Gene Summary

adenosine deaminase, RNA-specific, B2
RED2,  Adar3

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
small kidney Adarb2em1(IMPC)Tcp HOM Early adult 0.00
abnormal spleen morphology Adarb2em1(IMPC)Tcp HOM Early adult 0.00
small testis Adarb2em1(IMPC)Tcp HOM Early adult 0.00
abnormal coat/ hair morphology Adarb2em1(IMPC)Tcp HOM Early adult 3.17×10-07
decreased bone mineral density Adarb2em1(IMPC)Tcp HOM   Early adult 6.78×10-05
limb grasping Adarb2em1(IMPC)Tcp HOM Early adult 2.26×10-06
preweaning lethality, incomplete penetrance Adarb2em1(IMPC)Tcp HET   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Skull Lateral Orientation

10 Images

Eye Morphology

Images Ophthalmoscopy

4 Images


XRay Images Whole Body Dorso Ventral

10 Images



1 Images

Gross Pathology and Tissue Collection


8 Images


Panel A FCS file(s)

6 Images


XRay Images Skull Dorso Ventral Orientation

10 Images


XRay Images Whole Body Lateral Orientation

10 Images


Panel B FCS file(s)

6 Images

Human diseases caused by Adarb2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Adarb2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Severe Primary Trimethylaminuria
Negative affectivity, Low self esteem, Aggressive behavior, Depression, Emotional lability, Anxiety ORPHA:468726
Panic Disorder 1
Anxiety OMIM:167870
Mental Retardation, Autosomal Recessive 25
Anxiety OMIM:614346
Familial Alzheimer-Like Prion Disease
Deficit in phonologic short-term memory, Depression, Emotional lability, Anxiety, Cognitive impai... ORPHA:280397
Obsessive-Compulsive Disorder
Skin-picking, Anxiety, Depression OMIM:164230
Intellectual Developmental Disorder, X-Linked 63
Anxiety OMIM:300387
Geniospasm 1
Anxiety OMIM:190100
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Inertia, Dementia, Apathy, Frontotemporal dementia, Motor deterioration, Anxiety, Inappropriate b... ORPHA:412066
Hypogonadism, Male
Hypospadias, Testicular atrophy, Male hypogonadism, Micropenis OMIM:241100
Childhood Disintegrative Disorder
Dementia, Abnormal emotion/affect behavior, Social and occupational deterioration, Motor deterior... ORPHA:168782
Huntington Disease-Like 2
Dementia, Depression, Apathy, Irritability, Anxiety OMIM:606438
Isolated Follicle Stimulating Hormone Deficiency
Gonadotropin deficiency, Male hypogonadism, Hyperplasia of the Leydig cells, Bilateral breast hyp... ORPHA:52901
Claustrophobia, Depression, Agoraphobia, Separation insecurity, Emotional lability, Impulsivity, ... ORPHA:66624
Basal Ganglia Calcification, Idiopathic, 5
Dementia, Depression, Apathy, Anxiety, Cognitive impairment OMIM:615483
Dyskeratosis Congenita, Autosomal Recessive 2
Cirrhosis, Thrombocytopenia, Pancytopenia, Testicular atrophy, Bone marrow hypocellularity, Nail ... OMIM:613987
Hemochromatosis, Type 1
Osteoporosis, Cirrhosis, Azoospermia, Amenorrhea, Hepatocellular carcinoma, Impotence, Hepatomega... OMIM:235200
Bone Marrow Failure Syndrome 5
Hypogonadism, Testicular atrophy, Pure red cell aplasia, Anemia OMIM:618165
Isolated Splenogonadal Fusion
Hydrocele testis, Abnormality of the scrotum, Abnormal penis morphology, Polysplenia, Bilateral c... ORPHA:457083
Spermatogenic Failure, X-Linked, 2
Testicular atrophy, Male infertility, Azoospermia OMIM:309120
Early-Onset Schizophrenia
Low self esteem, Depression, Abnormal emotion/affect behavior, Impairment in personality function... ORPHA:96369
Spinal And Bulbar Muscular Atrophy, X-Linked 1
Tremor, Testicular atrophy, Decreased fertility OMIM:313200
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Cryptorchidism, Decreased circulating follicle stimulating hormone concentration, Azoospermia, De... OMIM:308700
Spinocerebellar Ataxia 32
Infertility, Testicular atrophy, Azoospermia OMIM:613909
Kallmann Syndrome With Spastic Paraplegia
Cryptorchidism, Decreased circulating follicle stimulating hormone concentration, Decreased circu... OMIM:308750
Kennedy Disease
Erectile dysfunction, Testicular atrophy, Decreased fertility, Type II diabetes mellitus ORPHA:481
Spinocerebellar Ataxia Type 32
Testicular atrophy, Male infertility, Azoospermia ORPHA:276183
Symptomatic Form Of Hemochromatosis Type 1
Osteoporosis, Infertility, Cirrhosis, Amenorrhea, Erectile dysfunction, Hepatocellular carcinoma,... ORPHA:465508
Wolfram Syndrome 1
Neurogenic bladder, Tremor, Hydroureter, Megaloblastic anemia, Hypothyroidism, Sideroblastic anem... OMIM:222300
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull
Testicular atrophy, Decreased skull ossification OMIM:601163
Myotonic Dystrophy 1
Hypogonadism, Frontal balding, Testicular atrophy, Cholelithiasis OMIM:160900
Lesch-Nyhan Syndrome
Megaloblastic anemia, Podagra, Opisthotonus, Testicular atrophy, Hyperuricosuria, Nephrolithiasis OMIM:300322
Aarskog-Scott Syndrome
Cryptorchidism, Elevated circulating luteinizing hormone level, Joint laxity, Widow's peak, Bilat... OMIM:305400
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1
Hypergonadotropic hypogonadism, Resting tremor, Primary amenorrhea, Testicular atrophy, Secondary... OMIM:157640
X-Linked Intellectual Disability, Snyder Type
Osteoporosis, Cryptorchidism, Sparse eyebrow, Abnormality of the Leydig cells, Camptodactyly, Rec... ORPHA:3063
Steinert Myotonic Dystrophy
Male hypogonadism, Hyperinsulinemia, Hypergonadotropic hypogonadism, Endometrial carcinoma, Impot... ORPHA:273


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adarb2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adarb2.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Adar3 Is Involved in Learning and Memory in Mice. Frontiers in neuroscience (April 2018) Adarb2tm1a(KOMP)Mbp PMC5914295

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MGI Allele Allele Type Produced
Adarb2tm2(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Adarb2tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Adarb2tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Adarb2tm42060(L1L2_Pgk_PM) Targeting vectors
Adarb2tm42060(L1L2_gt1) Targeting vectors
Adarb2em1(IMPC)Tcp Exon Deletion Mice

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