Gene Summary

zinc finger protein 451
Kiaa0576-hp,  4933435G09Rik,  4930515K21Rik

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal pancreas morphology Zfp451tm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal skin morphology Zfp451tm1b(EUCOMM)Hmgu HOM Early adult 0.00
decreased exploration in new environment Zfp451tm1b(EUCOMM)Hmgu HOM Early adult 3.70×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


Panel A FCS file(s)

6 Images


Panel B FCS file(s)

6 Images


XRay Images Whole Body Dorso Ventral

10 Images


XRay Images Skull Dorso Ventral Orientation

10 Images

Gross Pathology and Tissue Collection


8 Images


XRay Images Skull Lateral Orientation

10 Images


XRay Images Whole Body Lateral Orientation

10 Images



1 Images

Human diseases caused by Zfp451 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zfp451 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Duodenal Atresia
Abnormality of the pancreas, Annular pancreas ORPHA:1203
African Iron Overload
Peritonitis, Micronodular cirrhosis, Viral hepatitis, Hepatic steatosis, Hepatocellular carcinoma... ORPHA:139507
Perlman Syndrome
Hepatomegaly, Cryptorchidism, Abnormal pancreas morphology ORPHA:2849
Annular Pancreas
Annular pancreas ORPHA:675
Pancreas, Annular
Annular pancreas OMIM:167750
Campomelia, Cumming Type
Pancreatic cysts, Polysplenia, Polycystic liver disease OMIM:211890
Pancreatitis, Hereditary
Pancreatic pseudocyst, Pancreatic calcification, Exocrine pancreatic insufficiency, Pancreatitis OMIM:167800
Martinez-Frias Syndrome
Hypoplasia of the gallbladder, Pancreatic hypoplasia, Annular pancreas, Extrahepatic biliary duct... OMIM:601346
Mitchell-Riley Syndrome
Annular pancreas, Biliary atresia, Cholestasis, Pancreatic hypoplasia, Absent gallbladder, Acholi... OMIM:615710
Nephronophthisis 13
Hepatic cysts, Pancreatic cysts OMIM:614377
Permanent Neonatal Diabetes Mellitus-Pancreatic And Cerebellar Agenesis Syndrome
Aplasia/Hypoplasia of the pancreas ORPHA:65288
Senior-Loken Syndrome 8
Hepatic cysts, Pancreatic cysts OMIM:616307
Renal-Hepatic-Pancreatic Dysplasia 1
Cirrhosis, Hepatic cysts, Pancreatic cysts, Polysplenia, Biliary cirrhosis, Pancreatic fibrosis, ... OMIM:208540
Memory impairment, Apathy, Abnormal pancreas morphology, Cognitive impairment, Elevated hepatic i... ORPHA:48818
Tropical Calcific Pancreatitis
Neoplasm of the pancreas, Pancreatic calcification, Chronic pancreatitis OMIM:608189
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Hepatic cysts, Periportal fibrosis, Pancreatic cysts, Hepatomegaly, Splenomegaly, Portal hyperten... OMIM:263200
Matthew-Wood Syndrome
Cryptorchidism, Abnormal spleen morphology, Annular pancreas, Aplasia/Hypoplasia of the pancreas ORPHA:2470
Pancreatic Agenesis 2
Pancreatic hypoplasia OMIM:615935
Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism
Pancreatic cysts, Cholestasis, Hepatic fibrosis, Hepatomegaly, Hepatitis, Pancreatic hypoplasia, ... OMIM:610199
Meckel Syndrome, Type 7
Pancreatic cysts, Biliary cirrhosis, Cholestasis, Portal hypertension, Bile duct proliferation, H... OMIM:267010
Campomelia, Cumming Type
Hepatomegaly, Pancreatic cysts, Abnormality of the pancreas ORPHA:1318
Infantile Multisystem Neurologic-Endocrine-Pancreatic Disease
Exocrine pancreatic insufficiency, Hyperechogenic pancreas, Hepatomegaly, Abnormal liver parenchy... ORPHA:456312
Autosomal Recessive Polycystic Kidney Disease
Pancreatic cysts, Periportal fibrosis, Biliary hyperplasia, Cholestasis, Hepatic fibrosis, Jaundi... ORPHA:731
Igg4-Related Submandibular Gland Disease
Enlarged lacrimal glands, Sialadenitis, Abnormal salivary gland morphology, Enlargement of paroti... ORPHA:449432
Feingold Syndrome
Abnormality of the spleen, Annular pancreas ORPHA:1305
Pearson Marrow-Pancreas Syndrome
Pancreatic fibrosis OMIM:557000
Alveolar Echinococcosis
Abnormality of mesentery morphology, Hepatic cysts, Pancreatic cysts, Biliary cirrhosis, Abnormal... ORPHA:284
Nephronophthisis-Like Nephropathy 1
Pancreatic cysts, Chronic pancreatitis OMIM:613159
Von Hippel-Lindau Syndrome
Pheochromocytoma, Pancreatic cysts, Neoplasm of the pancreas, Abnormality of the liver OMIM:193300
Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly
Pancreatic cysts, Polycystic liver disease, Pancreatic fibrosis, Hepatic fibrosis, Jaundice, Bile... OMIM:208500
Shwachman-Diamond Syndrome 2
Hepatomegaly, Hyperechogenic pancreas, Exocrine pancreatic insufficiency OMIM:617941
Bohring-Opitz Syndrome
Hyperechogenic pancreas, Supernumerary nipple OMIM:605039
Acrocephalopolydactylous Dysplasia
Hepatic fibrosis, Polysplenia, Pancreatic fibrosis, Hepatomegaly OMIM:200995
Autosomal Dominant Polycystic Kidney Disease
Pituitary growth hormone cell adenoma, Hepatic cysts, Polycystic liver disease, Pancreatic cysts ORPHA:730
Kaposiform Lymphangiomatosis
Pancreatic cysts, Hepatosplenomegaly, Abnormal spleen morphology, Splenomegaly ORPHA:464329
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 1
Hepatic fibrosis, Hepatic steatosis, Pancreatic fibrosis, Hepatomegaly OMIM:616263
Congenital Alveolar Capillary Dysplasia
Absent gallbladder, Asplenia, Annular pancreas ORPHA:210122
Atelosteogenesis Type I
Abnormal pancreatic duct morphology ORPHA:1190
Spondyloepimetaphyseal Dysplasia, Krakow Type
Annular pancreas OMIM:618162
Von Hippel-Lindau Disease
Pancreatic cysts, Adrenal pheochromocytoma, Anxiety, Neoplasm of the pancreas, Pancreatic islet c... ORPHA:892
Orofaciodigital Syndrome I
Hepatic fibrosis, Hepatic cysts, Pancreatic cysts, Ovarian cyst OMIM:311200
Short-Rib Thoracic Dysplasia 8 With Or Without Polydactyly
Pancreatic fibrosis OMIM:615503
Meckel Syndrome
Cryptorchidism, Accessory spleen, Pancreatic cysts, Pancreatic fibrosis, Cystic liver disease, As... ORPHA:564
Bohring-Opitz Syndrome
Cholelithiasis, Annular pancreas, Happy demeanor ORPHA:97297
Distal Monosomy 12Q
Self-mutilation, Biliary atresia, Unilateral cryptorchidism, Annular pancreas, Pituitary adenoma ORPHA:96149
Pearson Syndrome
Exocrine pancreatic insufficiency, Hepatic steatosis, Macronodular cirrhosis, Pancreatic fibrosis... ORPHA:699
Feingold Syndrome 1
Polysplenia, Asplenia, Accessory spleen, Annular pancreas OMIM:164280
Beckwith-Wiedemann Syndrome
Cryptorchidism, Exocrine pancreatic insufficiency, Pseudohypoparathyroidism, Hepatomegaly, Spleno... ORPHA:116
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Hepatic steatosis, Jaundice, Abnormality of exocrine pancreas physiology, Aplasia/Hypoplasia of t... ORPHA:93111
Jacobsen Syndrome
Cryptorchidism, Annular pancreas OMIM:147791
Trisomy 8P
Cryptorchidism, Aplasia/Hypoplasia of the gallbladder, Annular pancreas ORPHA:264450
Rothmund-Thomson Syndrome, Type 2
Cryptorchidism, Annular pancreas OMIM:268400
Fanconi Anemia, Complementation Group D2
Cryptorchidism, Annular pancreas OMIM:227646
Orofaciodigital Syndrome Type 1
Pancreatic cysts, Abnormality of the pancreas, Exocrine pancreatic insufficiency ORPHA:2750
Thrombocytopenia-Absent Radius Syndrome
Pancreatic cysts, Hepatosplenomegaly OMIM:274000
Short-Rib Thoracic Dysplasia 6 With Or Without Polydactyly
Hepatic fibrosis, Pancreatic fibrosis OMIM:263520
Neurodevelopmental Disorder With Or Without Anomalies Of The Brain, Eye, Or Heart
Cryptorchidism, Annular pancreas OMIM:616975
Telo2-Related Intellectual Disability-Neurodevelopmental Disorder
Annular pancreas ORPHA:488642
Jacobsen Syndrome
Cryptorchidism, Annular pancreas ORPHA:2308
1P36 Deletion Syndrome
Cryptorchidism, Hepatic steatosis, Self-injurious behavior, Abnormality of the spleen, Abnormalit... ORPHA:1606
Fryns Syndrome
Ectopic pancreatic tissue, Cryptorchidism, Polysplenia OMIM:229850
Schinzel-Giedion Syndrome
Hepatoblastoma, Streak ovary, Annular pancreas ORPHA:798
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Asplenia, Annular pancreas OMIM:265380


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp451

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp451.

No publications found that use IMPC mice or data for Zfp451.

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MGI Allele Allele Type Produced
Zfp451tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Zfp451tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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