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Gene: Slc25a2 MGI:2137907

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2
Synonyms:
Ornt2

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Slc25a2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Slc25a2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc25a2.

There are 13 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Slc25a20tm1a(EUCOMM)Wtsi Slc25a28tm1b(EUCOMM)Wtsi PMC7263671
Genomics of Otitis Media (OM): Molecular Genetics Approaches to Characterize Disease Pathophysiology. Frontiers in genetics (April 2020) Slc25a21tm1a(KOMP)Wtsi PMC7191070
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Slc25a20tm1a(EUCOMM)Wtsi Slc25a28tm1b(EUCOMM)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Slc25a20tm1a(EUCOMM)Wtsi Slc25a21tm1a(KOMP)Wtsi Slc25a21tm1b(KOMP)Wtsi Slc25a21tm1c(KOMP)Wtsi Slc25a21tm1d(KOMP)Wtsi Slc25a28tm1b(EUCOMM)Wtsi Slc25a29tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Slc25a21tm1a(KOMP)Wtsi Slc25a20tm1a(EUCOMM)Wtsi Slc25a21tm1b(KOMP)Wtsi Slc25a21tm1c(KOMP)Wtsi Slc25a21tm1d(KOMP)Wtsi Slc25a28tm1b(EUCOMM)Wtsi Slc25a29tm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Slc25a20tm1a(EUCOMM)Wtsi Slc25a28tm1b(EUCOMM)Wtsi PMC5827107
Panel 3: Genetics and Precision Medicine of Otitis Media. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (April 2017) Slc25a21tm1a(KOMP)Wtsi 28372532
Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wellcome open research (January 2016) Slc25a20tm1a(EUCOMM)Wtsi PMC5159622
A gene expression resource generated by genome-wide lacZ profiling in the mouse. Disease models & mechanisms (August 2015) Slc25a28tm1b(EUCOMM)Wtsi PMC4631787
Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene. PloS one (March 2014) Slc25a21tm1a(KOMP)Wtsi Slc25a21tm1c(KOMP)Wtsi Slc25a21tm1b(KOMP)Wtsi Slc25a21tm1d(KOMP)Wtsi PMC3958370
Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mammalian genome : official journal of the International Mammalian Genome Society (August 2013) Slc25a21tm1a(KOMP)Wtsi PMC3745610
Robust and sensitive analysis of mouse knockout phenotypes. PloS one (December 2012) Slc25a21tm1a(KOMP)Wtsi PMC3530558
A conditional knockout resource for the genome-wide study of mouse gene function. Nature (June 2011) Slc25a25tm1a(KOMP)Wtsi PMC3572410

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MGI Allele Allele Type Produced
Slc25a2tm444681(Ifitm2_intron_L1L2_GT2_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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