Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

solute carrier family 15, member 4
PTR4,  C130069N12Rik,  PHT1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Slc15a4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Slc15a4 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Acute Lung Injury
Increased circulating interleukin 6 concentration, Abnormality of tumor necrosis factor secretion... ORPHA:178320
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6 concentration, Abnormality of tumor necrosis factor secretion... ORPHA:70578
Macrophage Activation Syndrome
Increased circulating interleukin 6 concentration, Abnormality of tumor necrosis factor secretion... ORPHA:158061
Familial Hemophagocytic Lymphohistiocytosis
Maculopapular exanthema, Increased circulating interleukin 6 concentration, Abnormality of tumor ... ORPHA:540
Sweet Syndrome
Oligoarthritis, Increased circulating interleukin 6 concentration, Abnormality of tumor necrosis ... ORPHA:3243
Car T Cell Therapy-Associated Cytokine Release Syndrome
Vomiting, Increased circulating interleukin 6 concentration, Diarrhea, Abnormality of serum cytok... ORPHA:542323
Psoriasis-Related Juvenile Idiopathic Arthritis
Sacroiliac arthritis, Malar rash, Oligoarthritis, Abnormality of tumor necrosis factor secretion,... ORPHA:85436
Parenteral Nutrition-Associated Cholestasis
Abnormality of cytokine secretion, Hyperlipidemia, Abnormal circulating fatty-acid concentration,... ORPHA:567983
Aregenerative Anemia
Abnormality of interleukin secretion ORPHA:101096
Infection-Related Hemolytic Uremic Syndrome
Septic arthritis, Bloody diarrhea, Vomiting, Myocarditis, Increased circulating interleukin 6 con... ORPHA:544482
Ectodermal Dysplasia And Immunodeficiency 2
Defective production of NFKB1-dependent cytokines, Chronic diarrhea OMIM:612132


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Slc15a4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc15a4.

No publications found that use IMPC mice or data for Slc15a4.

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MGI Allele Allele Type Produced
Slc15a4tm463545(L1L2_GT2_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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