Gene: Pcdhb22

Name
protocadherin beta 22
MGI ID
MGI:2136760
Synonyms
Pcdhb15 PcdhbV
Viability
Homozygous - Viable
Other links
Significant phenotypes (0) All measurements (91) Expression & images (73) Disease models (0) Order (2)
View data by physiological system
Significant
Not Significant
Not tested

Filtered by: all phenotypes

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Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Bulging eye HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / PQ HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.522 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Light sleep bout lengths standard deviation HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_008_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / RR HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.327 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Light-Dark Test / Percent time in light HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.000771 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Iris/Pupil HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Body Composition (DEXA lean/fat) / Lean/Body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.969 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Light-Dark Test / Side changes HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0544 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / rMSSD HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.814 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Corneal Sclerization HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Distance travelled - total HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.400 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Eye Hemorrhage or Blood Presence HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / PR HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.327 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Dark sleep bout lengths mean HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_009_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Synechia HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Number of rears - total HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.766 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Light-Dark Test / Light side time spent HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0819 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Periphery permanence time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.651 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Pupil Position HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Body Composition (DEXA lean/fat) / Fat/Body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0869 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Corneal deposits HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / HR HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.299 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.838 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Body Composition (DEXA lean/fat) / Bone Area HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.139 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Percentage center time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.651 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Eyelid closure HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Fusion between cornea and lens HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Light-Dark Test / Time mobile light side HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0214 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Body Composition (DEXA lean/fat) / Body length HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.248 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Breath rate during sleep standard deviation HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_014_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.000151 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Lens Opacity HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Iris transilumination HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / CV HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.641 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Eyelid morphology HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Periphery distance travelled HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.123 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Body Composition (DEXA lean/fat) / BMC/Body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0783 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Sleep daily percent HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_002_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Light-Dark Test / Dark side time spent HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0819 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Sleep light phase percent HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_003_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Cornea HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Retina (combined) HOM 8f:8m Not processed Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Center permanence time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.651 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Whole arena resting time HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.326 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Vitreous HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Lens HOM 8f:8m Fisher Exact Test framework 0.851 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Peak wake with respect to dark onset median HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_012_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / QTc HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.266 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull) HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0817 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Optic Disc HOM 8f:8m Fisher Exact Test framework 0.0481 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Light-Dark Test / Time mobile dark side HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.622 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Center average speed HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.411 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Light-Dark Test / Fecal boli HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.744 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Retinal Blood Vessels Structure HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Narrow eye opening HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Fertility of Homozygous Knock-out Mice / Gross Findings Female HOM f:m Supplied as data Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Sleep dark phase percent HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_004_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Iris Pigmentation HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull) HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0448 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.454 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / HRV HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.537 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Breath rate during sleep mean HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_013_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1 HOM 8f:8m Mixed Model framework, generalized least squares, equation withoutWeight 0.900 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Retinal Blood Vessels HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / QRS HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.139 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Pupil Dilation HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.923 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Body Composition (DEXA lean/fat) / Fat mass HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.933 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Persistence of hyaloid vascular system HOM 8f:8m Fisher Exact Test framework 0.260 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Sleep bout lengths mean HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_005_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.564 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Light-Dark Test / Latency to first transition into dark HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.569 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.710 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Pupil Shape HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Viability Primary Screen / Outcome HOM 51f:50m Supplied as data Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Periphery average speed HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.197 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / QTc Dispersion HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.246 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Fertility of Homozygous Knock-out Mice / Gross Findings Male HOM f:m Supplied as data Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Eye HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Body Composition (DEXA lean/fat) / Lean mass HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0619 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Dark sleep bout lengths standard deviation HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_010_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Pupil Light Response HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Whole arena average speed HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.406 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Corneal opacity HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Electrocardiogram (ECG) / ST HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.888 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Light sleep bout lengths mean HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_007_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Open Field / Center distance travelled HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.683 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Sleep Wake / Sleep bout lengths standard deviation HOM 2f:5m Not processed 1.00 FAILED - Not enough data points in dependent variable 'JAX_SLW_006_001' for genotype/sex combinations to allow the application of MM/TF framework. Threshold used: 4.
Pcdhb22tm1.1(KOMP)Vlcg JAX Light-Dark Test / Percent time in dark HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.000771 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Corneal vascularization HOM 8f:8m Fisher Exact Test framework 1.00 Success
Pcdhb22tm1.1(KOMP)Vlcg JAX Eye Morphology / Retinal Blood Vessels Pattern HOM 8f:8m Fisher Exact Test framework 1.00 Success

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132)  (1/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485) N/A
Dorsal root ganglion 1  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Fronto-nasal process 1  (1/48) N/A
Hand 2  (1/485) N/A
Head 2  (5/485) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Nose 1  (1/51) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Spinal cord 1  (1/50) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

Sleep Wake: Wake state (bmp file)
7 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Pcdhb22tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Pcdhb22tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice

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