Hycc1 | hyccin PI4KA lipid kinase complex subunit 1

GeneMGI:2149839Synonyms: Fam126a, hyccin

Physiological systems

23 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Endocrine/exocrine gland Digestive/alimentary Respiratory system Hematopoietic system Behavior/neurological Cardiovascular system

15 No significant impact

1 Not tested

Gene metrics:16Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

dilated heart left ventricle4 supporting datasetsHycc1em1(IMPC)CcpczhomozygoteEarly adult5.53x10-6 
enlarged thymus1 supporting datasetHycc1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
increased mean corpuscular hemoglobin1 supporting datasetHycc1em1(IMPC)CcpczhomozygoteEarly adult2.55x10-5 
decreased circulating total protein level1 supporting datasetHycc1em1(IMPC)CcpczhomozygoteEarly adult1.41x10-5 
increased fasting circulating glucose level1 supporting datasetHycc1em1(IMPC)CcpczhomozygoteEarly adult1.73x10-12 
increased cardiac stroke volume1 supporting datasetHycc1em1(IMPC)CcpczhomozygoteEarly adult3.42x10-5 
increased circulating potassium level1 supporting datasetHycc1em1(IMPC)CcpczhomozygoteEarly adult2.45x10-7 
increased monocyte cell number1 supporting datasetHycc1em1(IMPC)CcpczhomozygoteEarly adult4.14x10-5 
abnormal inspiratory capacity1 supporting datasetHycc1em1(IMPC)CcpczhomozygoteEarly adult4.44x10-6 
abnormal salivary gland morphology1 supporting datasetHycc1em1(IMPC)CcpczhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Hycc1em1(IMPC)CcpczExon Deletionmouse
Hycc1tm40799(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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