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Gene: Otub1

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Name
OTU domain, ubiquitin aldehyde binding 1
MGI ID
MGI:2147616
Synonyms
N/A
Viability
Data available
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (7) Measurements chart (272) All data table (1034)
Expression & images (68) Disease models (0) Histopathology (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Otub1tm1b(EUCOMM)Hmgu HOM   Early adult 0.00
abnormal heart position or orientation Otub1tm1b(EUCOMM)Hmgu HET Early adult 0.00
abnormal cranium morphology Otub1tm1b(EUCOMM)Hmgu HET   Early adult 8.13×10-05
abnormal lung morphology Otub1tm1b(EUCOMM)Hmgu HET Early adult 0.00
decreased large unstained cell number Otub1tm1b(EUCOMM)Hmgu HET   Early adult 2.81×10-05
hypoactivity Otub1tm1b(EUCOMM)Hmgu HET Early adult 2.66×10-05
decreased grip strength Otub1tm1b(EUCOMM)Hmgu HET Early adult 6.11×10-06

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/584)  (2/2)  Wholemount images
Aorta 2 No  (1/584) N/A
Bone 2 No N/A
Brain 2 No  (4/584)  (2/2)  Wholemount images
Brainstem 2 No  (2/584)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/584)  (2/2)  Wholemount images
Cerebellum 2 No  (3/584)  Wholemount images
Cerebral cortex 2 No  (2/584)  (2/2)  Wholemount images
Esophagus 2 No  (7/408) N/A
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No N/A
Heart 2 No  (2/584) N/A
Hippocampus 2 No  (3/584)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/584)  (2/2)  Wholemount images
Kidney 2 No  (21/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/584)  (2/2)  Wholemount images
Lung 2 No  (2/584) N/A
Lymph node 2 No  (1/584) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/584)  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (1/562)  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/584)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/584)  (1/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (1/584) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (3/584)  (2/2)  Wholemount images
Spleen 2 No  (3/584) N/A
Stomach 2 No  (12/584)  (1/2)  Wholemount images
Striatum 2 No  (3/584)  (2/2)  Wholemount images
Testis 2 No  (6/584)  (1/2)  Wholemount images
Thymus 2 No  (1/584) N/A
Thyroid gland 2 No  (16/584)  Wholemount images
Trachea 2 No  (3/584)  (2/2)  Wholemount images
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
digestive system (2)
Oral epithelium expression
MA:0000344
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
nervous system (5)
Brain expression
Brainstem expression
Cerebral Cortex expression
Cerebellum ambiguous
Hippocampus expression
Hypothalamus expression
Olfactory Lobe expression
Striatum expression
MA:0000191
MA:0000169
MA:0000198
MA:0000891
MA:0000168
MA:0002413
MA:0000185
MA:0000173
postnatal mouse (15)
Adrenal gland expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (2)
Oral epithelium expression
MA:0000344
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (1)
Cartilage tissue expression
MA:0000104
trunk (8)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 3  (6/507)  (3/7) N/A
Ear 3  (1/507)  (3/7) N/A
Embryo 3  (1/508)  (7/7) N/A
Eye 3  (1/507)  (7/7) N/A
Footplate 3  (1/507)  (2/7) N/A
Forebrain 3  (1/507)  (5/7) N/A
Forelimb 3  (1/507)  (5/7) N/A
Handplate 3  (1/507)  (2/7) N/A
Head 3  (5/507)  (7/7) N/A
Heart 3  (1/507)  (3/7) N/A
Hindbrain 3  (6/507)  (1/7) N/A
Hindlimb 3  (1/507)  (5/7) N/A
Liver 3  (1/502)  (1/7) N/A
Lung 3  (1/502)  (3/7) N/A
Mandibular process 3  (1/507)  (3/7) N/A
Maxillary process 3  (1/507)  (3/7) N/A
Midbrain 3  (1/507)  (1/7) N/A
Oral cavity 3  (1/502)  (3/7) N/A
Placenta 1  (7/42)  (2/2) N/A
Skin 3  (1/507)  (3/7) N/A
Tail 3  (1/507)  (3/7) N/A
Tail somite group 3  (1/507)  (1/7) N/A

 Associated Images

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Embryo LacZ: LacZ images wholemount
10 Images
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Adult LacZ: LacZ Images Wholemount
15 Images
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Echo: M-Mode Images
31 Images
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X-ray: XRay Images Whole Body Dorso Ventral
20 Images
thumbnail
X-ray: XRay Images Whole Body Lateral Orientation
20 Images
thumbnail
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Otub1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Otub1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Otub1tm83433(L1L2_Bact_P) Targeting vectors

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