Gene: Afap1l2

Name
actin filament associated protein 1-like 2
MGI ID
MGI:2147658
Synonyms
N/A
Viability
N/A
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal behavior Afap1l2tm1b(KOMP)Wtsi HOM postnatal 7.90×10-05
decreased heart rate Afap1l2tm1b(KOMP)Wtsi HOM postnatal 9.32×10-05
increased lean body mass Afap1l2tm1b(KOMP)Wtsi HOM postnatal 2.57×10-05
abnormal spleen morphology Afap1l2tm1b(KOMP)Wtsi HOM postnatal 0.00
decreased circulating insulin level Afap1l2tm1b(KOMP)Wtsi HOM postnatal 1.34×10-06
increased circulating alkaline phosphatase level Afap1l2tm1b(KOMP)Wtsi HOM postnatal 6.60×10-05
hypoactivity Afap1l2tm1b(KOMP)Wtsi HOM postnatal 9.67×10-06
improved glucose tolerance Afap1l2tm1b(KOMP)Wtsi HOM postnatal 1.89×10-07
long tibia Afap1l2tm1b(KOMP)Wtsi HOM postnatal 9.19×10-05
decreased total body fat amount Afap1l2tm1b(KOMP)Wtsi HOM postnatal 3.36×10-08
prolonged RR interval Afap1l2tm1b(KOMP)Wtsi HOM postnatal 8.43×10-05
abnormal coat/ hair morphology Afap1l2tm1b(KOMP)Wtsi HOM postnatal 5.53×10-13

Download data as:  TSV  XLS

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584)  (2/4) N/A
Aorta 4 No N/A
Blood 4 No N/A
Bone marrow 4 No N/A
Brain 4 No  (2/4) N/A
Brainstem 4 No N/A
Brown adipose tissue 4 No  (2/4) N/A
Cartilage tissue 4 No N/A
Cecum 4 No  (12/383)  (2/4) N/A
Cerebellum 4 No  (4/4) N/A
Cerebral cortex 4 No N/A
Chest bone 4 No  (2/4) N/A
Colon 4 No  (12/127)  (2/4) N/A
Diaphragm 4 No  (1/4) N/A
Duodenum 4 No  (2/127)  (2/4) N/A
Epididymis 4 No  (18/134)  (2/4) N/A
Esophagus 4 No  (7/415)  (4/4) N/A
Eye 4 No  (1/4) N/A
Gall bladder 4 No N/A
Gonadal fat pad 4 No  (1/4) N/A
Harderian gland 4 No  (2/4) N/A
Heart 4 No N/A
Hindlimb 4 No N/A
Hippocampus 4 No N/A
Hypothalamus 4 No N/A
Ileum 4 No  (14/127)  (4/4) N/A
Jejunum 4 No  (6/127)  (2/4) N/A
Kidney 4 No  (18/584)  (4/4) N/A
Large intestine 4 No  (10/584) N/A
Liver 4 No N/A
Lower urinary tract 4 No N/A
Lung 4 No N/A
Lymph node 4 No N/A
Mammary gland 4 No N/A
Mesenteric adipose tissue 4 No  (3/4) N/A
Mesenteric lymph node 4 No  (2/4) N/A
Midbrain 4 No  (4/4) N/A
Olfactory lobe 4 No  (3/4) N/A
Ovary 4 No  (1/584)  (1/4) N/A
Oviduct 4 No  (1/4) N/A
Pancreas 4 No  (5/584)  (2/4) N/A
Parathyroid gland 4 No N/A
Parotid gland 4 No N/A
Penis 4 No  (2/4) N/A
Peripheral nervous system 4 No N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No N/A
Prostate gland 4 No  (12/584)  (1/4) N/A
Quadriceps 4 No  (3/4) N/A
Sciatic nerve 4 No  (4/4) N/A
Skeletal muscle 4 No N/A
Skin 4 No  (4/4) N/A
Small intestine 4 No  (9/584) N/A
Spinal cord 4 No  (4/4) N/A
Spleen 4 No  (2/584)  (3/4) N/A
Stomach 4 No  (12/584)  (4/4) N/A
Stomach pyloric region 4 No N/A
Striatum 4 No N/A
Sublingual gland 4 No N/A
Submandibular gland 4 No  (2/132)  (1/4) N/A
Testis 4 No  (2/584)  (2/4) N/A
Thymus 4 No  (2/4) N/A
Thyroid gland 4 No  (15/584)  (4/4) N/A
Tongue 4 No  (5/127)  (4/4) N/A
Trachea 4 No  (3/4) N/A
Trigeminal V nerve 4 No  (2/4) N/A
Urinary bladder 4 No  (4/4) N/A
Uterus 4 No  (2/4) N/A
Vagina 4 No  (1/4) N/A
Vas deferens 4 No  (15/388)  (2/4) N/A
Vascular system 4 No N/A
Vesicular gland 4 No  (2/4) N/A
White adipose tissue 4 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Lateral Orientation
20 Images
X-ray: XRay Images Dorso Ventral
40 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Afap1l2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Afap1l2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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