Gene Summary

adenosine deaminase, RNA-specific, B2
RED2,  Adar3

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
small testis Adarb2em1(IMPC)Tcp HOM Early adult 0.00
limb grasping Adarb2em1(IMPC)Tcp HOM Early adult 2.60×10-06
abnormal coat/ hair morphology Adarb2em1(IMPC)Tcp HOM Early adult 1.41×10-07
decreased bone mineral density Adarb2em1(IMPC)Tcp HOM   Early adult 6.79×10-05
small kidney Adarb2em1(IMPC)Tcp HOM Early adult 0.00
abnormal spleen morphology Adarb2em1(IMPC)Tcp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


Panel B FCS file(s)

6 Images


XRay Images Skull Dorso Ventral Orientation

10 Images

Eye Morphology

Images Ophthalmoscopy

4 Images


XRay Images Whole Body Lateral Orientation

10 Images


XRay Images Skull Lateral Orientation

10 Images

Gross Pathology and Tissue Collection


8 Images


XRay Images Whole Body Dorso Ventral

10 Images



1 Images


Panel A FCS file(s)

6 Images

Human diseases caused by Adarb2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Adarb2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Anorexia, Irritability, Obsessive-compulsive trait, Abnormal fear-induced behavior, Depression, E... ORPHA:66624
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Pseudobulbar paralysis, Abnormal fear-induced behavior, Delirium, Aggressive behavior ORPHA:208441
Hypogonadism, Male
Testicular atrophy, Male hypogonadism, Micropenis, Hypospadias OMIM:241100
Isolated Follicle Stimulating Hormone Deficiency
Delayed puberty, Male hypogonadism, Azoospermia, Oligozoospermia, Delayed menarche, Testicular at... ORPHA:52901
Isolated Splenogonadal Fusion
Abnormal epididymis morphology, Ectopia of the spleen, Bilateral cryptorchidism, Unilateral crypt... ORPHA:457083
Spermatogenic Failure, X-Linked, 2
Male infertility, Spermatogenesis maturation arrest, Testicular atrophy, Azoospermia OMIM:309120
Hemochromatosis, Type 1
Cirrhosis, Hepatomegaly, Azoospermia, Hepatocellular carcinoma, Impotence, Osteoporosis, Testicul... OMIM:235200
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Unilateral renal agenesis, Azoospermia, Decreased circulating follicle stimulating hormone concen... OMIM:308700
Kallmann Syndrome With Spastic Paraplegia
Unilateral renal agenesis, Decreased circulating follicle stimulating hormone concentration, Decr... OMIM:308750
Spinal And Bulbar Muscular Atrophy, X-Linked 1
Tremor, Decreased fertility, Testicular atrophy OMIM:313200
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Anorexia, Irritability, Abnormal fear-induced behavior, Hyperactivity, Abnormal aggressive, impul... ORPHA:3077
Spinocerebellar Ataxia 32
Infertility, Testicular atrophy, Azoospermia OMIM:613909
Spinocerebellar Ataxia Type 32
Male infertility, Testicular atrophy, Azoospermia ORPHA:276183
Kennedy Disease
Decreased fertility, Erectile dysfunction, Type II diabetes mellitus, Testicular atrophy ORPHA:481
Symptomatic Form Of Hfe-Related Hemochromatosis
Cirrhosis, Hepatomegaly, Erectile dysfunction, Arthritis, Hepatocellular carcinoma, Decreased lib... ORPHA:465508
Dyskeratosis Congenita, Autosomal Recessive 2
Cirrhosis, Nail dystrophy, Pancytopenia, Bone marrow hypocellularity, Thrombocytopenia, Testicula... OMIM:613987
Wolfram Syndrome 1
Hydroureter, Diabetes insipidus, Megaloblastic anemia, Tremor, Neurogenic bladder, Hypothyroidism... OMIM:222300
Lesch-Nyhan Syndrome
Podagra, Megaloblastic anemia, Nephrolithiasis, Dystonia, Opisthotonus, Nephrocalcinosis, Choreoa... OMIM:300322
Bone Marrow Failure Syndrome 5
Nail dystrophy, Anemia, Erythroid hypoplasia, Pure red cell aplasia, Hypogonadism, Testicular atr... OMIM:618165
Porphyria Due To Ala Dehydratase Deficiency
Agitation, Abnormal fear-induced behavior, Depression, Confusion, Restlessness, Delirium ORPHA:100924
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull
Testicular atrophy, Decreased skull ossification OMIM:601163
Gm2 Gangliosidosis, Ab Variant
Inappropriate behavior, Abnormal fear-induced behavior, Cognitive impairment ORPHA:309246
Myotonic Dystrophy 1
Hypogonadism, Frontal balding, Testicular atrophy, Cholelithiasis OMIM:160900
Aarskog-Scott Syndrome
Delayed puberty, Hyperextensibility of the finger joints, Bilateral cryptorchidism, Decreased ser... OMIM:305400
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1
Premature ovarian insufficiency, Resting tremor, Secondary amenorrhea, Hypergonadotropic hypogona... OMIM:157640
X-Linked Intellectual Disability, Snyder Type
Ectopic kidney, Hypospadias, Testicular atrophy, Camptodactyly, Osteoporosis, Synophrys, Abnormal... ORPHA:3063
Pituitary Adenoma 4, Acth-Secreting
Emotional lability, Abnormal fear-induced behavior OMIM:219090
Steinert Myotonic Dystrophy
Abnormality of thyroid physiology, Hyperinsulinemia, Decreased response to growth hormone stimula... ORPHA:273
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Abnormal fear-induced behavior, Emotional lability, Hyperactivity, Compulsive behaviors, Impulsiv... ORPHA:353281
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Abnormal fear-induced behavior, Emotional lability, Hyperactivity, Compulsive behaviors, Impulsiv... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Abnormal fear-induced behavior, Emotional lability, Hyperactivity, Compulsive behaviors, Impulsiv... ORPHA:353277


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adarb2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adarb2.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Adar3 Is Involved in Learning and Memory in Mice. Frontiers in neuroscience (April 2018) Adarb2tm1a(KOMP)Mbp PMC5914295

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Adarb2tm42060(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Adarb2tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Adarb2tm42060(L1L2_Pgk_PM) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Adarb2em1(IMPC)Tcp Exon Deletion Mice
Adarb2tm2(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Adarb2tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Adarb2tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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