Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

solute carrier family 15, member 4
PTR4,  C130069N12Rik,  PHT1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Slc15a4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Slc15a4 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Acute Lung Injury
Abnormality of serum cytokine level, Increased circulating surfactant protein level, Increased ci... ORPHA:178320
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6, Pneumonia, Pancreatitis, Abnormal serum interleukin level, A... ORPHA:70578
Macrophage Activation Syndrome
Increased circulating interleukin 6, Hepatitis, Increased inflammatory response, Increased circul... ORPHA:158061
Familial Hemophagocytic Lymphohistiocytosis
Abnormality of serum cytokine level, Increased circulating interleukin 6, Erythroderma, Infectiou... ORPHA:540
Sweet Syndrome
Increased circulating interleukin 6, Inflammation of the large intestine, Predominantly dermal ne... ORPHA:3243
Car T Cell Therapy-Associated Cytokine Release Syndrome
Abnormality of serum cytokine level, Increased circulating interleukin 6, Vomiting, Nausea, Eleva... ORPHA:542323
Psoriasis-Related Juvenile Idiopathic Arthritis
Psoriasiform dermatitis, Oligoarthritis, Sacroiliac arthritis, Anterior uveitis, Iridocyclitis, U... ORPHA:85436
Ectodermal Dysplasia And Immunodeficiency 2
Defective production of NFKB1-dependent cytokines OMIM:612132
Parenteral Nutrition-Associated Cholestasis
Abnormal circulating fatty-acid concentration, Conjugated hyperbilirubinemia, Abnormality of cyto... ORPHA:567983
Aregenerative Anemia
Abnormality of interleukin secretion ORPHA:101096
Infection-Related Hemolytic Uremic Syndrome
Hyperkalemia, Hyponatremia, Myocarditis, Increased circulating interleukin 6, Bloody diarrhea, Vo... ORPHA:544482


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Slc15a4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc15a4.

No publications found that use IMPC mice or data for Slc15a4.

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MGI Allele Allele Type Produced
Slc15a4tm463545(L1L2_GT2_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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