Arhgef18 | Rho/Rac guanine nucleotide exchange factor 18

GeneMGI:2142567Synonyms: A430078G23Rik, D030053O22Rik

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Mortality/aging

17 No significant impact

4 Not tested

Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
42Embryo tissues

Phenotypes

abnormal retina morphology1 supporting datasetArhgef18tm1b(KOMP)MbpheterozygoteEarly adult1.15x10-16 
preweaning lethality, complete penetrance1 supporting datasetArhgef18tm1b(KOMP)MbphomozygoteEarly adultN/A * 
increased circulating amylase level1 supporting datasetArhgef18tm1b(KOMP)MbpheterozygoteEarly adult8.26x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetArhgef18Gt(EUC0027g03)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Arhgef18tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Arhgef18tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Arhgef18tm1b(KOMP)MbpReporter-tagged deletion allele (with selection cassette)mouse
Arhgef18tm1e(KOMP)MbpTargeted, non-conditional alleleES Cell
Arhgef18tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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