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Gene: Magee2 MGI:2148316

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Gene Summary

Name:
MAGE family member E2
Synonyms:
9630059J11Rik,  Mage-e2

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Magee2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Magee2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 2, With Impaired Intellectual Development
Hypoplasia of the pons, Midline brainstem cleft, Agenesis of corpus callosum, Abnormality of the ... OMIM:617542
Lissencephaly 9 With Complex Brainstem Malformation
Hypoplasia of the corpus callosum, Enlarged tectum, Cerebellar vermis hypoplasia, Cerebellar hemi... OMIM:618325
Fibrosis Of Extraocular Muscles, Congenital, 3A, With Or Without Extraocular Involvement
Hypoplasia of the corpus callosum, Dysgenesis of the basal ganglia, Hypoplastic anterior commissu... OMIM:600638
Joubert Syndrome 13
Cerebellar vermis hypoplasia, Molar tooth sign on MRI, Pachygyria OMIM:614173
Cortical Dysgenesis With Pontocerebellar Hypoplasia Due To Tubb3 Mutation
Hypoplasia of the corpus callosum, Lissencephaly, Cerebellar vermis hypoplasia, Primary microceph... ORPHA:300570
Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome
Thin corpus callosum, Aplasia/Hypoplasia of the cerebellum, Pachygyria, Abnormality of the anteri... ORPHA:572013
Joubert Syndrome 30
Molar tooth sign on MRI, Dandy-Walker malformation, Polymicrogyria, Cerebellar atrophy, Agenesis ... OMIM:617622
Septopreoptic Holoprosencephaly
Megalencephaly, Abnormal septum pellucidum morphology, Rhombencephalosynapsis, Abnormal corpus ca... ORPHA:280195
Hydrolethalus Syndrome 2
Molar tooth sign on MRI, Anencephaly, Agenesis of corpus callosum OMIM:614120
Neurodevelopmental Disorder With Or Without Anomalies Of The Brain, Eye, Or Heart
Hypoplasia of the corpus callosum, Cerebellar vermis hypoplasia, Hypoplastic anterior commissure,... OMIM:616975
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Enlarged cerebellum, Hypoplasia of the corpus callosum, Secondary microcephaly, Chiari type I mal... ORPHA:261552

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Magee2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Magee2.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Positively Selected MAGEE2 LoF Allele Is Associated with Sexual Dimorphism in Human Brain Size and Shows Similar Phenotypes in Magee2 Null Mice. Molecular biology and evolution (December 2021) Magee2em1(IMPC)Wtsi PMC8662591
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Magee2em1(IMPC)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Magee2em1(IMPC)Wtsi PMC6671969

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Magee2tm456226(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Magee2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Magee2em1(IMPC)Wtsi Deletion Mice
Magee2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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