Gene: Fbxo11

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Phenotype System Allele Zyg Sex Life Stage P Value
decreased hematocrit Fbxo11tm2b(EUCOMM)Wtsi HET Early adult 8.68×10-09
abnormal retina morphology Fbxo11Jf HET Early adult 9.64×10-05
hyperactivity Fbxo11Jf HET Early adult 2.10×10-06
decreased hemoglobin content Fbxo11tm2b(EUCOMM)Wtsi HET Early adult 1.47×10-10
preweaning lethality, complete penetrance Fbxo11tm2b(EUCOMM)Wtsi HOM Early adult 0.00
decreased lean body mass Fbxo11Jf HET Early adult 5.28×10-07
abnormal defecation Fbxo11Jf HET Early adult 6.95×10-07
abnormal bone mineralization Fbxo11Jf HET Early adult 3.71×10-06
decreased circulating iron level Fbxo11tm2b(EUCOMM)Wtsi HET Early adult 3.63×10-05
decreased bone mineral density Fbxo11Jf HET Early adult 1.81×10-13
decreased erythrocyte cell number Fbxo11tm2b(EUCOMM)Wtsi HET Early adult 1.61×10-10
decreased grip strength Fbxo11Jf HET Early adult 4.37×10-05
abnormal vocalization Fbxo11Jf HET Early adult 8.78×10-05
thrombocytopenia Fbxo11Jf HET Early adult 8.24×10-11
increased total body fat amount Fbxo11Jf HET Early adult 3.34×10-12
abnormal behavior Fbxo11tm2b(EUCOMM)Wtsi HET Early adult 1.22×10-08
decreased prepulse inhibition Fbxo11Jf HET Early adult 1.75×10-11
increased lean body mass Fbxo11Jf HET Early adult 2.79×10-08
abnormal locomotor activation Fbxo11Jf HET Early adult 8.09×10-08
short tibia Fbxo11tm2b(EUCOMM)Wtsi HET Early adult 7.40×10-06
hyperactivity Fbxo11tm2b(EUCOMM)Wtsi HET Early adult 8.19×10-11
abnormal startle reflex Fbxo11Jf HET Early adult 6.68×10-12
increased startle reflex Fbxo11Jf HET Early adult 6.66×10-20
abnormal behavior Fbxo11Jf HET Early adult 7.89×10-06
decreased circulating glucose level Fbxo11Jf HET Early adult 5.89×10-05
increased red blood cell distribution width Fbxo11tm2b(EUCOMM)Wtsi HET Early adult 5.49×10-06

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No  (2/2)  Wholemount images
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584)  (2/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No  Wholemount images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (4/4) N/A
Ear 2  (1/504)  (2/4) N/A
Embryo 2  (1/505)  (4/4) N/A
Eye 2  (1/504)  (4/4) N/A
Foot 2  (1/504)  (4/4) N/A
Forebrain 2  (1/504)  (4/4) N/A
Forelimb 2  (1/504)  (4/4) N/A
Hand 2  (1/503)  (4/4) N/A
Head 2  (5/504)  (4/4) N/A
Heart 2  (1/504)  (2/4) N/A
Hindbrain 2  (6/504)  (4/4) N/A
Hindlimb 2  (1/503)  (4/4) N/A
Liver 2  (1/504)  (2/4) N/A
Lung 2  (1/500)  (2/4) N/A
Mandibular process 2  (1/504)  (2/4) N/A
Maxillary process 2  (1/504)  (2/4) N/A
Midbrain 2  (1/504)  (3/4) N/A
Oral cavity 2  (1/504)  (2/4) N/A
Skin 2  (1/504)  (2/4) N/A
Tail 2  (1/504)  (4/4) N/A
Tail somite 2  (1/504)  (4/4) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
27 Images
Echo: M-Mode Images
28 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Skull Lateral Orientation
1 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
8 Images
X-ray: XRay Images Whole Body Dorso Ventral
9 Images
X-ray: XRay Images Whole Body Lateral Orientation
9 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Fbxo11tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Fbxo11tm2b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Fbxo11tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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