banner
Genes Phenotypes Help, News, Blog

Gene: Atf5 MGI:2141857

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
activating transcription factor 5
Synonyms:
ODA-10,  AFTA,  Atfx,  Atf7

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Atf5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Atf5 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia
Neonatal death, Anteverted nares, Underdeveloped nasal alae OMIM:612138
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Hernia, Anterior Diaphragmatic
Neonatal death OMIM:306950
Boomerang Dysplasia
Neonatal death, Hypoplastic nasal septum, Wide nasal bridge, Underdeveloped nasal alae OMIM:112310
Asthma, Nasal Polyps, And Aspirin Intolerance
Nasal polyposis OMIM:208550
Ciliary Dyskinesia With Defective Radial Spokes
Nasal polyposis, Absent respiratory ciliary axoneme radial spokes, Chronic rhinitis OMIM:242670
Ciliary Dyskinesia, Primary, 42
Recurrent sinusitis, Nasal polyposis, Chronic rhinitis OMIM:618695
Abcd Syndrome
Aganglionic megacolon, Abnormal auditory evoked potentials, Large for gestational age, Total inte... OMIM:600501
Ciliary Dyskinesia, Primary, 19
Rhinitis, Nasal polyposis, Recurrent sinusitis, Absent inner and outer dynein arms OMIM:614935
Pai Syndrome
Nasal polyposis, Depressed nasal bridge, Midline defect of the nose ORPHA:1993
Immunodeficiency 13
Recurrent sinusitis, Nasal polyposis, Recurrent upper respiratory tract infections OMIM:615518
Cleft, Median, Of Upper Lip With Polyps Of Facial Skin And Nasal Mucosa
Nasal polyposis OMIM:155145
Ciliary Dyskinesia, Primary, 35
Nasal polyposis, Chronic rhinitis OMIM:617092
Ciliary Dyskinesia, Primary, 49, Without Situs Inversus
Nasal polyposis, Recurrent sinusitis OMIM:620197
Bare Lymphocyte Syndrome, Type I
Nasal polyposis OMIM:604571
Ciliary Dyskinesia, Primary, 22
Nasal polyposis, Rhinitis, Recurrent sinusitis, Absent inner and outer dynein arms OMIM:615444
Lipoid Proteinosis
Nasal polyposis, Dysphagia ORPHA:530
Ciliary Dyskinesia, Primary, 30
Nasal congestion, Absent outer dynein arms, Nasal polyposis OMIM:616037
Ciliary Dyskinesia, Primary, 2
Nasal polyposis, Absent inner and outer dynein arms OMIM:606763
Ciliary Dyskinesia, Primary, 5
Recurrent sinusitis, Nasal polyposis, Chronic rhinitis OMIM:608647
Ciliary Dyskinesia, Primary, 15
Abnormal axonemal organization of respiratory motile cilia, Nasal polyposis OMIM:613808
Ciliary Dyskinesia, Primary, 1
Absent outer dynein arms, Nasal polyposis, Anosmia, Chronic rhinitis OMIM:244400
Eosinophilic Granulomatosis With Polyangiitis
Weight loss, Nasal polyposis, Dysphagia ORPHA:183
Peutz-Jeghers Syndrome
Neoplasm of the nose, Nasal polyposis, Abnormality of the nose ORPHA:2869
Primary Ciliary Dyskinesia
Nasal congestion, Nasal polyposis, Chronic rhinitis ORPHA:244
Granulomatosis With Polyangiitis
Concave nasal ridge, Nasal mucosa vasculitis, Weight loss OMIM:608710
Benign Schwannoma
Nasal polyposis, Facial palsy, Abnormality of the twelfth cranial nerve, Vestibular schwannoma, A... ORPHA:252164
Peutz-Jeghers Syndrome
Nasal polyposis OMIM:175200
Cystic Fibrosis
Failure to thrive, Nasal polyposis, Decreased body mass index ORPHA:586
Cystic Fibrosis
Failure to thrive, Nasal polyposis OMIM:219700
Sarcoidosis
Abnormal nasal mucosa morphology, Facial palsy, Weight loss ORPHA:797

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Atf5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Atf5.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
ATF5 is a regulator of exercise-induced mitochondrial quality control in skeletal muscle. Molecular metabolism (November 2022) Atf5tm1(KOMP)Vlcg PMC9661517
Cardioprotection by the mitochondrial unfolded protein response requires ATF5. American journal of physiology. Heart and circulatory physiology (July 2019) Atf5tm1(KOMP)Vlcg 31274354
Co-opting the unfolded protein response to elicit olfactory receptor feedback. Cell (October 2013) Atf5tm1(KOMP)Vlcg PMC3843319

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Atf5tm3e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Atf5tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Atf5tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Atf5tm3a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Atf5tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter