Gene Summary

Name:
solute carrier family 6 (neurotransmitter transporter), member 20A
Synonyms:
A730081N20Rik,  Xtrp3s1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Electrocardiogram (ECG)

Waveform Image

34 Images

Immunophenotyping

Panel A FCS file(s)

6 Images

Immunophenotyping

Panel B FCS file(s)

6 Images

Human diseases caused by Slc6a20a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Slc6a20a by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Iminoglycinuria
OMIM:242600
Iminoglycinuria
ORPHA:42062
Hyperglycinuria
OMIM:138500

The table below shows human diseases predicted to be associated to Slc6a20a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Iminoglycinuria
OMIM:242600
Iminoglycinuria
ORPHA:42062
Hyperglycinuria
OMIM:138500

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Slc6a20a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc6a20a.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes. Frontiers in molecular neuroscience (March 2022) Slc6a20atm1b(KOMP)Wtsi PMC8936588
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. EMBO molecular medicine (January 2021) Slc6a20atm1b(KOMP)Wtsi PMC7863395

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MGI Allele Allele Type Produced
Slc6a20atm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Slc6a20atm2a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Slc6a20atm2e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Slc6a20atm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Slc6a20atm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Slc6a20atm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Slc6a20atm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells

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