IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|decreased lean body mass||Xxylt1tm1a(EUCOMM)Hmgu||HOM||Early adult||8.24×10-05|
|abnormal vibrissa morphology||Xxylt1tm1a(EUCOMM)Hmgu||HOM||Early adult||2.86×10-07|
|abnormal retina morphology||Xxylt1tm1a(EUCOMM)Hmgu||HOM||Early adult||1.06×10-06|
|increased total body fat amount||Xxylt1tm1a(EUCOMM)Hmgu||HOM||Early adult||4.31×10-05|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Xxylt1 by phenotypic similarity.
|Retinal Dysplasia, Primary||
||Retinal dysplasia, Falciform retinal fold||OMIM:312550|
|Exudative Vitreoretinopathy 7||
||Exudative vitreoretinopathy, Retinal fold, Retinal hole, Retinal degeneration, Retinal detachment||OMIM:617572|
|Retinoschisis 1, X-Linked, Juvenile||
||Retinal pigment epithelial atrophy, Vitreous hemorrhage, Retinal atrophy, Retinal degeneration, M...||OMIM:312700|
|Exudative Vitreoretinopathy 3||
||Exudative vitreoretinopathy, Retinal fold, Retinal hole, Retinal exudate, Retinal detachment||OMIM:605750|
||Macular drusen, Hypoautofluorescent macular lesion, Hyperautofluorescent macular lesion, Macular ...||ORPHA:75376|
|X-Linked Retinal Dysplasia||
||Retinal dysplasia, Abnormality of retinal pigmentation, Abnormal retinal vascular morphology||ORPHA:1852|
||Retinal thinning, Abnormal choroid morphology, Vitritis, Vitreous floaters, Choroidal neovascular...||ORPHA:179|
|Retinitis Pigmentosa 13||
||Rod-cone dystrophy, Optic disc drusen, Asteroid hyalosis, Retinal degeneration, Bone spicule pigm...||OMIM:600059|
|Reese Retinal Dysplasia||
||Retinal dysplasia, Remnants of the hyaloid vascular system||OMIM:266400|
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Xxylt1.
There are 5 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.||G3 (Bethesda, Md.) (June 2020)||Xxylt1tm1a(EUCOMM)Hmgu||PMC7263671|
|High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.||Nature immunology (December 2019)||Xxylt1tm1a(EUCOMM)Hmgu||PMC7338221|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Xxylt1tm1a(EUCOMM)Hmgu||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Xxylt1tm1a(EUCOMM)Hmgu||PMC6459510|
|Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.||Scientific data (September 2017)||Xxylt1tm1a(EUCOMM)Hmgu||PMC5827107|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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|MGI Allele||Allele Type||Produced|
|Xxylt1tm1a(EUCOMM)Hmgu||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Xxylt1tm1e(EUCOMM)Hmgu||Targeted, non-conditional allele||ES Cells|
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