Gene: AW549877

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal retinal inner nuclear layer morphology AW549877tm1b(EUCOMM)Wtsi HOM Early adult 9.25×10-07
abnormal retinal outer nuclear layer morphology AW549877tm1b(EUCOMM)Wtsi HOM   Early adult 2.92×10-08
abnormal retinal blood vessel morphology AW549877tm1b(EUCOMM)Wtsi HOM Early adult 5.20×10-07
increased exploration in new environment AW549877tm1b(EUCOMM)Wtsi HOM Early adult 1.93×10-05
increased cardiac output AW549877tm1b(EUCOMM)Wtsi HOM Early adult 2.19×10-05
increased body temperature AW549877tm1b(EUCOMM)Wtsi HOM   Early adult 4.63×10-05
decreased total retina thickness AW549877tm1b(EUCOMM)Wtsi HOM Early adult 1.28×10-10
decreased startle reflex AW549877tm1b(EUCOMM)Wtsi HOM Early adult 2.59×10-06
increased cardiac stroke volume AW549877tm1b(EUCOMM)Wtsi HOM Early adult 5.85×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/584)  (2/2) N/A
Aorta 2 No  (1/584)  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (4/584)  (2/2) N/A
Brainstem 2 No  (2/584)  (2/2) N/A
Brown adipose tissue 2 No  (2/2)  Wholemount images
Cartilage tissue 2 No  (1/584)  (2/2) N/A
Cecum 1 No  (11/370)  (1/1) N/A
Cerebellum 2 No  (3/584)  (2/2) N/A
Cerebral cortex 2 No  (2/584)  (2/2) N/A
Esophagus 2 No  (7/408)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No  (2/2) N/A
Heart 2 No  (2/584)  (2/2) N/A
Hippocampus 2 No  (3/584)  (2/2) N/A
Hypothalamus 2 No  (2/584)  (2/2) N/A
Kidney 2 No  (21/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/584)  (2/2)  Wholemount images
Lung 2 No  (2/584)  (2/2) N/A
Lymph node 2 No  (1/584) N/A
Mammary gland 2 No  (1/2) N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No  (2/584)  (2/2) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No  (1/562)  (2/2) N/A
Peripheral nervous system 2 No  (2/584)  (2/2) N/A
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/584) N/A
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (1/584)  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (3/584)  (2/2)  Wholemount images
Spleen 2 No  (3/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (3/584)  (2/2) N/A
Testis 2 No  (6/584)  (1/2)  Wholemount images
Thymus 2 No  (1/584)  (1/2)  Wholemount images
Thyroid gland 2 No  (16/584)  (2/2) N/A
Trachea 2 No  (3/584)  (2/2) N/A
Trigeminal V nerve 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vas deferens 2 No  (14/381)  (1/2)  Wholemount images
Vascular system 2 No  (2/2) N/A
White adipose tissue 2 No  (1/2)  Wholemount images
No Embryo expression data was found for this gene.

 Associated Images

Eye Morphology: VIP of left eye
16 Images
Eye Morphology: VIP of right fundus
16 Images
Adult LacZ: LacZ Images Wholemount
9 Images
Eye Morphology: VIP of left fundus
16 Images
Eye Morphology: VIP of right eye
16 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
AW549877tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
AW549877tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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