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Gene: Setd4 MGI:2136890

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Gene Summary

Name:
SET domain containing 4
Synonyms:
ORF21

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased fasting circulating glucose level Setd4tm1a(KOMP)Wtsi HOM Early adult 7.28×10-05
increased circulating aspartate transaminase level Setd4tm1a(KOMP)Wtsi HOM Early adult 5.52×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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X-ray

XRay Images Forepaw

12 Images

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X-ray

XRay Images Skull Lateral Orientation

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

15 Images

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Legacy Phenotype Associated Images
Setd4tm1a(KOMP)Wtsi
HOM, Male, WTSI
Setd4tm1a(KOMP)Wtsi
HOM, Male, WTSI
Setd4tm1a(KOMP)Wtsi
HOM, Male, WTSI
Setd4tm1a(KOMP)Wtsi
HOM, Male, WTSI
Setd4tm1a(KOMP)Wtsi
HOM, Male, WTSI

View all 69 images

Setd4tm1a(KOMP)Wtsi
abnormal retinal pigmentation, HOM, Male, WTSI
Setd4tm1a(KOMP)Wtsi
abnormal retinal pigmentation, HOM, Female, WTSI
Setd4tm1a(KOMP)Wtsi
abnormal placement of pupils, abnormal pupil morphology, HOM, Female, WTSI
Setd4tm1a(KOMP)Wtsi
left eye, HOM, Female, WTSI
Setd4tm1a(KOMP)Wtsi
abnormal retinal pigmentation, HOM, Male, WTSI

Human diseases caused by Setd4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Setd4 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cramps, Familial Adolescent
Elevated circulating creatine kinase concentration OMIM:218050
Muscle Cramps, Familial
Elevated circulating creatine kinase concentration OMIM:158400
Pentosuria
Abnormal circulating carbohydrate concentration, Abnormality of circulating enzyme level ORPHA:2843
Hyperinsulinism Due To Insr Deficiency
Hypoglycemia, Insulin resistance, Fasting hyperinsulinemia, Abnormal circulating C-peptide concen... ORPHA:263458
Isolated Asymptomatic Elevation Of Creatine Phosphokinase
Elevated creatine kinase after exercise, Elevated circulating creatine kinase concentration ORPHA:206599
3-Hydroxy-3-Methylglutaryl-Coa Synthase Deficiency
Hypoglycemia ORPHA:35701
Hyperinsulinemic Hypoglycemia, Familial, 7
Hyperinsulinemia, Hypoglycemia, Hypoglycemic seizures, Hyperinsulinemic hypoglycemia OMIM:610021

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Setd4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Setd4.

There are 7 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Setd4tm1a(KOMP)Wtsi PMC7263671
Deletion of Mouse Setd4 Promotes the Recovery of Hematopoietic Failure. International journal of radiation oncology, biology, physics (April 2020) Setd4tm1c(KOMP)Wtsi PMC7321877
Loss of Setd4 delays radiation-induced thymic lymphoma in mice. DNA repair (November 2019) Setd4tm1c(KOMP)Wtsi Setd4tm1a(KOMP)Wtsi PMC6960333
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Setd4tm1a(KOMP)Wtsi PMC6671969
The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages. Molecular immunology (July 2019) Setd4tm1a(KOMP)Wtsi Setd4tm1b(KOMP)Wtsi 31376731
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Setd4tm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Setd4tm1a(KOMP)Wtsi PMC5827107

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Setd4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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