Genes Phenotypes

Gene: Tmem132a

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Name
transmembrane protein 132A
MGI ID
MGI:2147810
Synonyms
6720481D13Rik Hspa5bp1
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (19) Measurements chart (238) All data table (660)
Expression & images (113) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
spina bifida Tmem132atm1b(KOMP)Wtsi HOM E15.5 0.00
abnormal tail morphology Tmem132atm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal neural tube closure Tmem132atm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal limb morphology Tmem132atm1b(KOMP)Wtsi HOM E18.5 0.00
spina bifida Tmem132atm1b(KOMP)Wtsi HOM E18.5 0.00
abnormal limb bud morphology Tmem132atm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal bone structure Tmem132atm1b(KOMP)Wtsi HET Early adult 5.31×10-07
abnormal cranium morphology Tmem132atm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal limb morphology Tmem132atm1b(KOMP)Wtsi HOM E15.5 0.00
abnormal embryo size Tmem132atm1b(KOMP)Wtsi HOM E18.5 0.00
preweaning lethality, complete penetrance Tmem132atm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal head shape Tmem132atm1b(KOMP)Wtsi HOM E18.5 0.00
increased total body fat amount Tmem132atm1b(KOMP)Wtsi HET Early adult 4.02×10-05
abnormal craniofacial morphology Tmem132atm1b(KOMP)Wtsi HOM E12.5 0.00
syndactyly Tmem132atm1b(KOMP)Wtsi HOM E15.5 0.00
abnormal facial morphology Tmem132atm1b(KOMP)Wtsi HOM E18.5 0.00
syndactyly Tmem132atm1b(KOMP)Wtsi HOM E18.5 0.00
decreased bone mineral content Tmem132atm1b(KOMP)Wtsi HET Early adult 7.95×10-07
abnormal tail morphology Tmem132atm1b(KOMP)Wtsi HOM E18.5 0.00

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/379) N/A
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Trigeminal V nerve 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vas deferens 2 No  (15/388) N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
digestive system (1)
Oral epithelium expression
Skin expression
MA:0000344
MA:0000151
integumental system (3)
Oral epithelium expression
Skin expression
MA:0000344
MA:0000151
nervous system (1)
Cerebral Cortex expression
Brain expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Cerebellum expression
Brainstem expression
Olfactory Lobe expression
MA:0000185
MA:0000168
MA:0000891
MA:0000191
MA:0000173
MA:0000198
MA:0000169
MA:0002413
postnatal mouse (7)
Cerebral Cortex expression
Brain expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Cerebellum expression
Brainstem expression
Olfactory Lobe expression
MA:0000185
MA:0000168
MA:0000891
MA:0000191
MA:0000173
MA:0000198
MA:0000169
MA:0002413
reproductive system (2)
Oviduct tissue not available
MA:0000385
respiratory system (1)
Oral epithelium expression
Skin expression
MA:0000344
MA:0000151
trunk (3)
Kidney expression
MA:0000368
urinary system (1)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 4  (1/57)  (4/4) N/A
Axial skeleton 4  (1/61)  (4/4) N/A
Brain 4  (6/504)  (4/4) N/A
Central nervous system ganglion 4  (1/70)  (4/4) N/A
Cranium 4  (1/61)  (4/4) N/A
Dorsal root ganglion 4  (1/57)  (4/4) N/A
Ear 4  (1/504)  (4/4) N/A
Embryo 4  (1/505)  (4/4) N/A
Outer ear 4  (1/66)  (4/4) N/A
Eye 4  (1/504)  (4/4) N/A
Femur pre-cartilage condensation 4  (1/52)  (4/4) N/A
Foot 4  (1/504)  (4/4) N/A
Forearm 4  (1/297)  (4/4) N/A
Forebrain 4  (1/504)  (4/4) N/A
Forelimb 4  (1/504)  (4/4) N/A
Fronto-nasal process 4  (1/58)  (4/4) N/A
Gut 4  (1/56)  (4/4) N/A
Hand 4  (1/503)  (4/4) N/A
Head 4  (5/504)  (4/4) N/A
Head mesenchyme 4  (1/57)  (4/4) N/A
Heart 4  (1/504)  (4/4) N/A
Heart ventricle 4  (1/57)  (4/4) N/A
Hindbrain 4  (6/504)  (4/4) N/A
Hindlimb 4  (1/503)  (4/4) N/A
Humerus pre-cartilage condensation 4  (1/61)  (4/4) N/A
Inner ear 4  (1/61)  (4/4) N/A
Intestine 4  (1/55)  (3/4) N/A
Liver 4  (1/504)  (4/4) N/A
Lower leg 4  (1/297)  (4/4) N/A
Lung 4  (1/500)  (4/4) N/A
Mandibular process 4  (1/504)  (4/4) N/A
Maxillary process 4  (1/504)  (4/4) N/A
Mesonephros of female 4  (1/52)  (4/4) N/A
Mesonephros of male 4  (1/52)  (4/4) N/A
Metanephros 4  (1/52)  (4/4) N/A
Midbrain 4  (1/504)  (4/4) N/A
Nasal septum 4  (1/57)  (4/4) N/A
Nose 4  (1/70)  (4/4) N/A
Notochord 4  (1/57)  (4/4) N/A
Oral cavity 4  (1/504)  (4/4) N/A
Outflow tract 4  (1/57)  (4/4) N/A
Pancreas 4  (1/52)  (4/4) N/A
Pericardium 4  (1/52)  (4/4) N/A
Pharynx 4  (1/52)  (4/4) N/A
Radius-ulna pre-cartilage condensation 4  (1/61)  (4/4) N/A
Rib pre-cartilage condensation 4  (1/54)  (4/4) N/A
Skeleton 4  (1/70)  (4/4) N/A
Skin 4  (1/504)  (4/4) N/A
Spinal cord 4  (1/69)  (4/4) N/A
Stomach 4  (1/52)  (4/4) N/A
Tail 4  (1/504)  (4/4) N/A
Tail somite 4  (1/504)  (4/4) N/A
Thoracic vertebral cartilage condensation 4  (1/52)  (4/4) N/A
Tongue 4  (1/52)  (4/4) N/A
Trachea 4  (1/56)  (4/4) N/A
Trunk mesenchyme 4  (1/57)  (4/4) N/A
Umbilical artery embryonic part 4  (1/57)  (4/4) N/A
Umbilical vein embryonic part 4  (1/57)  (4/4) N/A
Upper arm 4  (1/297)  (4/4) N/A
Upper leg 4  (1/297)  (4/4) N/A
Urinary system 4  (1/56)  (4/4) N/A
Vibrissa 4  (1/66)  (4/4) N/A

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
16 Images
X-ray: XRay Images Forepaw
16 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
X-ray: XRay Images Skull Lateral Orientation
16 Images
X-ray: XRay Images Whole Body Lateral Orientation
16 Images
Embryo LacZ: LacZ images wholemount
4 Images
Adult LacZ: LacZ Images Wholemount
7 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Tmem132atm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Tmem132atm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Tmem132atm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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