Gene: Patl1

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Name
protein associated with topoisomerase II homolog 1 (yeast)
MGI ID
MGI:2147679
Synonyms
Pat1b
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
unresponsive to tactile stimuli Patl1tm1b(EUCOMM)Wtsi HET E18.5 0.00
decreased prepulse inhibition Patl1tm1b(EUCOMM)Wtsi HET Early adult 1.92×10-09
decreased fasting circulating glucose level Patl1tm1b(EUCOMM)Wtsi HET Early adult 2.54×10-05
preweaning lethality, incomplete penetrance Patl1tm1b(EUCOMM)Wtsi HOM   Early adult 0.00
preweaning lethality, complete penetrance Patl1tm1b(EUCOMM)Wtsi HOM Early adult 0.00
decreased circulating bilirubin level Patl1tm1b(EUCOMM)Wtsi HET   Early adult 8.64×10-05
decreased grip strength Patl1tm1b(EUCOMM)Wtsi HET Early adult 4.31×10-18
increased circulating chloride level Patl1tm1b(EUCOMM)Wtsi HET   Early adult 2.65×10-08
tremors Patl1tm1b(EUCOMM)Wtsi HET   Early adult 6.26×10-05
unresponsive to tactile stimuli Patl1tm1b(EUCOMM)Wtsi HOM E18.5 0.00

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/584) N/A
Aorta 2 No  (1/584) N/A
Bone 2 No N/A
Brain 2 No  (4/584) N/A
Brainstem 2 No  (2/584) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/584) N/A
Cecum 2 No  (11/370) N/A
Cerebellum 2 No  (3/584) N/A
Cerebral cortex 2 No  (2/584) N/A
Esophagus 2 No  (7/408) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/584)  (2/2)  Wholemount images
Hippocampus 2 No  (3/584) N/A
Hypothalamus 2 No  (2/584) N/A
Kidney 2 No  (21/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/584) N/A
Lung 2 No  (2/584) N/A
Lymph node 2 No  (1/584) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/584) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  Wholemount images
Pancreas 2 No  (5/584)  Wholemount images
Parathyroid gland 2 No  (1/562) N/A
Peripheral nervous system 2 No  (2/584) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/584) N/A
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (1/584) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (3/584) N/A
Spleen 2 No  (3/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (3/584) N/A
Testis 2 No  (6/584)  (1/2)  Wholemount images
Thymus 2 No  (1/584) N/A
Thyroid gland 2 No  (16/584) N/A
Trachea 2 No  (3/584) N/A
Trigeminal V nerve 2 No N/A
Uterus 2 No N/A
Vas deferens 2 No  (14/381)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Atrium 2  (1/59) N/A
Axial skeleton 2  (1/63) N/A
Brain 2  (6/507)  (2/2) N/A
Central nervous system ganglion 2  (1/72)  (2/2) N/A
Cranium 2  (1/63) N/A
Dorsal root ganglion 2  (1/59)  (2/2) N/A
Ear 2  (1/507)  (2/2) N/A
Embryo 2  (1/508)  (2/2) N/A
External ear 2  (1/73) N/A
Eye 2  (1/507)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/54) N/A
Footplate 2  (1/507) N/A
Forearm 2  (1/304) N/A
Forebrain 2  (1/507)  (2/2) N/A
Forelimb 2  (1/507) N/A
Fronto-nasal process 2  (1/60) N/A
Gut 2  (1/58)  (2/2) N/A
Handplate 2  (1/507) N/A
Head 2  (5/507)  (2/2) N/A
Head mesenchyme 2  (1/59)  (2/2) N/A
Heart 2  (1/507)  (2/2) N/A
Heart ventricle 2  (1/59)  (2/2) N/A
Hindbrain 2  (6/507)  (2/2) N/A
Hindlimb 2  (1/507) N/A
Humerus pre-cartilage condensation 2  (1/63) N/A
Inner ear 2  (1/63)  (2/2) N/A
Intestine 2  (1/57)  (2/2) N/A
Liver 2  (1/502)  (2/2) N/A
Lower leg 2  (1/304) N/A
Lung 2  (1/502)  (2/2) N/A
Mandibular process 2  (1/507) N/A
Maxillary process 2  (1/507) N/A
Mesonephros of female 2  (1/54) N/A
Mesonephros of male 2  (1/54) N/A
Metanephros 2  (1/54) N/A
Midbrain 2  (1/507) N/A
Nasal septum 2  (1/59) N/A
Nose 2  (1/77) N/A
Notochord 2  (1/59)  (2/2) N/A
Oral cavity 2  (1/502)  (2/2) N/A
Outflow tract 2  (1/59) N/A
Pancreas 2  (1/54)  (2/2) N/A
Pericardium 2  (1/54)  (2/2) N/A
Pharynx 2  (1/55) N/A
Radius-ulna pre cartilage condensation 2  (1/63) N/A
Rib pre-cartilage condensation 2  (1/56) N/A
Skeleton 2  (1/77) N/A
Skin 2  (1/507) N/A
Spinal cord 2  (1/71)  (2/2) N/A
Stomach 2  (1/54)  (2/2) N/A
Tail 2  (1/507) N/A
Tail somite group 2  (1/507) N/A
Thoracic vertebral cartilage condensation 2  (1/54) N/A
Tongue 2  (1/54) N/A
Trachea 2  (1/58)  (2/2) N/A
Trunk mesenchyme 2  (1/59)  (2/2) N/A
Umbilical artery embryonic part 2  (1/59) N/A
Umbilical vein embryonic part 2  (1/59) N/A
Upper arm 2  (1/304) N/A
Upper leg 2  (1/304) N/A
Urinary system 2  (1/58) N/A
Vibrissa 2  (1/73) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
X-ray: XRay Images Skull Lateral Orientation
9 Images
X-ray: XRay Images Whole Body Dorso Ventral
9 Images
X-ray: XRay Images Forepaw
9 Images
Adult LacZ: LacZ Images Wholemount
6 Images
X-ray: XRay Images Whole Body Lateral Orientation
9 Images
Embryo LacZ: LacZ images wholemount
4 Images
Immunophenotyping: Panel A FCS file(s)
6 Images
Immunophenotyping: Panel B FCS file(s)
6 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Patl1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Patl1tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Patl1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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