Gene Summary

Name:
exportin 1
Synonyms:
Crm1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
prenatal lethality prior to heart atrial septation Xpo1em1(IMPC)Mbp HOM   E15.5 0.00
preweaning lethality, complete penetrance Xpo1em1(IMPC)Mbp HOM   Early adult 0.00
embryonic lethality prior to organogenesis Xpo1em1(IMPC)Mbp HOM   E9.5 0.00
increased heart weight Xpo1em1(IMPC)Mbp HET Early adult 2.63×10-12

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Histopathology

Images

205 Images

Human diseases caused by Xpo1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Xpo1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Ethanolaminosis
Cardiomegaly OMIM:227150
Congenital Tricuspid Valve Dysplasia
Right atrial enlargement, Abnormal tricuspid valve leaflet morphology, Patent foramen ovale, Abno... ORPHA:555874

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Testes - tissue specific degenerative process Xpo1em1(IMPC)Mbp HET Early adult
Liver - organ specific developmental defect Xpo1em1(IMPC)Mbp HET Early adult
Testes - atrophy Xpo1em1(IMPC)Mbp HET Early adult
Liver - developmental and structural abnormality Xpo1em1(IMPC)Mbp HET Early adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Xpo1.

No publications found that use IMPC mice or data for Xpo1.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Xpo1em1(IMPC)Mbp Exon Deletion Mice, Tissue
Xpo1tm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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