The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Slc6a20a by orthology or direct annotation.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc6a20a.
There are 2 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes.||Frontiers in molecular neuroscience (March 2022)||Slc6a20atm1b(KOMP)Wtsi||PMC8936588|
|SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.||EMBO molecular medicine (January 2021)||Slc6a20atm1b(KOMP)Wtsi||PMC7863395|
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|MGI Allele||Allele Type||Produced|
|Slc6a20atm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Slc6a20atm2a(KOMP)Mbp||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Slc6a20atm2e(KOMP)Mbp||Targeted, non-conditional allele||ES Cells|
|Slc6a20atm1a(KOMP)Mbp||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Slc6a20atm1b(KOMP)Wtsi||Reporter-tagged deletion allele (with selection cassette)||Mice|
|Slc6a20atm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
|Slc6a20atm1e(KOMP)Mbp||Targeted, non-conditional allele||ES Cells|