Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
increased circulating alkaline phosphatase level | Depdc5tm1b(EUCOMM)Hmgu | HET | Early adult | 6.88×10-13 | ||
preweaning lethality, complete penetrance | Depdc5tm1b(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
impaired glucose tolerance | Depdc5tm1b(EUCOMM)Hmgu | HET | Early adult | 1.58×10-05 |
Gene: Depdc5
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IMPC lacZ Expression Data
Anatomy | #HET Specimens | HOM Images? | WT Expr | Mutant Expr | Images |
---|---|---|---|---|---|
Adrenal gland | 2 | No | (3/590) | N/A | |
Aorta | 2 | No | (1/590) | N/A | |
Bone | 2 | No | N/A | ||
Brain | 2 | No | (3/590) | N/A | |
Brainstem | 2 | No | (2/590) | N/A | |
Brown adipose tissue | 2 | No | N/A | ||
Cartilage tissue | 2 | No | N/A | ||
Cerebellum | 2 | No | (3/590) | N/A | |
Cerebral cortex | 2 | No | (2/590) | N/A | |
Esophagus | 2 | No | (7/415) | N/A | |
Eye | 2 | No | N/A | ||
Gall bladder | 2 | No | N/A | ||
Heart | 2 | No | (1/590) | N/A | |
Hippocampus | 2 | No | (3/590) | N/A | |
Hypothalamus | 2 | No | (2/590) | N/A | |
Kidney | 2 | No | (20/590) | (2/2) | Wholemount images |
Large intestine | 2 | No | (10/590) | N/A | |
Liver | 2 | No | N/A | ||
Lower urinary tract | 2 | No | (1/590) | N/A | |
Lung | 2 | No | (1/590) | N/A | |
Lymph node | 2 | No | N/A | ||
Mammary gland | 2 | No | N/A | ||
Olfactory lobe | 2 | No | (2/590) | N/A | |
Oral epithelium | 2 | No | N/A | ||
Ovary | 2 | No | (1/590) | N/A | |
Oviduct | 2 | No | N/A | ||
Pancreas | 2 | No | (5/590) | N/A | |
Parathyroid gland | 2 | No | N/A | ||
Peripheral nervous system | 2 | No | (1/590) | (2/2) | Wholemount images |
Peyer's patch | 2 | No | N/A | ||
Pituitary gland | 2 | No | (1/590) | N/A | |
Prostate gland | 2 | No | (12/590) | (1/2) | Wholemount images |
Skeletal muscle | 2 | No | N/A | ||
Skin | 2 | No | N/A | ||
Small intestine | 2 | No | (9/590) | N/A | |
Spinal cord | 2 | No | (2/590) | N/A | |
Spleen | 2 | No | (2/590) | N/A | |
Stomach | 2 | No | (13/590) | N/A | |
Striatum | 2 | No | (3/590) | N/A | |
Testis | 2 | No | (5/590) | (1/2) | Wholemount images |
Thymus | 2 | No | N/A | ||
Thyroid gland | 2 | No | (16/590) | N/A | |
Trachea | 2 | No | (2/590) | N/A | |
Uterus | 2 | No | N/A | ||
Vascular system | 2 | No | N/A | ||
White adipose tissue | 2 | No | N/A |
LacZ Wholemount Images
LacZ Section Images
Anatomy | #HET Specimens | WT Expr | Mutant Expr | Images |
---|---|---|---|---|
Brain | 2 | (6/506) | (2/4) | N/A |
Ear | 2 | (1/506) | N/A | |
Embryo | 2 | (1/507) | (2/4) | N/A |
Eye | 2 | (1/506) | (2/4) | N/A |
Foot | 2 | (1/506) | (1/4) | N/A |
Forebrain | 2 | (1/506) | (2/4) | N/A |
Forelimb | 2 | (1/506) | (1/4) | N/A |
Hand | 2 | (1/506) | N/A | |
Head | 2 | (5/506) | (2/4) | N/A |
Heart | 2 | (1/506) | (1/4) | N/A |
Hindbrain | 2 | (6/506) | (2/4) | N/A |
Hindlimb | 2 | (1/506) | (2/4) | N/A |
Liver | 2 | (1/504) | N/A | |
Lung | 2 | (1/504) | N/A | |
Mandibular process | 2 | (1/506) | N/A | |
Maxillary process | 2 | (1/506) | N/A | |
Midbrain | 2 | (1/506) | (2/4) | N/A |
Oral cavity | 2 | (1/504) | N/A | |
Skin | 2 | (1/506) | (2/4) | N/A |
Tail | 2 | (1/506) | (2/4) | N/A |
Tail somite | 2 | (1/506) | (2/4) | N/A |
Associated Images
Disease Models
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MGI Allele | Allele Type | Produced |
---|---|---|
Depdc5tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (post-Cre) | Mice |
Depdc5tm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | Mice |
Depdc5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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