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Gene: Exoc5 MGI:2145645

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
exocyst complex component 5
Synonyms:
PRO1912,  SEC10,  Sec10l1

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Exoc5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Exoc5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Exoc5.

There are 10 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Conditional Loss of the Exocyst Component Exoc5 in Retinal Pigment Epithelium (RPE) Results in RPE Dysfunction, Photoreceptor Cell Degeneration, and Decreased Visual Function. International journal of molecular sciences (May 2021) Exoc5tm1c(KOMP)Mbp PMC8151988
Disrupted glucose homeostasis and skeletal muscle-specific glucose uptake in an exocyst knockout mouse model. The Journal of biological chemistry (February 2021) Exoc5tm1c(KOMP)Mbp PMC8027262
Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content. The Journal of biological chemistry (November 2019) Exoc5tm1c(KOMP)Mbp PMC6916495
Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis. Circulation (August 2019) Exoc5tm1c(KOMP)Mbp PMC6989054
Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing. Molecular neurobiology (January 2018) Exoc5tm1c(KOMP)Mbp PMC6984595
The exocyst is required for photoreceptor ciliogenesis and retinal development. The Journal of biological chemistry (July 2017) Exoc5tm1c(KOMP)Mbp PMC5592663
Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy. Scientific reports (August 2016) Exoc5tm1c(KOMP)Mbp PMC4980620
Arl13b and the exocyst interact synergistically in ciliogenesis. Molecular biology of the cell (November 2015) Exoc5tm1c(KOMP)Mbp PMC4713133
Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions. PloS one (June 2015) Exoc5tm1c(KOMP)Mbp Exoc5tm1a(KOMP)Mbp PMC4457632
The exocyst gene Sec10 regulates renal epithelial monolayer homeostasis and apoptotic sensitivity. American journal of physiology. Cell physiology (June 2015) Exoc5tm1a(KOMP)Mbp PMC4525081

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Exoc5tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Exoc5tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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