Depdc5 | DEP domain containing 5

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Mortality/aging

16 No significant impact

5 Not tested

Gene metrics:4Significant phenotypes
5Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

increased circulating alkaline phosphatase level1 supporting datasetDepdc5tm1b(EUCOMM)HmguheterozygoteEarly adult2.76x10-15 
preweaning lethality, complete penetrance1 supporting datasetDepdc5tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased total body fat amount1 supporting datasetDepdc5tm1b(EUCOMM)HmguheterozygoteEarly adult9.11x10-5 
impaired glucose tolerance1 supporting datasetDepdc5tm1b(EUCOMM)HmguheterozygoteEarly adult9.88x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Depdc5tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Depdc5tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Depdc5tm1c(EUCOMM)HmguWild type floxed exon (post-Flp)mouse
Depdc5tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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