Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
adhesion G protein-coupled receptor L2
Synonyms:
Lphn2,  Lec1,  Lphh1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Adgrl2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Adgrl2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Congenital Heart Defects, Multiple Types, 6
Double outlet right ventricle, Secundum atrial septal defect, Pulmonic stenosis, Single ventricle... OMIM:613854
Right Atrial Isomerism
Atrial septal defect, Pulmonic stenosis, Single ventricle, Right atrial isomerism, Tetralogy of F... OMIM:208530
Heterotaxy, Visceral, 12, Autosomal
Double outlet right ventricle, Double inlet right ventricle, Atrial septal defect, Hypoplastic le... OMIM:619702
Ventricular Septal Defect 1
Ventricular septal defect, Pulmonic stenosis, Atrial septal defect OMIM:614429
Scimitar Syndrome
Tricuspid atresia, Double outlet right ventricle, Anomalous pulmonary venous return, Atrial septa... ORPHA:185
Microphthalmia, Syndromic 9
Atrial septal defect, Pulmonic stenosis, Single ventricle, Tetralogy of Fallot, Hypoplastic left ... OMIM:601186
Aortic Arch Interruption
Double outlet right ventricle, Bicuspid aortic valve, Aortic valve atresia, Left ventricular hype... ORPHA:2299
Cardiomyopathy, Dilated, 2D
Right atrial enlargement, Perinuclear cardiomyocyte vacuolization, Muscular ventricular septal de... OMIM:619371
Heterotaxy, Visceral, 1, X-Linked
Double outlet right ventricle, Mitral stenosis, Atrial septal defect, Hypoplastic left heart, Atr... OMIM:306955
Congenitally Corrected Transposition Of The Great Arteries
Ventricular septal defect, Abnormal aortic valve cusp morphology, Abnormal heart morphology, Righ... ORPHA:216694
Heterotaxy, Visceral, 5, Autosomal
Double outlet right ventricle, Atrial septal defect, Double inlet left ventricle, Atrioventricula... OMIM:270100
Congenital Heart Defects, Multiple Types, 4
Aortic valve stenosis, Hypoplastic left heart, Atrioventricular canal defect, Tetralogy of Fallot... OMIM:615779
Atrial Septal Defect 2
Atrial septal defect, Atrioventricular canal defect, Pulmonic stenosis, Ventricular septal defect... OMIM:607941
Congenital Tracheomalacia
Atrial septal defect, Single ventricle, Tetralogy of Fallot, Ventricular septal defect, Partial a... ORPHA:95430
Ventricular Septal Defect 3
Ventricular septal defect, Patent ductus arteriosus, Atrial septal defect OMIM:614432
Congenital Heart Defects, Multiple Types, 5
Double outlet right ventricle, Bicuspid aortic valve, Atrial septal defect, Aortic valve stenosis... OMIM:617912
Meckel Syndrome 14
Single ventricle OMIM:619879
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Abnormal cardiac septum morphology, Stillbirth, Single ventricle OMIM:308050
Myopathy, Myofibrillar, 12, Infantile-Onset, With Cardiomyopathy
Myocardial fibrosis, Left ventricular noncompaction cardiomyopathy, Right atrial enlargement, Myo... OMIM:619424
Congenital Total Pulmonary Venous Return Anomaly
Double outlet right ventricle, Cardiac total anomalous pulmonary venous connection, Atrial septal... ORPHA:99125
Congenital Tricuspid Valve Dysplasia
Tricuspid valve prolapse, Right atrial enlargement, Anomalous pulmonary venous return, Right vent... ORPHA:555874
Isolated Right Ventricular Hypoplasia
Right atrial enlargement, Atrial septal defect, Muscular ventricular septal defect, Patent forame... ORPHA:439
Cardiomyopathy, Familial Hypertrophic, 4
Right atrial enlargement, Myofiber disarray, Muscular ventricular septal defect, Ventricular sept... OMIM:115197
Congenital Gerbode Defect
Bacterial endocarditis, Right atrial enlargement, Right ventricular hypertrophy, Pulmonic stenosi... ORPHA:99095
Hypoplastic Left Heart Syndrome 2
Ventricular septal defect, Hypoplastic left heart, Aortic valve atresia, Mitral atresia OMIM:614435
Adams-Oliver Syndrome 5
Pulmonic stenosis, Right atrial enlargement, Patent foramen ovale, Right ventricular hypertrophy OMIM:616028
Cardiomyopathy, Familial Hypertrophic, 26
Left atrial enlargement, Right atrial enlargement, Hypertrophic cardiomyopathy OMIM:617047
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Restrictive cardiomyopathy, Right atrial enlargement, Pericardial effusion, Endocardial fibroelas... OMIM:619313
Familial Isolated Restrictive Cardiomyopathy
Interstitial cardiac fibrosis, Left atrial enlargement, Right atrial enlargement, Hypertrophic ca... ORPHA:75249
Atrial Septal Defect 1
Bicuspid aortic valve, Aortic valve stenosis, Secundum atrial septal defect, Atrial septal defect... OMIM:108800
Aortic Valve Disease 1
Mitral stenosis, Double outlet right ventricle, Bicuspid aortic valve, Aortic valve stenosis, Mit... OMIM:109730
Holoprosencephaly 1
Single ventricle OMIM:236100
Holoprosencephaly 2
Single ventricle OMIM:157170
Neurocardiofaciodigital Syndrome
Double inlet left ventricle, Patent ductus arteriosus, Tetralogy of Fallot, Atrial septal defect OMIM:619869
Cirrhotic Cardiomyopathy
Left ventricular hypertrophy, Right atrial enlargement, Cardiomegaly, Left atrial enlargement ORPHA:57777
Atrial Septal Defect, Coronary Sinus Type
Unroofed coronary sinus, Right atrial enlargement, Anomalous pulmonary venous return, Right ventr... ORPHA:99104
Atrial Septal Defect, Ostium Primum Type
Left atrial enlargement, Right atrial enlargement, Left ventricular hypertrophy, Right ventricula... ORPHA:99106
Familial Idiopathic Dilatation Of The Right Atrium
Right atrial enlargement, Atrial septal dilatation, Cardiomegaly, Right ventricular hypertrophy ORPHA:1677
Atrial Septal Defect, Ostium Secundum Type
Abnormal mitral valve morphology, Right atrial enlargement, Right ventricular dilatation ORPHA:99103
Nestor-Guillermo Progeria Syndrome
Left atrial enlargement, Right atrial enlargement OMIM:614008
Chronic Thromboembolic Pulmonary Hypertension
Right atrial enlargement, Right ventricular dilatation ORPHA:70591

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adgrl2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adgrl2.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Identification of Latrophilin-2 as a Novel Cell-Surface Marker for the Cardiomyogenic Lineage and Its Functional Significance in Heart Development. Circulation (June 2019) Adgrl2tm1a(EUCOMM)Hmgu Adgrl2tm1b(EUCOMM)Hmgu 31206334

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Adgrl2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Adgrl2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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