Gene Summary

Name:
indoleamine 2,3-dioxygenase 2
Synonyms:
Ido2,  C230043N17Rik,  Indol1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

13 Images

X-ray

XRay Images Whole Body Dorso Ventral

14 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

15 Images

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

X-ray

XRay Images Forepaw

14 Images

Histopathology

Images

4 Images

Legacy Phenotype Associated Images

View all 85 images

Human diseases caused by Ido2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ido2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Retinal Telangiectasia And Hypogammaglobulinemia
Reduced delayed hypersensitivity, Decreased circulating IgG level OMIM:267900
Monocyte Chemotactic Disorder
Cutaneous anergy, Chronic mucocutaneous candidiasis OMIM:252250
Immunodeficiency 24
Decreased circulating IgG2 level, Partial absence of specific antibody response to tetanus vaccin... OMIM:615897
Caspase 8 Deficiency
Decreased circulating total IgM, Complete or near-complete absence of specific antibody response ... OMIM:607271
Candidiasis, Familial, 1
Cutaneous anergy, Chronic mucocutaneous candidiasis OMIM:114580
Immunodeficiency, X-Linked, With Deficiency Of 115,000 Dalton Surface Glycoprotein
Abnormality of T cell physiology OMIM:308220
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Immunodeficiency 11
Reduced antigen-specific T cell proliferation, Decreased circulating antibody level, Agammaglobul... OMIM:615206
Adult Acute Respiratory Distress Syndrome
Abnormality of tumor necrosis factor secretion, Increased circulating interleukin 6 concentration... ORPHA:70578
Acute Lung Injury
Abnormality of tumor necrosis factor secretion, Increased circulating interleukin 6 concentration... ORPHA:178320
Immunodeficiency, Common Variable, 2
Decreased circulating IgA level, Impaired T cell function, Recurrent otitis media, Recurrent pneu... OMIM:240500
Immunodeficiency, Common Variable, 1
Decreased circulating total IgM, Decreased circulating IgA level, Impaired T cell function, Recur... OMIM:607594
Familial Hemophagocytic Lymphohistiocytosis
Abnormality of tumor necrosis factor secretion, Increased circulating interferon-gamma concentrat... ORPHA:540
Macrophage Activation Syndrome
Increased circulating interferon-gamma concentration, Abnormality of tumor necrosis factor secret... ORPHA:158061
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Increased circulating IgE level, Increased circulating IgM level, Reduced antigen-specific T cell... OMIM:617241
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Decreased specific anti-polysaccharide antibody level, Decreased CD69 upregulation upon TCR activ... OMIM:300853
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Inflammatory abnormality of the skin, Increased circulating IgE level, Recurrent otitis media, Re... ORPHA:277
Infection-Related Hemolytic Uremic Syndrome
Myocarditis, Increased circulating interleukin 6 concentration, Acute colitis, Pancreatitis, Sept... ORPHA:544482
Reticular Dysgenesis
Lack of T cell function, Impaired T cell function OMIM:267500
Sweet Syndrome
Abnormality of tumor necrosis factor secretion, Acne inversa, Predominantly dermal neutrophilic i... ORPHA:3243
Immunodeficiency With Hyper-Igm, Type 1
Impaired Ig class switch recombination, Increased circulating IgA level, Stomatitis, Chronic hepa... OMIM:308230
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells
Cutaneous anergy OMIM:183350
Psoriasis-Related Juvenile Idiopathic Arthritis
Abnormality of tumor necrosis factor secretion, Malar rash, Oligoarthritis, Enthesitis, Skin rash... ORPHA:85436
Immunodeficiency 96
Decreased circulating total IgM, Decreased circulating IgA level, Recurrent otitis media, Decreas... OMIM:619774
Autoimmune Lymphoproliferative Syndrome
Increased circulating IgA level, Increased circulating IgM level, Reduced delayed hypersensitivit... OMIM:601859
Bare Lymphocyte Syndrome, Type Ii
Cholangitis, Cutaneous anergy, Colitis, Infectious encephalitis, Panhypogammaglobulinemia, Agamma... OMIM:209920
Immunodeficiency By Defective Expression Of Mhc Class Ii
Acute otitis media, Skin rash, Rhinitis, Decreased circulating antibody level, Sinusitis, Panhypo... ORPHA:572
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Abnormality of B cell physiology, Cutaneous anergy, Decreased lymphocyte proliferation in respons... OMIM:600802
Car T Cell Therapy-Associated Cytokine Release Syndrome
Increased circulating interferon-gamma concentration, Increased circulating interleukin 6 concent... ORPHA:542323
Roifman Syndrome
Eczema, Recurrent otitis media, Recurrent pneumonia, Decreased circulating antibody level, Decrea... ORPHA:353298
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Acute otitis media, Decreased circulating total IgM, Skin rash, Partial IgA deficiency, Chronic o... ORPHA:35078
Immunodeficiency 58
Chronic otitis media, Recurrent cutaneous abscess formation, Decreased specific antibody response... OMIM:618131
Autoimmune Lymphoproliferative Syndrome, Type Iia
Increased circulating IgA level, Malar rash, Increased circulating IgM level, Reduced delayed hyp... OMIM:603909
Congenital Disorder Of Glycosylation, Type Iil
Inflammation of the large intestine, Decreased specific anti-polysaccharide antibody level, Impai... OMIM:614576
Aregenerative Anemia
Bone marrow hypocellularity, Abnormality of interleukin secretion ORPHA:101096
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Increased circulating IgE level, Increased circulating IgG level, Perianal abscess, Pancolitis, E... OMIM:618213
T-Cell Immunodeficiency With Thymic Aplasia
Eczematoid dermatitis, Reduced delayed hypersensitivity, Recurrent pneumonia, Bronchiectasis, Pyo... OMIM:242700
Purine Nucleoside Phosphorylase Deficiency
Abnormality of B cell physiology, Impaired T cell function, Sinusitis, Pneumonia, Decreased lymph... OMIM:613179
Wiskott-Aldrich Syndrome
Increased circulating IgA level, Decreased circulating total IgM, Inflammation of the large intes... OMIM:301000
T-Cell Immunodeficiency With Thymic Aplasia
Chronic otitis media, Eczematoid dermatitis, Atypical or prolonged hepatitis, Oligoclonal T cell ... ORPHA:83471
Schimke Immuno-Osseous Dysplasia
Pancreatitis, Bone marrow hypocellularity, Impaired T cell function, Abnormal lymphocyte physiolo... ORPHA:1830
Sarcoidosis, Susceptibility To, 1
Inflammation of the large intestine, Increased circulating antibody level, Uveitis, Arthritis, Ir... OMIM:181000
Parenteral Nutrition-Associated Cholestasis
Abnormality of cytokine secretion ORPHA:567983
Acrodermatitis Enteropathica, Zinc-Deficiency Type
Impaired T cell function OMIM:201100
Orotic Aciduria
Impaired T cell function OMIM:258900
Hereditary Orotic Aciduria
Impaired T cell function ORPHA:30
Velocardiofacial Syndrome
Impaired T cell function OMIM:192430
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Psoriasiform dermatitis, Abnormality of T cell physiology ORPHA:2237
Progeroid Short Stature With Pigmented Nevi
Allergic conjunctivitis, Allergic rhinitis, Impaired T cell function OMIM:176690
22Q11.2 Deletion Syndrome
Chronic otitis media, Impaired T cell function, Arthritis, Acne, Seborrheic dermatitis ORPHA:567
Digeorge Syndrome
Impaired T cell function, Acne, Seborrheic dermatitis, Recurrent pneumonia, Recurrent otitis medi... OMIM:188400

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Thyroid - process of degenerative change Ido2tm3a(EUCOMM)Wtsi HOM Early adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ido2.

There are 6 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Absence of indoleamine 2,3‑dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice. Molecular medicine reports (December 2022) Ido2tm1a(KOMP)Wtsi PMC9813552
Indoleamine 2,3-Dioxygenase 2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation. International journal of molecular sciences (August 2020) Ido2tm1a(KOMP)Wtsi PMC7432009
Indoleamine-2,3-dioxygenase-1 is a molecular target for the protective activity of mood stabilizers against mania-like behavior induced by d-amphetamine. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (November 2019) Ido2tm3a(EUCOMM)Wtsi 31760073
Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma. Cancer science (September 2019) Ido2tm3a(EUCOMM)Wtsi PMC6778659
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Ido2tm3a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Ido2tm3a(EUCOMM)Wtsi PMC6459510

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ido2tm3a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ido2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ido2tm3e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter