The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Mapre3 by phenotypic similarity.
||Hyposegmentation of neutrophil nuclei, Leukopenia||OMIM:310350|
|Pancytopenia And Occlusive Vascular Disease||
||Thrombocytopenia, Leukopenia, Pancytopenia, Anemia||OMIM:167850|
||Congenital agranulocytosis, Lymphopenia, Leukopenia, Hypoplasia of the thymus||OMIM:267500|
|Neutropenia, Severe Congenital, 5, Autosomal Recessive||
||Extramedullary hematopoiesis, Neutropenia, Thrombocytopenia, Leukopenia, Splenomegaly, Anemia||OMIM:615285|
|Acute Erythroid Leukemia||
||Pancytopenia, Erythroid hypoplasia, Leukopenia, Anemia||ORPHA:318|
|Bone Marrow Failure Syndrome 2||
||Thrombocytopenia, Anemia, Leukopenia||OMIM:615715|
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mapre3.
There are 1 publication which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca(2+) Signaling in Endothelial Cells.||Cell reports (June 2015)||Mapre3tm1c(EUCOMM)Wtsi Mapre3tm1a(EUCOMM)Wtsi||PMC4487770|
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|MGI Allele||Allele Type||Produced|
|Mapre3tm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||Targeting vectors, ES Cells|
|Mapre3tm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|