Fbxo11 | F-box protein 11

GeneMGI:2147134Synonyms: Jf, GENA 104

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Digestive/alimentary Hematopoietic system Behavior/neurological Skeleton Mortality/aging

12 No significant impact

2 Not tested

Gene metrics:24Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

abnormal bone mineralization1 supporting datasetFbxo11JfheterozygoteEarly adult8.65x10-5 
decreased circulating iron level1 supporting datasetFbxo11tm2b(EUCOMM)WtsiheterozygoteEarly adult1.23x10-6 
increased startle reflex6 supporting datasetsFbxo11JfheterozygoteEarly adult1.01x10-19 
hyperactivity8 supporting datasetsFbxo11tm2b(EUCOMM)WtsiheterozygoteEarly adult6.54x10-7 
decreased prepulse inhibition4 supporting datasetsFbxo11JfheterozygoteEarly adult2.73x10-7 
decreased hemoglobin content1 supporting datasetFbxo11tm2b(EUCOMM)WtsiheterozygoteEarly adult2.28x10-11 
decreased mean corpuscular volume1 supporting datasetFbxo11JfheterozygoteEarly adult5.16x10-5 
preweaning lethality, complete penetrance1 supporting datasetFbxo11JfhomozygoteEarly adultN/A * 
decreased hematocrit1 supporting datasetFbxo11tm2b(EUCOMM)WtsiheterozygoteEarly adult3.18x10-8 
abnormal defecation1 supporting datasetFbxo11JfheterozygoteEarly adult6.95x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Fbxo11tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Fbxo11tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Fbxo11tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Fbxo11tm2b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Fbxo11tm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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