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Gene: Gpank1 MGI:2148975

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Gene Summary

Name:
G patch domain and ankyrin repeats 1
Synonyms:
D17H6S54E,  Bat4,  G5

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased pulmonary ventilation Gpank1tm1.1(KOMP)Vlcg HOM Early adult 1.51×10-05
decreased pulmonary ventilation Gpank1tm1.1(KOMP)Vlcg HOM Early adult 3.59×10-05
increased tidal volume Gpank1tm1.1(KOMP)Vlcg HOM Early adult 8.32×10-08

Download data as:  TSV  XLS

Select physiological systems to view:
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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Blood N/A heterozygote 0.0% (0 of 2)
Bone marrow N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 100% (2 of 2)
Brainstem N/A heterozygote Not available
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote Not available
Cecum N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote Not available
Chest bone N/A heterozygote Not available
Colon N/A heterozygote 50% (1 of 2)
Diaphragm N/A heterozygote 0.0% (0 of 2)
Duodenum N/A heterozygote 0.0% (0 of 2)
Epididymis N/A heterozygote 50% (1 of 2)
Esophagus N/A heterozygote 50% (1 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote Not available
Gonadal fat pad N/A heterozygote 0.0% (0 of 2)
Harderian gland N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote Not available
Hindlimb N/A heterozygote Not available
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Ileum N/A heterozygote 50% (1 of 2)
Jejunum N/A heterozygote 0.0% (0 of 2)
Kidney N/A heterozygote 0.0% (0 of 2)
Large intestine N/A heterozygote 50% (1 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote Not available
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric adipose tissue N/A heterozygote 0.0% (0 of 2)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 2)
Midbrain N/A heterozygote 50% (1 of 2)
Olfactory lobe N/A heterozygote 50% (1 of 2)
Ovary N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Parotid gland N/A heterozygote 0.0% (0 of 2)
Penis N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote Not available
Peyer's patch N/A heterozygote Not available
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote 50% (1 of 2)
Quadriceps N/A heterozygote 0.0% (0 of 2)
Sciatic nerve N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote Not available
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 50% (1 of 2)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach pyloric region N/A heterozygote Not available
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote Not available
Sublingual gland N/A heterozygote 0.0% (0 of 2)
Submandibular gland N/A heterozygote 0.0% (0 of 2)
Testis N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Tongue N/A heterozygote 50% (1 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Trigeminal V nerve N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vagina N/A heterozygote 0.0% (0 of 2)
Vas deferens N/A heterozygote 50% (1 of 2)
Vascular system N/A heterozygote Not available
Vesicular gland N/A heterozygote 0.0% (0 of 2)
White adipose tissue N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood
bone marrow
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cecum 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
chest bone
colon
diaphragm 0.0%
duodenum 0.0%
epididymis Unavailable
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland
heart 0.0%
hindlimb 0.0%
hippocampus 0.0%
hypothalamus 0.0%
ileum 0.0%
jejunum
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node
midbrain 0.0%
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
stomach pyloric region 0.0%
striatum 0.0%
sublingual gland 0.0%
submandibular gland 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
tongue 0.0%
trachea 0.0%
trigeminal v nerve 0.0%
urinary bladder
uterus 0.0%
vagina 0.0%
vas deferens Unavailable
vascular system 0.0%
vesicular gland Unavailable
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Section

14 Images

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X-ray

XRay Images Forepaw

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Hind Leg and Hip

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Human diseases caused by Gpank1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpank1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Obesity-Hypoventilation Syndrome
Hypoventilation OMIM:257500
Athabaskan Brainstem Dysgenesis Syndrome
Central hypoventilation OMIM:601536
Central Hypoventilation Syndrome, Congenital, 3
Central hypoventilation OMIM:619483
Ullrich Congenital Muscular Dystrophy 2
Nocturnal hypoventilation OMIM:616470
Joubert Syndrome 17
Hyperventilation OMIM:614615
Mitochondrial Complex I Deficiency, Nuclear Type 9
Hypoventilation OMIM:618232
Perry Syndrome
Central hypoventilation ORPHA:178509
Chronic Pneumonitis Of Infancy
Hyperventilation ORPHA:91359
Postpoliomyelitis Syndrome
Hypoventilation ORPHA:2942
Pitt-Hopkins-Like Syndrome 2
Hyperventilation OMIM:614325
Neurodevelopmental Disorder With Poor Language And Loss Of Hand Skills
Hyperventilation OMIM:617903
Perry Syndrome
Hypoventilation, Central hypoventilation OMIM:168605
Adult-Onset Cervical Dystonia, Dyt23 Type
Hyperventilation ORPHA:420492
Fructose-1,6-Bisphosphatase Deficiency
Hyperventilation OMIM:229700
Joubert Syndrome 8
Hyperventilation OMIM:612291
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
Hyperventilation ORPHA:98784
Childhood Absence Epilepsy
Hyperventilation ORPHA:64280
Pitt-Hopkins-Like Syndrome 1
Hyperventilation OMIM:610042
Myasthenic Syndrome, Congenital, 20, Presynaptic
Hypoventilation OMIM:617143
Holocarboxylase Synthetase Deficiency
Hyperventilation OMIM:253270
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hyperventilation OMIM:618775
Central Hypoventilation Syndrome, Congenital, 1
Nocturnal hypoventilation, Hypoventilation, Central hypoventilation OMIM:209880
Mitochondrial Complex Iv Deficiency, Nuclear Type 23
Hypoventilation OMIM:620275
Developmental And Epileptic Encephalopathy 2
Hyperventilation OMIM:300672
Muscular Dystrophy, Duchenne Type
Hypoventilation OMIM:310200
Encephalitis Lethargica
Hyperventilation ORPHA:83600
Rett Syndrome
Intermittent hyperventilation OMIM:312750
Congenital Disorder Of Glycosylation, Type Iib
Hypoventilation OMIM:606056
Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To 5Q31.3 Microdeletion
Hypoventilation ORPHA:314655
Cntnap2-Related Developmental And Epileptic Encephalopathy
Intermittent hyperventilation ORPHA:163681
Cholera
Hyperventilation ORPHA:173
Bethlem Muscular Dystrophy
Hypoventilation ORPHA:610
Fructose-1,6-Bisphosphatase Deficiency
Intermittent hyperventilation ORPHA:348
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Hypoventilation OMIM:618493
Rabin-Pappas Syndrome
Hypoventilation OMIM:620155
Biotinidase Deficiency
Hyperventilation ORPHA:79241
Intellectual Developmental Disorder, Autosomal Dominant 57
Hyperventilation OMIM:618050
Intellectual Developmental Disorder With Microcephaly And Pontine And Cerebellar Hypoplasia
Intermittent hyperventilation OMIM:300749
Synaptic Congenital Myasthenic Syndromes
Hypoventilation ORPHA:98915
Intellectual Developmental Disorder, Autosomal Dominant 54
Hyperventilation OMIM:617799
Infantile Hypotonia-Oculomotor Anomalies-Hyperkinetic Movements-Developmental Delay Syndrome
Hyperventilation ORPHA:522077
Proximal Spinal Muscular Atrophy
Hypoventilation ORPHA:70
Mogs-Cdg
Hypoventilation ORPHA:79330
Pitt-Hopkins Syndrome
Intermittent hyperventilation OMIM:610954
Pitt-Hopkins Syndrome
Hyperventilation ORPHA:2896
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Aspiration, Hypoventilation ORPHA:258
Mitochondrial Dna-Associated Leigh Syndrome
Hyperventilation ORPHA:255210
Prader-Willi Syndrome
Hypoventilation OMIM:176270
Cocaine Intoxication
Hyperventilation ORPHA:90068
Charcot-Marie-Tooth Disease Type 4C
Hypoventilation ORPHA:99949
Central Hypoventilation Syndrome, Congenital, 2, And Autonomic Dysfunction
Hypoventilation OMIM:619482
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Hypoventilation OMIM:203700
Acute Liver Failure
Hyperventilation ORPHA:90062
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Hypoventilation, Central hypoventilation ORPHA:293987
Neurodevelopmental Disorder With Hypotonia And Speech Delay, With Or Without Seizures
Hypoventilation OMIM:620455
Autosomal Recessive Polycystic Kidney Disease
Hypoventilation ORPHA:731
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Hypoventilation ORPHA:438213
Pallister-Killian Syndrome
Hyperventilation OMIM:601803

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpank1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpank1.

No publications found that use IMPC mice or data for Gpank1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Gpank1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Gpank1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Gpank1tm232439(L1L2_Bact_P) Reporter-tagged deletion allele (with selection cassette) Targeting vectors

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