Gene: Scrib

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo size Scribtm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00
abnormal neural tube closure Scribtm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00
abnormal pericardium morphology Scribtm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00
abnormal midbrain morphology Scribtm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00
prenatal lethality prior to heart atrial septation Scribtm1b(NCOM)Mfgc HOM embryonic day 15.5 0.00
abnormal embryo size Scribtm1b(NCOM)Mfgc HOM embryonic day 15.5 0.00
abnormal hindbrain morphology Scribtm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00
decreased lean body mass Scribtm1b(NCOM)Mfgc HET postnatal 6.21×10-05
abnormal eye morphology Scribtm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00
embryonic growth retardation Scribtm1b(NCOM)Mfgc HOM embryonic day 9.5 0.00
abnormal craniofacial morphology Scribtm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00
abnormal craniofacial morphology Scribtm1b(NCOM)Mfgc HOM embryonic day 15.5 0.00
abnormal embryo size Scribtm1b(NCOM)Mfgc HOM embryonic day 9.5 0.00
preweaning lethality, complete penetrance Scribtm1b(NCOM)Mfgc HOM n/a 0.00
pale yolk sac Scribtm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00
abnormal neural tube closure Scribtm1b(NCOM)Mfgc HOM embryonic day 9.5 0.00
short tibia Scribtm1b(NCOM)Mfgc HET postnatal 7.15×10-05
abnormal placenta size Scribtm1b(NCOM)Mfgc HOM embryonic day 12.5 0.00

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 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 2  (6/485)  (2/3) N/A
Central nervous system ganglion 2  (1/51)  (2/2) N/A
Ear 2  (1/485)  (2/3) N/A
Embryo 2  (1/485)  (2/3) N/A
Eye 2  (1/485)  (2/3) N/A
Foot 2  (1/485)  (2/3) N/A
Forebrain 2  (1/485)  (2/3) N/A
Forelimb 2  (1/485)  (2/3) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 2  (1/485)  (2/3) N/A
Head 2  (5/485)  (2/3) N/A
Heart 2  (1/485)  (2/3) N/A
Hindbrain 2  (6/485)  (2/3) N/A
Hindlimb 2  (1/485)  (2/3) N/A
Liver 2  (1/485)  (2/3) N/A
Lung 2  (1/485)  (2/3) N/A
Mandibular process 2  (1/485)  (2/3) N/A
Maxillary process 2  (1/485)  (2/3) N/A
Midbrain 2  (1/485)  (2/3) N/A
Nose 2  (1/51)  (2/2) N/A
Oral cavity 2  (1/485)  (2/3) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 2  (1/485)  (2/3) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Tail 2  (1/485)  (2/3) N/A
Tail somite 2  (1/485)  (2/3) N/A
Trachea 2  (1/50)  (2/2) N/A
Urinary system 2  (1/50)  (2/2) N/A

 Associated Images

Eye Morphology: Images Ophthalmoscopy
13 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Gross Morphology Embryo E9.5
6 Images
Histopathology
3 Images
X-ray: XRay Images Dorso Ventral
10 Images
Gross Morphology Embryo E14.5-E15.5
4 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Gross Pathology and Tissue Collection
8 Images
X-ray: XRay Images Lateral Orientation
10 Images
Combined SHIRPA and Dysmorphology
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Scribtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Scribtm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Scribtm1b(NCOM)Mfgc Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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