Gene: Fbxo11

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Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Fbxo11Jf HET postnatal 4.37×10-05
preweaning lethality, complete penetrance Fbxo11tm2b(EUCOMM)Wtsi HOM n/a 0.00
decreased bone mineral density Fbxo11Jf HET postnatal 1.81×10-13
narrow eye opening Fbxo11tm2b(EUCOMM)Wtsi HET postnatal 8.50×10-05
abnormal behavior Fbxo11Jf HET postnatal 7.89×10-06
decreased circulating glucose level Fbxo11Jf HET postnatal 5.89×10-05
thrombocytopenia Fbxo11Jf HET postnatal 8.24×10-11
decreased hemoglobin content Fbxo11tm2b(EUCOMM)Wtsi HET postnatal 1.67×10-10
increased red blood cell distribution width Fbxo11tm2b(EUCOMM)Wtsi HET postnatal 5.30×10-06
abnormal retina morphology Fbxo11Jf HET postnatal 9.64×10-05
hyperactivity Fbxo11tm2b(EUCOMM)Wtsi HET postnatal 2.34×10-10
increased startle reflex Fbxo11Jf HET postnatal 6.66×10-20
short tibia Fbxo11tm2b(EUCOMM)Wtsi HET postnatal 3.39×10-06
decreased lean body mass Fbxo11Jf HET postnatal 5.28×10-07
abnormal startle reflex Fbxo11Jf HET postnatal 6.68×10-12
hyperactivity Fbxo11Jf HET postnatal 2.10×10-06
decreased erythrocyte cell number Fbxo11tm2b(EUCOMM)Wtsi HET postnatal 1.84×10-10
abnormal behavior Fbxo11tm2b(EUCOMM)Wtsi HET postnatal 1.43×10-08
abnormal defecation Fbxo11Jf HET postnatal 6.95×10-07
decreased prepulse inhibition Fbxo11Jf HET postnatal 1.75×10-11
increased lean body mass Fbxo11Jf HET postnatal 2.79×10-08
decreased body weight Fbxo11Jf HET postnatal 6.70×10-19
decreased circulating iron level Fbxo11tm2b(EUCOMM)Wtsi HET postnatal 7.35×10-05
abnormal vocalization Fbxo11Jf HET postnatal 8.78×10-05
abnormal locomotor activation Fbxo11Jf HET postnatal 8.09×10-08
abnormal bone mineralization Fbxo11Jf HET postnatal 3.71×10-06
decreased hematocrit Fbxo11tm2b(EUCOMM)Wtsi HET postnatal 1.08×10-08
increased total body fat amount Fbxo11Jf HET postnatal 3.34×10-12

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No  (2/2)  Wholemount images
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584)  (2/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No  Wholemount images
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Dorso Ventral
9 Images
X-ray: XRay Images Lateral Orientation
9 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
8 Images
Adult LacZ: LacZ Images Wholemount
27 Images
Echo: M-Mode Images
28 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Skull Lateral Orientation
1 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Fbxo11tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Fbxo11tm2b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Fbxo11tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells