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Gene: Muc4 MGI:2153525

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
mucin 4
Synonyms:
4933405I11Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Muc4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Muc4 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Human Coronavirus Sensitivity
Susceptibility to coronavirus 229e OMIM:122460
Leishmaniasis, Tegumentary, Susceptibility To
Tegumentary leishmaniasis susceptibility OMIM:602068
Varicella, Severe Recurrent
Severe recurrent varicella OMIM:600670
Coxsackievirus B3 Susceptibility
Recurrent viral infections OMIM:120050
Ciliary Discoordination Due To Random Ciliary Orientation
Recurrent infections OMIM:215518
Immunodeficiency 30
Recurrent mycobacterial infections, Recurrent infections OMIM:614891
Pulmonary Blastoma
Weight loss, Dyspnea, Recurrent pneumonia, Cough ORPHA:64741
Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome
Respiratory distress, Recurrent infections ORPHA:171703
Immunodeficiency 95
Respiratory distress, Recurrent respiratory infections, Respiratory failure, Recurrent viral pneu... OMIM:619773
Interstitial Pneumonitis, Desquamative, Familial
Respiratory distress, Recurrent upper respiratory tract infections, Tachypnea, Respiratory failur... OMIM:263000
Isolated Congenital Hypoglossia/Aglossia
Respiratory distress, Dyspnea, Upper airway obstruction, Weight loss, Aspiration pneumonia ORPHA:141152
Emphysema, Congenital Lobar
Respiratory distress OMIM:130710
Neutrophil Actin Dysfunction
Recurrent bacterial infections OMIM:257150
Hypomyelination Neuropathy-Arthrogryposis Syndrome
Respiratory distress ORPHA:2680
Recurrent Respiratory Papillomatosis
Respiratory distress, Nonproductive cough, Wheezing, Recurrent upper respiratory tract infections... ORPHA:60032
Ciliary Dyskinesia, Primary, 47, And Lissencephaly
Respiratory distress, Recurrent respiratory infections, Bronchiectasis, Abnormal mucociliary clea... OMIM:619466
Pulmonary Non-Tuberculous Mycobacterial Infection
Respiratory distress, Crackles, Mycobacterium abscessus abscessus infection, Dyspnea, Chronic pul... ORPHA:411703
Bardet-Biedl Syndrome 16
Respiratory distress, Recurrent respiratory infections, Obesity, Recurrent otitis media, Bronchio... OMIM:615993
Bronchopulmonary Dysplasia
Respiratory distress, Central apnea, Respiratory failure requiring assisted ventilation, Small fo... ORPHA:70589
Idiopathic Bronchiectasis
Crackles, Productive cough, Cachexia, Dyspnea, Wheezing, Emphysema, Bronchiectasis, Recurrent Hae... ORPHA:60033
Familial Nasal Acilia
Respiratory distress, Dyspnea, Recurrent upper respiratory tract infections, Bronchiectasis, Chro... ORPHA:922
Gaucher Disease Type 2
Respiratory distress, Recurrent respiratory infections, Abnormal pattern of respiration, Cough ORPHA:77260
Chronic Pneumonitis Of Infancy
Respiratory distress, Intercostal retractions, Reduced forced vital capacity, Tachypnea, Hypoxemi... ORPHA:91359
Growth Hormone Insensitivity Syndrome With Immune Dysregulation 1, Autosomal Recessive
Respiratory distress, Failure to thrive, Lymphocytic interstitial pneumonia OMIM:245590
Hereditary Pulmonary Alveolar Proteinosis
Respiratory distress, Respiratory failure requiring assisted ventilation, Failure to thrive in in... ORPHA:264675
Pleural Mesothelioma
Respiratory distress, Dyspnea, Abnormal respiratory system physiology, Weight loss, Cough, Pleura... ORPHA:50251
Laryngotracheal Angioma
Respiratory distress, Intercostal retractions, Apnea, Wheezing, Stridor, Cough ORPHA:137935
Succinic Acidemia
Respiratory distress OMIM:600335
Muscular Hypertonia, Lethal
Respiratory distress, Pneumonia OMIM:254120
Cryptogenic Organizing Pneumonia
Respiratory distress, Bronchial breath sound, Crackles, Nonproductive cough, Dyspnea, Wheezing, P... ORPHA:1302
Myopathy, Congenital, With Fiber-Type Disproportion, X-Linked
Respiratory distress, Respiratory insufficiency due to muscle weakness, Decreased body weight OMIM:300580
Severe Acute Respiratory Syndrome
Respiratory distress, Respiratory failure requiring assisted ventilation, Dyspnea, Hypoxemia, Acu... ORPHA:140896
Congenital Lobar Emphysema
Respiratory distress, Emphysema ORPHA:1928
Respiratory Distress Syndrome In Premature Infants
Respiratory distress, Dyspnea, Neonatal respiratory distress, Tachypnea OMIM:267450
Myasthenic Syndrome, Congenital, 6, Presynaptic
Respiratory distress, Respiratory insufficiency due to muscle weakness, Sudden episodic apnea, Ap... OMIM:254210
Laryngomalacia
Respiratory distress, Congenital laryngeal stridor OMIM:150280
Mitochondrial Dna Depletion Syndrome, Myopathic Form
Respiratory distress, Failure to thrive in infancy, Respiratory insufficiency due to muscle weakn... ORPHA:254875
Surfactant Metabolism Dysfunction, Pulmonary, 2
Respiratory distress, Nonspecific interstitial pneumonia, Spontaneous pneumothorax, Reduced force... OMIM:610913
Congenital Myopathy 10A, Severe Variant
Respiratory distress, Respiratory insufficiency, Restrictive ventilatory defect, Respiratory fail... OMIM:614399
Ciliary Dyskinesia, Primary, 2
Respiratory distress, Recurrent respiratory infections, Sinusitis, Bronchiectasis, Immotile cilia... OMIM:606763
Myasthenic Syndrome, Congenital, 4A, Slow-Channel
Respiratory distress, Respiratory insufficiency due to muscle weakness, Sudden episodic apnea, Ap... OMIM:605809
Nipah Virus Disease
Respiratory distress, Recurrent pharyngitis, Infectious encephalitis, Cough ORPHA:99825
Cardiomyopathy-Hypotonia-Lactic Acidosis Syndrome
Respiratory distress, Failure to thrive ORPHA:91130
Bronchiolitis Obliterans With Obstructive Pulmonary Disease
Pneumonia, Reduced forced expiratory volume in one second, Reduced forced vital capacity, Dyspnea... ORPHA:1303
Pneumocystosis
Respiratory failure requiring assisted ventilation, Pneumocystis jirovecii pneumonia, Nonproducti... ORPHA:723
Intellectual Developmental Disorder With Speech Delay And Axonal Peripheral Neuropathy
Respiratory distress OMIM:619099
Staphylococcal Necrotizing Pneumonia
Respiratory distress, Pneumonia, Nonproductive cough, Severe infection, Tachypnea, Dyspnea, Sepsi... ORPHA:36238
Severe X-Linked Mitochondrial Encephalomyopathy
Respiratory distress, Respiratory insufficiency ORPHA:238329
Developmental And Epileptic Encephalopathy 30
Respiratory distress OMIM:616341
Lethal Osteosclerotic Bone Dysplasia
Respiratory distress, Dyspnea, Respiratory failure ORPHA:1832
Acute Lung Injury
Respiratory distress, Pneumonia, Dyspnea, Tachypnea, Sepsis, Hypoxemia, Respiratory failure ORPHA:178320
Cardiomyopathy, Dilated, 1Gg
Respiratory distress OMIM:613642
X-Linked Centronuclear Myopathy
Respiratory distress, Recurrent respiratory infections, Respiratory failure requiring assisted ve... ORPHA:596
Mitochondrial Dna Depletion Syndrome 8A (Encephalomyopathic Type With Renal Tubulopathy)
Respiratory distress, Failure to thrive, Cachexia, Weight loss OMIM:612075
N-Acetylglutamate Synthase Deficiency
Respiratory distress, Failure to thrive OMIM:237310
Perching Syndrome
Respiratory distress OMIM:617055
Congenital Disorder Of Glycosylation, Type Iy
Respiratory distress, Failure to thrive OMIM:300934
Choanal Atresia
Respiratory distress, Recurrent respiratory infections, Upper airway obstruction, Tracheomalacia,... ORPHA:137914
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 6
Recurrent acute respiratory tract infection, Paradoxical respiration, Respiratory distress OMIM:620011
Short Chain Acyl-Coa Dehydrogenase Deficiency
Respiratory distress, Failure to thrive ORPHA:26792
Laryngotracheoesophageal Cleft
Recurrent respiratory infections, Neonatal respiratory distress, Dyspnea, Stridor, Cough, Aspiration ORPHA:2004
Congenital Laryngeal Web
Respiratory distress, Stridor ORPHA:2374
Pulmonary Alveolar Proteinosis, Acquired
Recurrent respiratory infections, Brain abscess, Pneumonia, Dyspnea, Inspiratory crackles, Hypoxe... OMIM:610910
Respiratory Bronchiolitis-Interstitial Lung Disease Syndrome
Nonproductive cough, Dyspnea, Chronic pulmonary obstruction, Wheezing, Bronchiectasis, Inspirator... ORPHA:79127
Infant Acute Respiratory Distress Syndrome
Pneumonia, Nasal flaring, Tachypnea, Sepsis, Hypoxemia, Respiratory failure ORPHA:70587
Inhalational Anthrax
Respiratory distress, Dyspnea, Sepsis ORPHA:247257
Anaplastic Thyroid Carcinoma
Respiratory distress, Dyspnea, Upper airway obstruction, Weight loss, Stridor, Cough ORPHA:142
Avian Influenza
Respiratory distress, Pneumonia, Productive cough, Nonproductive cough, Dyspnea, Tachypnea, Pneum... ORPHA:454836
Combined Oxidative Phosphorylation Deficiency 30
Respiratory distress, Failure to thrive OMIM:616974
Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
Respiratory distress, Recurrent respiratory infections, Neonatal respiratory distress, Crackles, ... OMIM:610978
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Respiratory distress, Failure to thrive, Respiratory insufficiency due to muscle weakness OMIM:613561
Idiopathic Neonatal Atrial Flutter
Respiratory distress, Tachypnea, Large for gestational age ORPHA:45452
Chitayat Syndrome
Respiratory distress, Recurrent respiratory infections, Tracheomalacia OMIM:617180
Imperforate Oropharynx-Costovertebral Anomalies Syndrome
Respiratory distress, Recurrent respiratory infections, Respiratory failure, Dyspnea ORPHA:2759
Nasolacrimal Duct Cyst
Intercostal retractions, Episodic respiratory distress, Recurrent infections, Stridor, Paroxysmal... ORPHA:141083
Neurodevelopmental Disorder With Spastic Quadriplegia And Brain Abnormalities With Or Without Seizures
Respiratory distress OMIM:617977
Mitochondrial Myopathy With Reversible Cytochrome C Oxidase Deficiency
Respiratory distress, Respiratory failure requiring assisted ventilation, Ventilator dependence w... ORPHA:254864
Surfactant Metabolism Dysfunction, Pulmonary, 3
Respiratory distress, Neonatal respiratory distress, Nonspecific interstitial pneumonia, Apnea, F... OMIM:610921
Malaria
Respiratory distress ORPHA:673
Congenital Pulmonary Lymphangiectasia
Respiratory distress, Chronic pulmonary obstruction, Cough, Pulmonary arterial hypertension, Pleu... ORPHA:2414
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut0
Respiratory distress, Sepsis ORPHA:289916
Thyroid Lymphoma
Respiratory distress, Dyspnea, Stridor, Upper airway obstruction ORPHA:97285
Meconium Aspiration Syndrome
Respiratory distress, Neonatal asphyxia, Wheezing, Pneumothorax, Hypoxemia, Aspiration pneumonia,... ORPHA:70588
Stt3B-Cdg
Respiratory distress, Failure to thrive ORPHA:370924
Developmental And Epileptic Encephalopathy 68
Respiratory distress, Failure to thrive OMIM:618201
Stuve-Wiedemann Syndrome 2
Respiratory distress, Pulmonary arterial hypertension OMIM:619751
Coenzyme Q10 Deficiency, Primary, 8
Respiratory distress, Small for gestational age OMIM:616733
Tularemia
Respiratory distress, Brain abscess, Pneumonia, Cough, Pleural effusion, Meningitis ORPHA:3392
Congenital Disorder Of Glycosylation, Type Ix
Respiratory distress, Failure to thrive OMIM:615597
Brown-Vialetto-Van Laere Syndrome 1
Respiratory distress, Recurrent respiratory infections, Respiratory failure requiring assisted ve... OMIM:211530
Mitochondrial Pyruvate Carrier Deficiency
Respiratory distress OMIM:614741
Paternal 20Q13.2Q13.3 Microdeletion Syndrome
Respiratory distress, Failure to thrive ORPHA:261304
Auriculocondylar Syndrome 2A
Respiratory distress, Apnea OMIM:614669
Progressive Supranuclear Palsy-Parkinsonism Syndrome
Respiratory distress ORPHA:240085
Lethal Recessive Chondrodysplasia
Respiratory distress ORPHA:1423
Congenital Diaphragmatic Hernia
Respiratory distress, Hypoxemia ORPHA:2140
Rnf13-Related Severe Early-Onset Epileptic Encephalopathy
Respiratory distress, Failure to thrive, Sepsis ORPHA:544503
Myopathy And Diabetes Mellitus
Respiratory distress ORPHA:2596
Congenital Tracheomalacia
Neonatal respiratory distress, Apnea, Intercostal retractions, Pneumonia, Productive cough, Dyspn... ORPHA:95430
Pomt1-Related Limb-Girdle Muscular Dystrophy R11
Respiratory distress, Dyspnea, Cough ORPHA:86812
Congenital Disorder Of Glycosylation, Type Iu
Respiratory distress, Neonatal respiratory distress OMIM:615042
Holocarboxylase Synthetase Deficiency
Respiratory distress, Tachypnea, Weight loss ORPHA:79242
Diaphanospondylodysostosis
Respiratory distress ORPHA:66637
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut-
Respiratory distress, Failure to thrive ORPHA:79312
Neurogenic Arthrogryposis Multiplex Congenita
Respiratory distress, Respiratory insufficiency due to muscle weakness ORPHA:1143
Congenital Muscular Dystrophy With Intellectual Disability And Severe Epilepsy
Respiratory distress, Recurrent respiratory infections, Failure to thrive ORPHA:329178
Folinic Acid-Responsive Seizures
Respiratory distress, Apnea ORPHA:79097
Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To 5Q31.3 Microdeletion
Respiratory distress, Hypoventilation, Apnea, Recurrent pneumonia, Aspiration pneumonia ORPHA:314655
Slc35A1-Cdg
Respiratory distress, Pneumonia, Hypoxemia ORPHA:238459
Progressive Supranuclear Palsy-Corticobasal Syndrome
Respiratory distress ORPHA:240103
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema
Respiratory distress, Upper airway obstruction ORPHA:100057
Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia
Respiratory distress, Respiratory failure, Tachypnea, Respiratory insufficiency OMIM:614299
Congenital Disorder Of Glycosylation, Type Ie
Respiratory distress, Failure to thrive OMIM:608799
Hypoglossia With Situs Inversus
Respiratory distress, Upper airway obstruction OMIM:612776
Encephalopathy, Acute, Infection-Induced, Susceptibility To, 9
Respiratory distress, Neonatal respiratory distress, Apnea, Hypopnea, Recurrent lower respiratory... OMIM:618426
Shwachman-Diamond Syndrome 1
Respiratory distress, Neonatal respiratory distress, Small for gestational age, Recurrent infecti... OMIM:260400
Sepsis In Premature Infants
Neonatal sepsis, Disseminated viral infection, Abnormal mucociliary clearance, Small for gestatio... ORPHA:90051
Nocardiosis
Respiratory distress, Brain abscess, Pneumonia, Productive cough, Meningitis, Severe infection, N... ORPHA:31204
Combined Oxidative Phosphorylation Deficiency 19
Respiratory distress, Stridor, Failure to thrive OMIM:615595
Primary Dystonia, Dyt4 Type
Respiratory distress, Eunuchoid habitus ORPHA:98805
Biotinidase Deficiency
Respiratory distress, Apnea, Recurrent viral infections, Recurrent candida infections, Recurrent ... ORPHA:79241
Infantile Krabbe Disease
Respiratory distress, Cachexia, Recurrent infections, Respiratory failure, Failure to thrive ORPHA:206436
Acquired Methemoglobinemia
Respiratory distress, Dyspnea, Hypoxemia ORPHA:464453
Synaptic Congenital Myasthenic Syndromes
Respiratory distress, Hypoventilation, Neonatal respiratory distress, Respiratory insufficiency, ... ORPHA:98915
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
Respiratory distress, Failure to thrive ORPHA:927
Congenital Disorder Of Glycosylation, Type Ig
Respiratory distress, Small for gestational age, Recurrent upper respiratory tract infections, Re... OMIM:607143
Odontochondrodysplasia 1
Respiratory distress, Recurrent respiratory infections OMIM:184260
Carnitine Deficiency, Systemic Primary
Respiratory distress, Failure to thrive OMIM:212140
Tetrasomy 5P
Respiratory distress, Recurrent respiratory infections, Failure to thrive, Pulmonary arterial hyp... ORPHA:3309
Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans
Respiratory distress, Brain abscess, Central apnea, Respiratory failure, Recurrent otitis media, ... OMIM:616482
Oromandibular Dystonia
Respiratory distress, Weight loss ORPHA:93958
Mitochondrial Complex I Deficiency, Nuclear Type 37
Respiratory distress, Pulmonary arterial hypertension, Failure to thrive OMIM:619272
Infantile-Onset X-Linked Spinal Muscular Atrophy
Respiratory distress, Respiratory insufficiency ORPHA:1145
Bacterial Toxic-Shock Syndrome
Respiratory distress, Recurrent urinary tract infections, Sinusitis, Pneumonia, Severe varicella ... ORPHA:36234
Oculocerebrofacial Syndrome, Kaufman Type
Respiratory distress, Dyspnea, Respiratory failure, Failure to thrive ORPHA:2707
Congenital Enterovirus Infection
Respiratory distress, Meningitis, Sepsis, Pleural effusion, Infectious encephalitis ORPHA:292
Neurodevelopmental Disorder With Hypotonia, Facial Dysmorphism, And Brain Abnormalities
Respiratory distress, Recurrent respiratory infections OMIM:619383
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Respiratory distress, Small for gestational age, Pneumonia, Episodic tachypnea, Overweight, Tachy... ORPHA:26793
Complete Atrioventricular Septal Defect
Intercostal retractions, Crackles, Wheezing, Recurrent pneumonia, Tachypnea, Elevated pulmonary a... ORPHA:1329
Brain-Lung-Thyroid Syndrome
Respiratory distress, Recurrent respiratory infections, Neonatal respiratory distress, Asthma, Re... ORPHA:209905
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Respiratory distress, Large for gestational age ORPHA:226313
Kniest Dysplasia
Recurrent otitis media, Respiratory distress, Tracheomalacia OMIM:156550
Lissencephaly Syndrome, Norman-Roberts Type
Respiratory distress ORPHA:89844
Mercury Poisoning
Respiratory distress, Dyspnea, Respiratory failure, Interstitial pneumonitis ORPHA:330021
Fructose-1,6-Bisphosphatase Deficiency
Respiratory distress, Intermittent hyperventilation, Episodic tachypnea, Dyspnea, Apneic episodes... ORPHA:348
Mitochondrial Complex Iv Deficiency, Nuclear Type 2
Respiratory distress, Inspiratory stridor, Irregular respiration OMIM:604377
Pulmonary Hypertension, Primary, 3
Increased pulmonary vascular resistance, Dyspnea, Elevated pulmonary artery pressure, Pulmonary a... OMIM:615343
Mitochondrial Complex Iv Deficiency, Nuclear Type 1
Respiratory distress, Respiratory insufficiency due to muscle weakness, Respiratory failure, Fail... OMIM:220110
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Respiratory distress, Failure to thrive, Respiratory insufficiency ORPHA:367
Odontochondrodysplasia
Respiratory distress ORPHA:166272
Muscular Dystrophy, Congenital, With Or Without Seizures
Respiratory distress, Respiratory failure OMIM:620166
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Respiratory distress, Recurrent respiratory infections, Failure to thrive in infancy, Pneumonia, ... ORPHA:37042
Glycogen Storage Disease Due To Acid Maltase Deficiency, Infantile Onset
Respiratory distress, Respiratory failure requiring assisted ventilation, Respiratory insufficien... ORPHA:308552
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency
Respiratory distress, Failure to thrive OMIM:251000
Microlissencephaly-Micromelia Syndrome
Respiratory distress, Failure to thrive ORPHA:50810
Mucopolysaccharidosis-Plus Syndrome
Respiratory distress, Recurrent respiratory infections, Recurrent bronchopulmonary infections, Re... OMIM:617303
Congenital Myasthenic Syndrome
Recurrent respiratory infections, Sudden episodic apnea, Intermittent episodes of respiratory ins... ORPHA:590
Presynaptic Congenital Myasthenic Syndromes
Recurrent respiratory infections, Sudden episodic apnea, Intermittent episodes of respiratory ins... ORPHA:98914
Toxic Epidermal Necrolysis
Respiratory distress, Recurrent respiratory infections, Sepsis, Weight loss, Restrictive ventilat... ORPHA:537
Episodic Ataxia Type 1
Respiratory distress ORPHA:37612
3-Methylglutaconic Aciduria, Type Viib
Respiratory distress, Recurrent pneumonia, Recurrent infections OMIM:616271
Esophageal Atresia
Respiratory distress, Recurrent respiratory infections, Small for gestational age, Failure to thr... ORPHA:1199
Q Fever
Respiratory distress, Unusual infection, Pneumonia, Weight loss, Cough, Pleural effusion, Meningi... ORPHA:781
Short-Rib Thoracic Dysplasia 16 With Or Without Polydactyly
Respiratory distress OMIM:617102
Isolated Atp Synthase Deficiency
Respiratory distress ORPHA:254913
Farber Disease
Respiratory distress, Failure to thrive, Recurrent upper respiratory tract infections, Respirator... ORPHA:333
Short-Rib Thoracic Dysplasia 19 With Or Without Polydactyly
Respiratory distress, Respiratory failure OMIM:617895
Cryptococcosis
Respiratory distress, Pneumonia, Dyspnea, Sepsis, Cough, Pleural effusion, Meningitis ORPHA:1546
Tetanus
Respiratory distress, Tachypnea ORPHA:3299
Restrictive Dermopathy 2
Respiratory distress OMIM:619793
Triosephosphate Isomerase Deficiency
Respiratory distress, Respiratory insufficiency due to muscle weakness, Respiratory insufficiency... OMIM:615512
Myotonic Dystrophy 1
Respiratory distress OMIM:160900
Moebius Syndrome
Respiratory distress OMIM:157900
Agnathia-Otocephaly Complex
Respiratory distress, Tracheomalacia OMIM:202650
Pachyonychia Congenita
Respiratory distress, Failure to thrive ORPHA:2309
Craniofaciofrontodigital Syndrome
Respiratory distress, Dyspnea, Pulmonary arterial hypertension, Large for gestational age ORPHA:363705
Radio-Renal Syndrome
Respiratory distress, Dyspnea, Respiratory failure, Chylothorax, Pleural effusion ORPHA:3015
Oculopharyngodistal Myopathy 1
Respiratory distress, Hypercapnia, Reduced forced vital capacity, Respiratory insufficiency due t... OMIM:164310
Achondroplasia
Recurrent otitis media, Upper airway obstruction, Respiratory distress OMIM:100800
Methylmalonic Aciduria, Cblb Type
Respiratory distress, Failure to thrive OMIM:251110
Chronic Recurrent Multifocal Osteomyelitis 2, With Periostitis And Pustulosis
Respiratory distress, Failure to thrive in infancy OMIM:612852
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Respiratory distress, Recurrent respiratory infections, Sepsis, Stridor, Recurrent gastroenteriti... ORPHA:505248
Spinal muscular atrophy, type I, with congenital bone fractures
Respiratory distress OMIM:271225
Myotubular Myopathy With Abnormal Genital Development
Respiratory distress OMIM:300219
Mgat2-Cdg
Respiratory distress, Recurrent upper and lower respiratory tract infections, Failure to thrive ORPHA:79329
Osteogenesis Imperfecta, Type X
Respiratory distress, Recurrent pneumonia, Chronic lung disease OMIM:613848
Diaphanospondylodysostosis
Respiratory distress, Tracheomalacia, Respiratory insufficiency OMIM:608022
Japanese Encephalitis
Respiratory distress, Abnormal pattern of respiration, Respiratory paralysis, Meningitis, Infecti... ORPHA:79139
Gaucher Disease, Perinatal Lethal
Respiratory distress, Apnea, Decreased body weight OMIM:608013
Lujo Hemorrhagic Fever
Respiratory distress, Crackles, Nonproductive cough, Severe viral infection, Rhinitis ORPHA:319213
Severe Generalized Junctional Epidermolysis Bullosa
Respiratory distress, Recurrent urinary tract infections, Pneumonia, Dyspnea, Pneumothorax, Sepsi... ORPHA:79404
Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis
Respiratory distress OMIM:606164
Hemorrhagic Fever-Renal Syndrome
Respiratory distress, Pneumonia, Epistaxis, Dyspnea, Severe infection, Respiratory failure, Cough... ORPHA:340
Intellectual Developmental Disorder, X-Linked 99, Syndromic, Female-Restricted
Respiratory distress, Recurrent respiratory infections OMIM:300968
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Respiratory distress, Recurrent respiratory infections, Failure to thrive, Apnea ORPHA:17
Methylmalonic Aciduria, Cbla Type
Respiratory distress, Failure to thrive OMIM:251100
Microcephaly-Seizures-Intellectual Disability-Heart Disease Syndrome
Respiratory distress, Pulmonary arterial hypertension ORPHA:2519
Lymphatic Malformation 7
Respiratory distress, Pleural effusion, Chylothorax OMIM:617300
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Respiratory distress ORPHA:990
Rodrigues Blindness
Nasal flaring OMIM:268320
Listeriosis
Respiratory distress, Brain abscess, Unusual skin infection, Pneumonia, Meningitis, Unusual CNS i... ORPHA:533
Corpus Callosum, Agenesis Of, With Facial Anomalies And Robin Sequence
Respiratory distress, Neonatal respiratory distress, Tracheomalacia OMIM:217980
Adnp Syndrome
Respiratory distress, Recurrent urinary tract infections, Recurrent upper respiratory tract infec... ORPHA:404448
Scimitar Syndrome
Respiratory distress, Recurrent respiratory infections, Pneumothorax, Cough, Pulmonary arterial h... ORPHA:185
Ramos-Arroyo Syndrome
Respiratory distress, Severe failure to thrive, Decreased body weight ORPHA:1051
Mogs-Cdg
Respiratory distress, Hypoventilation, Apnea ORPHA:79330
Hereditary Angioedema Type 1
Respiratory distress, Dyspnea, Inspiratory stridor ORPHA:100050
Prader-Willi Syndrome Due To Translocation
Respiratory distress, Recurrent respiratory infections, Obesity ORPHA:177907
Glycogen Storage Disease Due To Acid Maltase Deficiency
Respiratory distress, Orthopnea, Respiratory insufficiency due to muscle weakness, Respiratory in... ORPHA:365
Cardiomyopathy, Familial Hypertrophic, 4
Respiratory distress, Dyspnea OMIM:115197
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type
Respiratory distress OMIM:151210
Chromosome 6Q24-Q25 Deletion Syndrome
Respiratory distress OMIM:612863
Neurodegeneration And Seizures Due To Copper Transport Defect
Respiratory distress, Pneumothorax OMIM:620306
Alternating Hemiplegia Of Childhood
Respiratory distress, Aspiration, Failure to thrive, Apnea ORPHA:2131
Campomelic Dysplasia
Respiratory distress, Neonatal respiratory distress, Apnea, Recurrent upper respiratory tract inf... OMIM:114290
Multiple Acyl-Coa Dehydrogenase Deficiency
Respiratory distress OMIM:231680
Neuromuscular Oculoauditory Syndrome
Respiratory distress, Aspiration OMIM:618733
Mandibulofacial Dysostosis, Guion-Almeida Type
Respiratory distress OMIM:610536
Spondyloepiphyseal Dysplasia Congenita
Respiratory distress, Restrictive ventilatory defect OMIM:183900
Congenital Disorder Of Deglycosylation 1
Respiratory distress, Recurrent respiratory infections, Decreased body weight OMIM:615273
Coccidioidomycosis
Respiratory distress, Coccidioidal meningitis, Pneumonia, Invasive fungal infection, Unusual CNS ... ORPHA:228123
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Respiratory distress ORPHA:438216
Arterial Tortuosity Syndrome
Respiratory distress, Dyspnea, Respiratory failure, Cardiorespiratory arrest ORPHA:3342
Pfeiffer Syndrome Type 2
Respiratory distress, Tracheomalacia ORPHA:93259
Wac-Related Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome
Asthma, Obesity, Nasal flaring, Recurrent infections ORPHA:466943
Congenital Myopathy 2C, Severe Infantile, Autosomal Dominant
Respiratory distress, Respiratory failure, Chylothorax OMIM:620278
Cutis Gyrata-Acanthosis Nigricans-Craniosynostosis Syndrome
Respiratory distress ORPHA:1555
Mitochondrial Dna-Associated Leigh Syndrome
Apnea, Dyspnea, Episodic respiratory distress, Failure to thrive, Hyperventilation ORPHA:255210
Pfeiffer Syndrome Type 3
Respiratory distress, Tracheomalacia ORPHA:93260
Idiopathic Hypereosinophilic Syndrome
Respiratory distress, Pulmonary embolism, Dyspnea, Asthma, Cough, Pleural effusion, Failure to th... ORPHA:3260
Cocaine Intoxication
Respiratory distress, Wheezing, Tachypnea, Pneumothorax, Cough, Hyperventilation ORPHA:90068
Auriculocondylar Syndrome
Respiratory distress ORPHA:137888
B3Galt6-Related Spondylodysplastic Ehlers-Danlos Syndrome
Respiratory distress, Repeated pneumothoraces, Respiratory insufficiency, Restrictive ventilatory... ORPHA:536467
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Respiratory distress, Pulmonary arterial hypertension, Failure to thrive, Pulmonary embolism ORPHA:79282
Meier-Gorlin Syndrome 1
Respiratory distress, Emphysema, Failure to thrive, Small for gestational age OMIM:224690
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Respiratory distress, Failure to thrive OMIM:617156
Ear-Patella-Short Stature Syndrome
Respiratory distress, Dyspnea, Respiratory failure, Failure to thrive ORPHA:2554
Thrombotic Thrombocytopenic Purpura, Hereditary
Respiratory distress OMIM:274150
Congenital Myopathy 22B, Severe Fetal
Respiratory distress, Pleural effusion OMIM:620369
Arboleda-Tham Syndrome
Respiratory distress, Recurrent respiratory infections, Recurrent urinary tract infections, Neona... OMIM:616268
Epidermolysis Bullosa, Junctional 7, With Interstitial Lung Disease And Nephrotic Syndrome
Respiratory distress, Recurrent respiratory infections, Neonatal respiratory distress, Respirator... OMIM:614748
Colchicine Poisoning
Respiratory distress, Cardiorespiratory arrest ORPHA:31824
Beare-Stevenson Cutis Gyrata Syndrome
Respiratory distress OMIM:123790
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Respiratory distress, Failure to thrive OMIM:256810
Congenital Alveolar Capillary Dysplasia
Respiratory distress, Pulmonary arterial hypertension ORPHA:210122
Diamond-Blackfan Anemia 10
Respiratory distress OMIM:613309
Hyperparathyroidism, Transient Neonatal
Respiratory distress OMIM:618188
Congenital Tracheal Stenosis
Respiratory distress, Neonatal asphyxia, Wheezing, Dyspnea, Upper airway obstruction ORPHA:141127
Glycogen Storage Disease Of Heart, Lethal Congenital
Respiratory distress, Pleural effusion, Apnea OMIM:261740
Ethylene Glycol Poisoning
Tachypnea, Episodic respiratory distress, Abnormal pattern of respiration ORPHA:31826
Osteoglophonic Dysplasia
Respiratory distress, Failure to thrive OMIM:166250
Rubinstein-Taybi Syndrome 1
Respiratory distress, Small for gestational age, Recurrent upper respiratory tract infections, Tr... OMIM:180849
Kasabach-Merritt Syndrome
Respiratory distress, Hypopnea ORPHA:2330
Schinzel-Giedion Syndrome
Respiratory distress, Recurrent pneumonia, Failure to thrive in infancy ORPHA:798
Isolated Arrhinia
Respiratory distress ORPHA:1134
Microphthalmia With Linear Skin Defects Syndrome
Respiratory distress, Dyspnea, Respiratory failure, Failure to thrive ORPHA:2556
Eisenmenger Syndrome
Respiratory distress, Brain abscess, Increased pulmonary vascular resistance, Wheezing, Hypoxemia... ORPHA:97214
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Respiratory distress, Respiratory failure requiring assisted ventilation, Pneumonia, Sepsis, Rhin... ORPHA:95455
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked
Respiratory distress, Rhinitis OMIM:305100
Congenital Total Pulmonary Venous Return Anomaly
Respiratory distress, Recurrent respiratory infections, Respiratory failure requiring assisted ve... ORPHA:99125
Leptospirosis
Respiratory distress, Pleural effusion, Meningitis, Cough ORPHA:509
Aortic Arch Interruption
Respiratory distress, Tachypnea, Exertional dyspnea ORPHA:2299
Cleidocranial Dysplasia 1
Respiratory distress, Neonatal respiratory distress OMIM:119600
Heterotaxy, Visceral, 1, X-Linked
Respiratory distress, Failure to thrive OMIM:306955
Gitelman Syndrome
Respiratory distress, Failure to thrive ORPHA:358
Plague
Respiratory distress, Acute infectious pneumonia, Meningitis, Sepsis ORPHA:707
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome
Respiratory distress, Failure to thrive, Small for gestational age ORPHA:2255
Stüve-Wiedemann Syndrome
Respiratory distress, Asthma, Apnea ORPHA:3206
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Respiratory distress, Failure to thrive ORPHA:83617
8Q24.3 Microdeletion Syndrome
Respiratory distress, Small for gestational age ORPHA:508488
Tuberous Sclerosis Complex
Respiratory distress, Respiratory failure ORPHA:805
Metaphyseal Chondromatosis With D-2-Hydroxyglutaric Aciduria
Respiratory distress, Failure to thrive, Recurrent pneumonia, Sepsis ORPHA:99646
X-Linked Female Restricted Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability
Respiratory distress, Recurrent upper and lower respiratory tract infections ORPHA:480880
Doors Syndrome
Respiratory distress, Aspiration pneumonia ORPHA:79500
Short-Rib Thoracic Dysplasia 15 With Polydactyly
Respiratory distress OMIM:617088
Ulbright-Hodes Syndrome
Respiratory distress, Respiratory failure, Pneumothorax ORPHA:3404
Generalized Arterial Calcification Of Infancy
Respiratory distress, Pulmonary arterial hypertension, Failure to thrive in infancy ORPHA:51608
Alström Syndrome
Respiratory distress, Recurrent cystitis, Recurrent urinary tract infections, Recurrent upper res... ORPHA:64
Pmm2-Cdg
Respiratory distress, Failure to thrive, Aspiration pneumonia ORPHA:79318

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Muc4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Muc4.

No publications found that use IMPC mice or data for Muc4.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Muc4tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Muc4tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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