Depdc5 | DEP domain containing 5
GeneMGI:2141101
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Mortality/aging
16 No significant impact
5 Not tested
Gene metrics:4Significant phenotypes
5Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
increased circulating alkaline phosphatase level | 1 supporting dataset | Depdc5tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.76x10-15 | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Depdc5tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
increased total body fat amount | 1 supporting dataset | Depdc5tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.11x10-5 | ||
impaired glucose tolerance | 1 supporting dataset | Depdc5tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.88x10-6 |
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External links
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Depdc5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Depdc5tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Depdc5tm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | | mouse |
Depdc5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |