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Gene: Hnmt MGI:2153181

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
histamine N-methyltransferase
Synonyms:
1500031F01Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Hnmt mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Hnmt by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Asthma, Susceptibility To
OMIM:600807
Intellectual Developmental Disorder, Autosomal Recessive 51
OMIM:616739

The table below shows human diseases predicted to be associated to Hnmt by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy, Ataxia, Depression OMIM:604121
Narcolepsy 3
Narcolepsy OMIM:609039
Narcolepsy 1
Narcolepsy OMIM:161400
Narcolepsy 7
Narcolepsy OMIM:614250
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy, Ataxia, Depression ORPHA:314404
Niemann-Pick Disease Type C
Ataxia, Narcolepsy, Depression, Progressive gait ataxia, Gait disturbance, Low frustration tolera... ORPHA:646
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Narcolepsy, Emotional lability, Impaired social interactions, Depression ORPHA:293987
African Trypanosomiasis
Akinesia, Narcolepsy, Choreoathetosis, Irritability, Gait disturbance, Difficulty walking ORPHA:3385
Asthma, Susceptibility To
OMIM:600807
Intellectual Developmental Disorder, Autosomal Recessive 51
OMIM:616739

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Hnmt

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hnmt.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Contribution of astrocytic histamine N-methyltransferase to histamine clearance and brain function in mice. Neuropharmacology (April 2022) Hnmttm1a(KOMP)Wtsi 35487272
Histamine N-methyltransferase regulates aggression and the sleep-wake cycle. Scientific reports (November 2017) Hnmttm1a(KOMP)Wtsi PMC5698467

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Hnmttm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Hnmttm298272(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Hnmttm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Hnmttm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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