:330021
Mucopolysaccharidosis-Plus Syndrome
Recurrent pneumonia, Recurrent respiratory infections, Sepsis, Respiratory distress, Recurrent br... OMIM:617303
Neurodevelopmental Disorder With Hypotonia, Facial Dysmorphism, And Brain Abnormalities
Recurrent respiratory infections, Respiratory distress OMIM:619383
Odontochondrodysplasia
Respiratory distress ORPHA:166272
Short-Rib Thoracic Dysplasia 16 With Or Without Polydactyly
Respiratory distress OMIM:617102
Microlissencephaly-Micromelia Syndrome
Failure to thrive, Respiratory distress ORPHA:50810
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Recurrent infections, Pneumonia, Failure to thrive in infancy, Interstitial pneumonitis, Meningit... ORPHA:37042
Q Fever
Pneumonia, Unusual infection, Infectious encephalitis, Cough, Meningitis, Pleural effusion, Respi... ORPHA:781
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Respiratory insufficiency, Failure to thrive, Respiratory distress ORPHA:367
Episodic Ataxia Type 1
Respiratory distress ORPHA:37612
Glycogen Storage Disease Due To Acid Maltase Deficiency, Infantile Onset
Respiratory failure requiring assisted ventilation, Respiratory failure, Failure to thrive, Respi... ORPHA:308552
Leigh Syndrome With Cardiomyopathy
Respiratory failure, Failure to thrive, Respiratory distress, Apnea, Central hypoventilation ORPHA:70474
Toxic Epidermal Necrolysis
Restrictive ventilatory defect, Cough, Recurrent respiratory infections, Sepsis, Respiratory dist... ORPHA:537
Short-Rib Thoracic Dysplasia 19 With Or Without Polydactyly
Respiratory failure, Respiratory distress OMIM:617895
Esophageal Atresia
Restrictive ventilatory defect, Small for gestational age, Aspiration, Failure to thrive in infan... ORPHA:1199
Farber Disease
Recurrent upper respiratory tract infections, Atelectasis, Failure to thrive, Respiratory distres... ORPHA:333
Cryptococcosis
Pneumonia, Pleural effusion, Meningitis, Cough, Dyspnea, Sepsis, Respiratory distress ORPHA:1546
Myotonic Dystrophy 1
Respiratory distress OMIM:160900
Tetanus
Tachypnea, Respiratory distress ORPHA:3299
Triosephosphate Isomerase Deficiency
Respiratory failure, Failure to thrive, Respiratory insufficiency due to muscle weakness, Respira... OMIM:615512
Myotubular Myopathy With Abnormal Genital Development
Atelectasis, Respiratory distress OMIM:300219
Methylmalonic Aciduria, Cblb Type
Failure to thrive, Respiratory distress OMIM:251110
Craniofaciofrontodigital Syndrome
Large for gestational age, Pulmonary arterial hypertension, Respiratory distress, Dyspnea ORPHA:363705
Lymphatic Malformation 7
Respiratory distress OMIM:617300
Moebius Syndrome
Respiratory distress OMIM:157900
Methylmalonic Aciduria, Cbla Type
Failure to thrive, Respiratory distress OMIM:251100
Oculopharyngodistal Myopathy 1
Restrictive ventilatory defect, Aspiration, Hypercapnia, Reduced forced vital capacity, Respirato... OMIM:164310
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Airway obstruction, Pulmonary arterial hypertension, Recurrent respiratory infections, Stridor, R... ORPHA:505248
Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis
Respiratory distress OMIM:606164
Radio-Renal Syndrome
Chylothorax, Respiratory failure, Pleural effusion, Dyspnea, Respiratory distress ORPHA:3015
Diaphanospondylodysostosis
Respiratory insufficiency, Tracheomalacia, Respiratory distress OMIM:608022
Mgat2-Cdg
Failure to thrive, Respiratory distress, Recurrent upper and lower respiratory tract infections ORPHA:79329
Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis
Respiratory distress, Failure to thrive in infancy OMIM:612852
Lujo Hemorrhagic Fever
Nonproductive cough, Crackles, Atelectasis, Rhinitis, Severe viral infection, Respiratory distress ORPHA:319213
Gaucher Disease, Perinatal Lethal
Apnea, Decreased body weight, Respiratory distress OMIM:608013
Congenital Disorder Of Deglycosylation 1
Recurrent respiratory infections, Decreased body weight, Central sleep apnea, Respiratory distress OMIM:615273
Spinal muscular atrophy, type I, with congenital bone fractures
Respiratory distress OMIM:271225
Pachyonychia Congenita
Failure to thrive, Respiratory distress ORPHA:2309
Severe Generalized Junctional Epidermolysis Bullosa
Pneumonia, Respiratory failure, Dyspnea, Failure to thrive, Stridor, Recurrent urinary tract infe... ORPHA:79404
Intellectual Developmental Disorder, X-Linked 99, Syndromic, Female-Restricted
Recurrent respiratory infections, Respiratory distress OMIM:300968
Japanese Encephalitis
Infectious encephalitis, Irregular respiration, Abnormal pattern of respiration, Meningitis, Resp... ORPHA:79139
Hemorrhagic Fever-Renal Syndrome
Decreased body weight, Pneumonia, Severe infection, Respiratory failure, Cough, Pleural effusion,... ORPHA:340
Agnathia-Otocephaly Complex
Tracheomalacia, Respiratory distress OMIM:202650
Microcephaly-Seizures-Intellectual Disability-Heart Disease Syndrome
Pulmonary arterial hypertension, Respiratory distress ORPHA:2519
Glycogen Storage Disease Due To Acid Maltase Deficiency
Sleep apnea, Respiratory failure, Atelectasis, Exertional dyspnea, Failure to thrive, Respiratory... ORPHA:365
Corpus Callosum, Agenesis Of, With Facial Anomalies And Robin Sequence
Neonatal respiratory distress, Tracheomalacia, Respiratory distress OMIM:217980
Auriculocondylar Syndrome
Obstructive sleep apnea, Snoring, Respiratory distress ORPHA:137888
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Respiratory distress ORPHA:990
Listeriosis
Pneumonia, Unusual skin infection, Infectious encephalitis, Respiratory failure, Meningitis, Seps... ORPHA:533
Ramos-Arroyo Syndrome
Severe failure to thrive, Decreased body weight, Respiratory distress ORPHA:1051
Rodrigues Blindness
Nasal flaring OMIM:268320
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Apnea, Recurrent respiratory infections, Failure to thrive, Respiratory distress ORPHA:17
Hereditary Angioedema Type 1
Inspiratory stridor, Respiratory distress, Dyspnea ORPHA:100050
Adnp Syndrome
Recurrent upper respiratory tract infections, Aspiration, Truncal obesity, Recurrent urinary trac... ORPHA:404448
Campomelic Dysplasia
Recurrent upper respiratory tract infections, Tracheomalacia, Neonatal respiratory distress, Fail... OMIM:114290
Chromosome 6Q24-Q25 Deletion Syndrome
Respiratory distress OMIM:612863
Multiple Acyl-Coa Dehydrogenase Deficiency
Respiratory distress OMIM:231680
Mogs-Cdg
Apnea, Hypoventilation, Respiratory distress ORPHA:79330
Scimitar Syndrome
Cough, Pulmonary arterial hypertension, Recurrent respiratory infections, Pneumothorax, Respirato... ORPHA:185
Alternating Hemiplegia Of Childhood
Apnea, Failure to thrive, Respiratory distress, Aspiration ORPHA:2131
Spondyloepiphyseal Dysplasia Congenita
Restrictive ventilatory defect, Respiratory distress OMIM:183900
Mandibulofacial Dysostosis, Guion-Almeida Type
Respiratory distress OMIM:610536
Prader-Willi Syndrome Due To Translocation
Recurrent respiratory infections, Obesity, Respiratory distress ORPHA:177907
Coccidioidomycosis
Pneumonia, Invasive fungal infection, Cough, Pleural empyema, Respiratory distress, Unusual CNS i... ORPHA:228123
Neuromuscular Oculoauditory Syndrome
Respiratory distress, Aspiration OMIM:618733
Mitochondrial Dna-Associated Leigh Syndrome
Dyspnea, Episodic respiratory distress, Failure to thrive, Hyperventilation, Apnea ORPHA:255210
Arterial Tortuosity Syndrome
Respiratory failure, Cardiorespiratory arrest, Respiratory distress, Dyspnea ORPHA:3342
Pfeiffer Syndrome Type 2
Tracheomalacia, Respiratory distress ORPHA:93259
Cocaine Intoxication
Tachypnea, Cough, Hyperventilation, Pneumothorax, Respiratory distress, Wheezing ORPHA:90068
Wac-Related Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome
Asthma, Nasal flaring, Recurrent infections, Obesity ORPHA:466943
Idiopathic Hypereosinophilic Syndrome
Asthma, Pulmonary embolism, Pleural effusion, Cough, Dyspnea, Failure to thrive, Respiratory dist... ORPHA:3260
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Pulmonary arterial hypertension, Failure to thrive, Pulmonary embolism, Respiratory distress ORPHA:79282
Pfeiffer Syndrome Type 3
Tracheomalacia, Respiratory distress ORPHA:93260
Meier-Gorlin Syndrome 1
Emphysema, Respiratory distress, Failure to thrive, Small for gestational age OMIM:224690
Cutis Gyrata-Acanthosis Nigricans-Craniosynostosis Syndrome
Respiratory distress ORPHA:1555
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Respiratory distress ORPHA:438216
Beare-Stevenson Cutis Gyrata Syndrome
Respiratory distress OMIM:123790
B3Galt6-Related Spondylodysplastic Ehlers-Danlos Syndrome
Restrictive ventilatory defect, Tracheomalacia, Atelectasis, Repeated pneumothoraces, Respiratory... ORPHA:536467
Ear-Patella-Short Stature Syndrome
Failure to thrive, Respiratory failure, Respiratory distress, Dyspnea ORPHA:2554
Thrombotic Thrombocytopenic Purpura, Hereditary
Respiratory distress OMIM:274150
Epidermolysis Bullosa, Junctional 7, With Interstitial Lung Disease And Nephrotic Syndrome
Neonatal respiratory distress, Recurrent respiratory infections, Respiratory distress, Respirator... OMIM:614748
Osteoglophonic Dysplasia
Failure to thrive, Respiratory distress OMIM:166250
Colchicine Poisoning
Cardiorespiratory arrest, Respiratory distress ORPHA:31824
Diamond-Blackfan Anemia 10
Respiratory distress OMIM:613309
Congenital Alveolar Capillary Dysplasia
Pulmonary arterial hypertension, Respiratory distress ORPHA:210122
Renal Dysplasia-Limb Defects Syndrome
Respiratory failure, Pneumothorax, Respiratory distress OMIM:266910
Congenital Tracheal Stenosis
Dyspnea, Upper airway obstruction, Neonatal asphyxia, Respiratory distress, Wheezing ORPHA:141127
Ethylene Glycol Poisoning
Episodic respiratory distress, Tachypnea, Abnormal pattern of respiration ORPHA:31826
Isolated Arrhinia
Respiratory distress ORPHA:1134
Schinzel-Giedion Syndrome
Respiratory distress, Recurrent pneumonia, Failure to thrive in infancy ORPHA:798
Microphthalmia With Linear Skin Defects Syndrome
Failure to thrive, Respiratory failure, Respiratory distress, Dyspnea ORPHA:2556
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked
Rhinitis, Respiratory distress OMIM:305100
Eisenmenger Syndrome
Hypoxemia, Increased pulmonary vascular resistance, Pulmonary arterial hypertension, Exertional d... ORPHA:97214
Arboleda-Tham Syndrome
Neonatal respiratory distress, Respiratory distress OMIM:616268
Kasabach-Merritt Syndrome
Respiratory distress, Hypopnea ORPHA:2330
Leptospirosis
Respiratory distress, Pleural effusion, Cough, Meningitis ORPHA:509
Congenital Total Pulmonary Venous Return Anomaly
Respiratory failure requiring assisted ventilation, Apneic episodes in infancy, Paroxysmal dyspne... ORPHA:99125
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Respiratory failure requiring assisted ventilation, Pneumonia, Cough, Rhinitis, Chronic lung dise... ORPHA:95455
Gitelman Syndrome
Failure to thrive, Respiratory distress ORPHA:358
Cleidocranial Dysplasia
Neonatal respiratory distress, Respiratory distress OMIM:119600
Plague
Respiratory distress, Acute infectious pneumonia, Sepsis, Meningitis ORPHA:707
Rubinstein-Taybi Syndrome 1
Recurrent upper respiratory tract infections, Truncal obesity, Failure to thrive, Obstructive sle... OMIM:180849
Aortic Arch Interruption
Exertional dyspnea, Tachypnea, Respiratory distress ORPHA:2299
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Failure to thrive, Respiratory distress ORPHA:83617
Stüve-Wiedemann Syndrome
Asthma, Apnea, Respiratory distress ORPHA:3206
Short-Rib Thoracic Dysplasia 15 With Polydactyly
Respiratory distress OMIM:617088
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome
Respiratory distress, Failure to thrive, Small for gestational age ORPHA:2255
Heterotaxy, Visceral, 1, X-Linked
Failure to thrive, Respiratory distress OMIM:306955
Tuberous Sclerosis Complex
Respiratory failure, Respiratory distress ORPHA:805
Metaphyseal Chondromatosis With D-2-Hydroxyglutaric Aciduria
Failure to thrive, Recurrent pneumonia, Sepsis, Respiratory distress ORPHA:99646
X-Linked Female Restricted Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability
Respiratory distress, Recurrent upper and lower respiratory tract infections ORPHA:480880
Doors Syndrome
Aspiration pneumonia, Respiratory distress ORPHA:79500
Ulbright-Hodes Syndrome
Respiratory failure, Pneumothorax, Respiratory distress ORPHA:3404
Generalized Arterial Calcification Of Infancy
Pulmonary arterial hypertension, Respiratory distress, Failure to thrive in infancy ORPHA:51608
Alström Syndrome
Recurrent pneumonia, Recurrent upper respiratory tract infections, Restrictive ventilatory defect... ORPHA:64
8Q24.3 Microdeletion Syndrome
Respiratory distress, Small for gestational age ORPHA:508488
Pmm2-Cdg
Aspiration pneumonia, Failure to thrive, Respiratory distress ORPHA:79318

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Muc4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Muc4.

No publications found that use IMPC mice or data for Muc4.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Muc4tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Muc4tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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