Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased circulating triglyceride level | Osbpl11tm1b(EUCOMM)Hmgu | HET | Early adult | 1.70×10-05 | ||
improved glucose tolerance | Osbpl11tm1b(EUCOMM)Hmgu | HET | Early adult | 6.21×10-05 | ||
preweaning lethality, complete penetrance | Osbpl11tm1b(EUCOMM)Hmgu | HOM | Early adult | 2.39×10-06 | ||
increased total body fat amount | Osbpl11tm1b(EUCOMM)Hmgu | HET | Early adult | 2.66×10-06 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Osbpl11 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Type 1 Diabetes Mellitus 15 | Type I diabetes mellitus, Diabetes mellitus | OMIM:601666 | |
Lipase Deficiency, Combined | Hypertriglyceridemia, Lipodystrophy, Type II diabetes mellitus | OMIM:246650 | |
Coronary Artery Disease, Autosomal Dominant 2 | Glucose intolerance, Hypertriglyceridemia, Impaired glucose tolerance, Type II diabetes mellitus | OMIM:610947 | |
Lipodystrophy, Familial Partial, Type 1 | Loss of subcutaneous adipose tissue in limbs, Hypertriglyceridemia, Lipodystrophy, Increased subc... | OMIM:608600 | |
Obesity Due To Melanocortin 4 Receptor Deficiency | Hypertriglyceridemia, Hyperinsulinemia, Type II diabetes mellitus, Increased adipose tissue | ORPHA:71529 | |
Hypertriglyceridemia 1 | Glucose intolerance, Hypertriglyceridemia | OMIM:145750 | |
Mandibuloacral Dysplasia | Loss of subcutaneous adipose tissue in limbs, Hypertriglyceridemia, Lipoatrophy, Increased subcut... | ORPHA:2457 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Osbpl11tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice |
Osbpl11tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Osbpl11tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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