Gene Summary

Name:
U6 snRNA biogenesis 1
Synonyms:
AA960436

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Usb1em1(IMPC)Bay HOM   E12.5 0.00
preweaning lethality, complete penetrance Usb1em1(IMPC)Bay HOM   Early adult 0.00
edema Usb1em1(IMPC)Bay HOM E9.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

MicroCT E9.5

Embryo reconstruction

6 Images

Eye Morphology

VIP of left eye

15 Images

Eye Morphology

VIP of right eye

15 Images

Eye Morphology

VIP of right fundus

15 Images

Eye Morphology

VIP of left fundus

15 Images

Human diseases caused by Usb1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Usb1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Poikiloderma With Neutropenia
Edema OMIM:604173
Dyskeratosis Congenita
ORPHA:1775

The table below shows human diseases predicted to be associated to Usb1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Lipedema
Edema OMIM:614103
Angioedema, Hereditary, 6
Facial edema, Edema of the dorsum of hands, Angioedema OMIM:619363
Kaposi Sarcoma, Susceptibility To
Edema OMIM:148000
Lymphatic Malformation 11
Pedal edema, Lymphedema OMIM:619401
Lymphatic Malformation 8
Generalized edema, Pleural effusion, Nonimmune hydrops fetalis, Stillbirth, Polyhydramnios, Peric... OMIM:618773
Edema, Familial Idiopathic, Prepubertal
Edema OMIM:129840
Lymphatic Malformation 14
Lymphedema OMIM:620602
Lymphatic Malformation 2
Lymphedema OMIM:611944
Macular Dystrophy, Dominant Cystoid
Edema, Cystoid macular edema OMIM:153880
Pulmonary Edema Of Mountaineers, Susceptibility To
Pulmonary edema, Edema OMIM:178400
Idiopathic Steroid-Sensitive Nephrotic Syndrome
Lymphedema ORPHA:69061
White Sponge Nevus 2
Edema OMIM:615785
Lymphatic Malformation 7
Facial edema, Chylothorax, Lymphedema, Ascites, Increased nuchal translucency, Pleural effusion, ... OMIM:617300
Lymphangiectasia, Intestinal
Pedal edema, Edema, Stillbirth OMIM:152800
Lymphatic Malformation 10
Lymphedema OMIM:619369
Lymphangiectasia, Pulmonary, Congenital
Facial edema, Chylothorax, Edema, Lymphedema, Ascites, Pleural effusion, Nonimmune hydrops fetali... OMIM:265300
Deafness, Unilateral, With Delayed Endolymphatic Hydrops
Edema OMIM:612097
Corneal Dystrophy, Fuchs Endothelial, 2
Edema OMIM:610158
Poikiloderma With Neutropenia
Edema OMIM:604173
Dyskeratosis Congenita
ORPHA:1775

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Usb1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Usb1.

No publications found that use IMPC mice or data for Usb1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Usb1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Usb1em1(IMPC)Bay Exon Deletion Mice
Usb1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Usb1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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