Gene: Tmem189

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Tmem189tm1a(KOMP)Wtsi HOM Early adult 2.67×10-12
decreased hemoglobin content Tmem189tm1a(KOMP)Wtsi HOM Early adult 2.01×10-11
impaired glucose tolerance Tmem189tm1a(KOMP)Wtsi HOM Early adult 1.85×10-05
abnormal bone structure Tmem189tm1a(KOMP)Wtsi HOM Early adult 9.47×10-11
increased circulating magnesium level Tmem189tm1a(KOMP)Wtsi HOM Early adult 2.90×10-05
absent pinna reflex Tmem189tm1a(KOMP)Wtsi HOM Early adult 9.36×10-05
increased mean corpuscular volume Tmem189tm1a(KOMP)Wtsi HOM Early adult 2.46×10-06
decreased grip strength Tmem189tm1a(KOMP)Wtsi HOM Early adult 6.55×10-05
decreased erythrocyte cell number Tmem189tm1a(KOMP)Wtsi HOM Early adult 9.18×10-13
increased circulating potassium level Tmem189tm1a(KOMP)Wtsi HOM Early adult 7.13×10-05
decreased circulating total protein level Tmem189tm1a(KOMP)Wtsi HOM Early adult 5.32×10-08
decreased CD4-positive, alpha beta T cell number Tmem189tm1a(KOMP)Wtsi HOM Early adult 2.13×10-10
increased B cell number Tmem189tm1a(KOMP)Wtsi HOM Early adult 1.43×10-05
increased mean platelet volume Tmem189tm1a(KOMP)Wtsi HOM Early adult 5.79×10-11
decreased lean body mass Tmem189tm1a(KOMP)Wtsi HOM Early adult 1.12×10-12
decreased circulating calcium level Tmem189tm1a(KOMP)Wtsi HOM Early adult 7.55×10-10
abnormal incisor color Tmem189tm1a(KOMP)Wtsi HOM Early adult 2.40×10-07
decreased hematocrit Tmem189tm1a(KOMP)Wtsi HOM Early adult 4.56×10-11
decreased total body fat amount Tmem189tm1a(KOMP)Wtsi HOM Early adult 1.86×10-06
decreased T cell number Tmem189tm1a(KOMP)Wtsi HOM Early adult 2.53×10-14
decreased CD8-positive, alpha-beta T cell number Tmem189tm1a(KOMP)Wtsi HOM Early adult 1.17×10-12
decreased bone mineral content Tmem189tm1a(KOMP)Wtsi HOM Early adult 6.75×10-13
decreased circulating thyroxine level Tmem189tm1a(KOMP)Wtsi HOM Early adult 2.06×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No  (1/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Section Images

View all 16 images

View all 8 images

View all 7 images

No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Forepaw
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
27 Images
X-ray: XRay Images Whole Body Dorso Ventral
38 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
X-ray: XRay Images Skull Lateral Orientation
13 Images
Legacy Phenotype Associated Images

View all 125 images

View all 21 images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Tmem189tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Tmem189tm35635(L1L2_Pgk_P) Targeting vectors
Tmem189tm361668(L1L2_Bact_P) Targeting vectors

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