The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Phlpp1 by phenotypic similarity.
|Retinal Dysplasia, Primary||
||Falciform retinal fold, Retinal dysplasia||OMIM:312550|
|Retinoschisis, Autosomal Dominant||
||Abnormality of macular pigmentation, Peripheral retinal degeneration, Retinoschisis||OMIM:180270|
|Stargardt Disease 1||
||Retinitis pigmentosa inversa, Bull's eye maculopathy, Macular degeneration||OMIM:248200|
|Lattice Degeneration Of Retina Leading To Retinal Detachment||
||Retinal detachment, Lattice retinal degeneration||OMIM:150500|
|Reese Retinal Dysplasia||
||Remnants of the hyaloid vascular system, Retinal dysplasia||OMIM:266400|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
|MGI Allele||Allele Type||Produced|
|Phlpp1tm1a(EUCOMM)Hmgu||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|