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Gene: Gorasp2 MGI:2135962

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

golgi reassembly stacking protein 2

Synonyms:

ENSMUSG00000075299, 9430094F20Rik, GOLPH2, 5730520M13Rik, p59, GRASP55, GRS2

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gorasp2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Gorasp2 (0 diseases)
Human diseases predicted to be associated with Gorasp2 (193 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gorasp2 by phenotypic similarity.

Disease	Matching phenotypes	Source
Spermatogenic Failure 65	Reduced progressive sperm motility, Short sperm flagella, Coiled sperm flagella, Absent sperm fla...	OMIM:619712
Spermatogenic Failure 56	Reduced progressive sperm motility, Short sperm flagella, Coiled sperm flagella, Absent sperm fla...	OMIM:619515
Spermatogenic Failure, X-Linked, 3	Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertility, Irregularly...	OMIM:301059
Spermatogenic Failure 40	Immotile sperm, Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertil...	OMIM:618664
Spermatogenic Failure 76	Short sperm flagella, Irregularly shaped sperm tail, Absent sperm flagella, Male infertility, Oli...	OMIM:620084
Spermatogenic Failure 80	Reduced progressive sperm motility, Short sperm flagella, Coiled sperm flagella, Absent sperm fla...	OMIM:620222
Spermatogenic Failure 58	Reduced progressive sperm motility, Immotile sperm, Short sperm flagella, Irregularly shaped sper...	OMIM:619585
Spermatogenic Failure 54	Cryptozoospermia, Oligospermia, Short sperm flagella, Coiled sperm flagella, Abnormal sperm axone...	OMIM:619379
Spermatogenic Failure 47	Immotile sperm, Short sperm flagella, Absent sperm flagella, Male infertility, Oligospermia	OMIM:619102
Spermatogenic Failure 11	Abnormal sperm morphology, Oligospermia, Reduced sperm motility, Male infertility	OMIM:615081
Spermatogenic Failure 10	Abnormal sperm morphology, Oligospermia, Reduced sperm motility, Male infertility	OMIM:614822
Male Infertility Due To Acephalic Spermatozoa	Acephalic spermatozoa, Reduced sperm motility, Male infertility, Oligospermia, Abnormal sperm mid...	ORPHA:529970
Spermatogenic Failure 79	Coiled sperm flagella, Reduced sperm motility, Male infertility, Oligospermia	OMIM:620196
Spermatogenic Failure 39	Oligospermia, Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertilit...	OMIM:618643
Spermatogenic Failure 72	Reduced progressive sperm motility, Absent sperm axoneme central pair complex, Short sperm flagel...	OMIM:619867
Spermatogenic Failure 34	Absent sperm axoneme central pair complex, Short sperm flagella, Coiled sperm flagella, Absent sp...	OMIM:618153
Spermatogenic Failure 37	Short sperm flagella, Coiled sperm flagella, Irregularly shaped sperm tail, Absent sperm flagella...	OMIM:618429
Spermatogenic Failure 18	Short sperm flagella, Coiled sperm flagella, Irregularly shaped sperm tail, Absent sperm flagella...	OMIM:617576
Spermatogenic Failure 46	Short sperm flagella, Coiled sperm flagella, Irregularly shaped sperm tail, Absent sperm flagella...	OMIM:619095
Spermatogenic Failure 27	Absent sperm axoneme central pair complex, Short sperm flagella, Coiled sperm flagella, Absent sp...	OMIM:617965
Spermatogenic Failure 33	Short sperm flagella, Coiled sperm flagella, Irregularly shaped sperm tail, Absent sperm flagella...	OMIM:618152
Spermatogenic Failure 41	Immotile sperm, Short sperm flagella, Male infertility, Tapered sperm head, Oligospermia	OMIM:618670
Spermatogenic Failure 51	Macrocephalic sperm head, Microcephalic sperm head, Absent sperm axoneme central pair complex, Sh...	OMIM:619177
Spermatogenic Failure 43	Absent sperm axoneme central pair complex, Coiled sperm flagella, Absent sperm flagella, Male inf...	OMIM:618751
Spermatogenic Failure 45	Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertility, Reduced spe...	OMIM:619094
Spermatogenic Failure 19	Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertility, Reduced spe...	OMIM:617592
Spermatogenic Failure 49	Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Male infertility, Reduced spe...	OMIM:619144
Spermatogenic Failure 7	Immotile sperm, Reduced sperm motility, Male infertility, Oligospermia	OMIM:612997
Spermatogenic Failure 35	Absent sperm axoneme central pair complex, Short sperm flagella, Coiled sperm flagella, Absent sp...	OMIM:618341
Spermatogenic Failure 64	Abnormal sperm head morphology, Reduced progressive sperm motility, Oligospermia, Male infertility	OMIM:619696
Spermatogenic Failure 63	Reduced progressive sperm motility, Decreased testicular size, Oligospermia, Male infertility	OMIM:619689
Spermatogenic Failure 20	Coiled sperm flagella, Absent sperm flagella, Male infertility, Short sperm flagella	OMIM:617593
Spermatogenic Failure 42	Microcephalic sperm head, Short sperm flagella, Coiled sperm flagella, Absent sperm flagella, Mal...	OMIM:618745
Spermatogenic Failure 1	Male infertility, Oligospermia, Cryptozoospermia	OMIM:258150
Spermatogenic Failure 36	Abnormal sperm morphology, Male infertility	OMIM:618420
Deafness, Autosomal Recessive 32, With Or Without Immotile Sperm	Abnormal sperm morphology, Immotile sperm, Male infertility	OMIM:608653
Spermatogenic Failure 70	Azoospermia, Reduced sperm motility, Male infertility, Oligospermia	OMIM:619828
Spermatogenic Failure 48	Azoospermia, Spermatogenesis maturation arrest, Oligospermia, Male infertility	OMIM:619108
Partial Chromosome Y Deletion	Decreased testicular size, Cryptorchidism, Non-obstructive azoospermia, Male infertility, Abnorma...	ORPHA:1646
Spermatogenic Failure 25	Decreased testicular size, Early spermatogenesis maturation arrest, Cryptozoospermia, Non-obstruc...	OMIM:617960
Spermatogenic Failure 78	Microcephalic sperm head, Male infertility, Tapered sperm head	OMIM:620170
Spermatogenic Failure 44	Acephalic spermatozoa, Reduced sperm motility, Male infertility	OMIM:619044
Spermatogenic Failure 16	Acephalic spermatozoa, Reduced sperm motility, Male infertility	OMIM:617187
Spermatogenic Failure 21	Acephalic spermatozoa, Reduced sperm motility, Male infertility	OMIM:617644
Spermatogenic Failure 30	Cryptorchidism, Spermatogenesis maturation arrest, Cryptozoospermia, Azoospermia, Male infertility	OMIM:618110
Deafness-Infertility Syndrome	Abnormal sperm head morphology, Abnormal sperm tail morphology, Male infertility, Abnormal sperma...	OMIM:611102
Spermatogenic Failure 24	Microcephalic sperm head, Short sperm flagella, Coiled sperm flagella, Tapered sperm head, Reduce...	OMIM:617959
Spermatogenic Failure 22	Non-obstructive azoospermia, Male infertility, Cryptozoospermia	OMIM:617706
Spermatogenic Failure 29	Non-obstructive azoospermia, Immotile sperm, Male infertility	OMIM:618091
Spermatogenic Failure 5	Macrocephalic sperm head, Multiflagellar spermatozoa, Male infertility	OMIM:243060
Spermatogenic Failure 38	Abnormal sperm head morphology, Abnormal axonemal organization of respiratory motile cilia, Oligo...	OMIM:618433
Spermatogenic Failure 8	Azoospermia, Oligospermia, Cryptozoospermia	OMIM:613957
Spermatogenic Failure 62	Non-obstructive azoospermia, Male infertility, Early spermatogenesis maturation arrest	OMIM:619673
Spermatogenic Failure 61	Non-obstructive azoospermia, Male infertility, Early spermatogenesis maturation arrest	OMIM:619672
Spermatogenic Failure 73	Non-obstructive azoospermia, Spermatogenesis maturation arrest, Male infertility	OMIM:619878
Spermatogenic Failure 59	Non-obstructive azoospermia, Spermatogenesis maturation arrest, Male infertility	OMIM:619645
Spermatogenic Failure 60	Non-obstructive azoospermia, Spermatogenesis maturation arrest, Male infertility	OMIM:619646
Spermatogenic Failure 74	Non-obstructive azoospermia, Spermatogenesis maturation arrest, Male infertility	OMIM:619937
Spermatogenic Failure 31	Acephalic spermatozoa, Male infertility	OMIM:618112
Spermatogenic Failure 26	Acephalic spermatozoa, Male infertility	OMIM:617961
Spermatogenic Failure 53	Tapered sperm head, Male infertility	OMIM:619258
Spermatogenic Failure 57	Non-obstructive azoospermia, Decreased testicular size, Spermatogenesis maturation arrest, Male i...	OMIM:619528
Spermatogenic Failure 50	Azoospermia, Decreased testicular size, Spermatogenesis maturation arrest, Male infertility	OMIM:619145
Spermatogenic Failure 32	Non-obstructive azoospermia, Sertoli cell-only phenotype, Male infertility	OMIM:618115
Spermatogenic Failure 71	Non-obstructive azoospermia, Sertoli cell-only phenotype, Male infertility	OMIM:619831
Spermatogenic Failure 3	Reduced sperm motility, Male infertility	OMIM:606766
Spermatogenic Failure, Y-Linked, 1	Reduced sperm motility, Male infertility	OMIM:400042
Spermatogenic Failure 55	Reduced sperm motility, Male infertility	OMIM:619380
Spermatogenic Failure 6	Globozoospermia, Decreased acrosin in sperm head, Male infertility	OMIM:102530
Isochromosomy Yp	Azoospermia, Decreased testicular size, Male infertility, Ambiguous genitalia	ORPHA:98797
Male Infertility With Teratozoospermia Due To Single Gene Mutation	Globozoospermia, Abnormal sperm morphology, Decreased testicular size, Abnormal sperm tail morpho...	ORPHA:399808
Spermatogenic Failure, Y-Linked, 2	Azoospermia, Male infertility	OMIM:415000
Spermatogenic Failure 4	Azoospermia, Male infertility	OMIM:270960
Spermatogenic Failure 52	Azoospermia, Male infertility	OMIM:619202
Spermatogenic Failure 23	Azoospermia, Male infertility	OMIM:617707
Spermatogenic Failure 12	Infertility, Abnormal male germ cell morphology, Azoospermia	OMIM:615413
Spermatogenic Failure 66	Globozoospermia, Male infertility	OMIM:619799
Spermatogenic Failure 67	Globozoospermia, Male infertility	OMIM:619803
Spermatogenic Failure 68	Globozoospermia, Male infertility	OMIM:619805
Spermatogenic Failure 9	Globozoospermia, Male infertility	OMIM:613958
Spermatogenic Failure 69	Globozoospermia, Male infertility	OMIM:619826
Spermatogenic Failure 17	Male infertility	OMIM:617214
Deafness-Infertility Syndrome	Azoospermia, Male infertility	ORPHA:94064
Isochromosomy Yq	Decreased testicular size, Ambiguous genitalia, Varicocele, Azoospermia, Gonadal tissue inappropr...	ORPHA:98798
Young Syndrome	Decreased fertility, Obstructive azoospermia	ORPHA:3471
Spermatogenic Failure 2	Non-obstructive azoospermia, Azoospermia, Oligospermia, Male infertility	OMIM:108420
Spermatogenic Failure 77	Cryptorchidism, Azoospermia, Multiflagellar spermatozoa, Male infertility, Oligospermia	OMIM:620103
Spermatogenic Failure, X-Linked, 2	Azoospermia, Spermatogenesis maturation arrest, Testicular atrophy, Male infertility	OMIM:309120
Spermatogenic Failure 13	Azoospermia	OMIM:615841
Deleted in azoospermia	Azoospermia	OMIM:400003
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation	Decreased testicular size, Obstructive azoospermia, Non-obstructive azoospermia, Azoospermia, Abn...	ORPHA:399805
Spermatogenic Failure 75	Non-obstructive azoospermia, Male infertility, Early spermatogenesis maturation arrest	OMIM:619949
Female Infertility Due To Oocyte Meiotic Arrest	Abnormal meiosis, Polycystic ovaries, Oocyte arrest at metaphase I, Female infertility, Abnormal ...	ORPHA:488191
Hypogonadism With Low-Grade Mental Deficiency And Microcephaly	Male hypogonadism, Azoospermia	OMIM:241000
Familial Peripheral Male-Limited Precocious Puberty	Male infertility, Long penis, Macroorchidism, Oligospermia, Precocious puberty	ORPHA:3000
Congenital Bilateral Absence Of Vas Deferens	Absent vas deferens, Obstructive azoospermia, Male infertility, Oligospermia	ORPHA:48
Azoospermia, Obstructive, With Nephrolithiasis	Male infertility, Obstructive azoospermia, Spermatocele	OMIM:301060
Spermatogenic Failure 15	Non-obstructive azoospermia, Spermatogenesis maturation arrest, Male infertility	OMIM:616950
Persistent Mullerian Duct Syndrome, Types I And Ii	Bilateral cryptorchidism, Male infertility	OMIM:261550
Ring Chromosome Y Syndrome	Perineal hypospadias, Cryptorchidism, Ambiguous genitalia, Gonadoblastoma, Ambiguous genitalia, m...	ORPHA:261529
Ciliary Dyskinesia, Primary, 41	Infertility, Immotile sperm	OMIM:618449
Morbid Obesity And Spermatogenic Failure	Infertility, Azoospermia, Oligospermia	OMIM:615703
Young Syndrome	Azoospermia	OMIM:279000
Spinocerebellar Ataxia Type 32	Azoospermia, Testicular atrophy, Male infertility	ORPHA:276183
Isolated Follicle Stimulating Hormone Deficiency	Oligomenorrhea, Delayed puberty, Abnormal sperm morphology, Decreased testicular size, Testicular...	ORPHA:52901
Spinocerebellar Ataxia 32	Infertility, Azoospermia, Testicular atrophy	OMIM:613909
Spermatogenic Failure 28	Non-obstructive azoospermia, Decreased testicular size, Male infertility	OMIM:618086
Vas Deferens, Congenital Bilateral Aplasia Of, X-Linked	Absent vas deferens, Azoospermia, Male infertility	OMIM:300985
Vas Deferens, Congenital Bilateral Aplasia Of	Azoospermia, Absent vas deferens, Male infertility	OMIM:277180
Spermatogenic Failure 14	Azoospermia, Late spermatogenesis maturation arrest, Male infertility	OMIM:615842
Lissencephaly, X-Linked, 1	Micropenis, Gray matter heterotopia, Pachygyria, Agyria, Lissencephaly, Postnatal growth retardation	OMIM:300067
Ciliary Dyskinesia, Primary, 49, Without Situs Inversus	Coiled sperm flagella, Male infertility, Short sperm flagella	OMIM:620197
Hypogonadotropic Hypogonadism 24 With Or Without Anosmia	Decreased testicular size, Hypogonadism, Primary amenorrhea, Infertility, Azoospermia	OMIM:229070
Autosomal Recessive Spastic Paraplegia Type 46	Abnormal sperm head morphology, Abnormal sperm morphology, Decreased testicular size, Infertility...	ORPHA:320391
Ciliary Dyskinesia, Primary, 34	Immotile sperm, Male infertility, Absent central microtubular pair morphology of respiratory moti...	OMIM:617091
Spermatogenic Failure, X-Linked, 4	Azoospermia, Male infertility	OMIM:301077
Ciliary Dyskinesia, Primary, 12	Immotile sperm, Abnormal central microtubular pair morphology of respiratory motile cilia, Short ...	OMIM:612650
Spondylometaphyseal Dysplasia, Axial	Rhizomelia, Disproportionate short-trunk short stature, Reduced sperm motility, Short stature	OMIM:602271
Ciliary Dyskinesia, Primary, 46	Reduced sperm motility	OMIM:619436
Ciliary Dyskinesia, Primary, 11	Abnormal central microtubular pair morphology of respiratory motile cilia, Short stature, Reduced...	OMIM:612649
Mayer-Rokitansky-Küster-Hauser Syndrome Type 2	Aplasia/hypoplasia of the uterus, Azoospermia, Short stature, Bicornuate uterus	ORPHA:2578
Ciliary Dyskinesia, Primary, 45	Male infertility, Absent inner and outer dynein arms	OMIM:618801
Adrenal Hypoplasia, Congenital	Delayed puberty, Cryptorchidism, Azoospermia, Oligospermia, Hypogonadotropic hypogonadism, Precoc...	OMIM:300200
Androgen Insensitivity, Partial	Perineal hypospadias, Cryptorchidism, Micropenis, Hypogonadism, Infertility, Azoospermia, Absent ...	OMIM:312300
Hydrocephalus-Obesity-Hypogonadism Syndrome	Azoospermia, Short stature, Hypergonadotropic hypogonadism	ORPHA:2183
Torticollis, Keloids, Cryptorchidism, And Renal Dysplasia	Cryptorchidism, Oligospermia	OMIM:314300
Ciliary Dyskinesia, Primary, 18	Absent outer dynein arms, Immotile sperm, Male infertility, Absent inner dynein arms	OMIM:614874
Premature Ovarian Failure 10	Premature ovarian insufficiency, Decreased testicular size, Hypoplasia of the ovary, Primary amen...	OMIM:612885
Leukoencephalopathy With Dystonia And Motor Neuropathy	Azoospermia, Hypergonadotropic hypogonadism	OMIM:613724
47,Xyy Syndrome	Cryptorchidism, Micropenis, Varicocele, Azoospermia, Male infertility, Macroorchidism, Oligosperm...	ORPHA:8
Ciliary Dyskinesia, Primary, 14	Abnormal axonemal organization of respiratory motile cilia, Immotile sperm, Absent inner dynein a...	OMIM:613807
Hemochromatosis, Type 2A	Infertility, Amenorrhea, Azoospermia, Hypogonadotropic hypogonadism	OMIM:602390
Ciliary Dyskinesia, Primary, 26	Infertility, Absent outer dynein arms, Reduced sperm motility	OMIM:615500
Hypogonadotropic Hypogonadism 23 With Or Without Anosmia	Oligomenorrhea, Delayed puberty, Secondary amenorrhea, Abnormality of the Leydig cells, Micropeni...	OMIM:228300
Functioning Gonadotropic Adenoma	Delayed puberty, Isosexual precocious puberty, Decreased female libido, Infertility, Abnormality ...	ORPHA:91348
Androgen Insensitivity Syndrome	Delayed puberty, Aplasia/Hypoplasia of the fallopian tube, Cryptorchidism, Abnormal morphology of...	ORPHA:754
Ciliary Dyskinesia With Defective Radial Spokes	Immotile sperm, Absent respiratory ciliary axoneme radial spokes	OMIM:242670
Ciliary Dyskinesia, Primary, 36, X-Linked	Male infertility	OMIM:300991
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia	Decreased testicular size, Cryptorchidism, Micropenis, Primary amenorrhea, Hypoplasia of the uter...	OMIM:614837
Heterotaxy, Visceral, 9, Autosomal, With Male Infertility	Male infertility	OMIM:618948
Ciliary Dyskinesia, Primary, 15	Infertility, Immotile sperm, Abnormal axonemal organization of respiratory motile cilia	OMIM:613808
Maternal Uniparental Disomy Of Chromosome X	Azoospermia, Gonadal tissue inappropriate for external genitalia or chromosomal sex, Short statur...	ORPHA:261519
Testicular Germ Cell Tumor	Azoospermia	OMIM:273300
Lead Poisoning	Delayed puberty, Abnormal sperm morphology, Decreased male libido, Decreased female libido, Infer...	ORPHA:330015
Partial Androgen Insensitivity Syndrome	Perineal hypospadias, Micropenis, Ambiguous genitalia, Primary amenorrhea, Fused labia majora, Cl...	ORPHA:90797
Mullerian Duct Aplasia, Unilateral Renal Agenesis, And Cervicothoracic Somite Anomalies	Azoospermia, Short stature, Hypoplasia of the uterus, Bicornuate uterus	OMIM:601076
Hypogonadotropic Hypogonadism 16 With Or Without Anosmia	Decreased testicular size, Cryptorchidism, Micropenis, Hypogonadism, Primary amenorrhea, Azoospermia	OMIM:614897
Ring Chromosome 21 Syndrome	Infertility, Amenorrhea, Azoospermia, Short stature	ORPHA:1445
Ciliary Dyskinesia, Primary, 40	Infertility, Absent outer dynein arms, Azoospermia	OMIM:618300
Ciliary Dyskinesia, Primary, 22	Infertility, Reduced sperm motility, Absent inner and outer dynein arms	OMIM:615444
Anemia, Hypochromic Microcytic, With Iron Overload 2	Azoospermia, Hypogonadism, Growth delay	OMIM:615234
Pituitary Dermoid And Epidermoid Cysts	Oligomenorrhea, Oligospermia, Amenorrhea, Hypogonadism	ORPHA:91351
Ciliary Dyskinesia, Primary, 9	Absent outer dynein arms, Male infertility	OMIM:612444
Moyamoya Angiopathy-Short Stature-Facial Dysmorphism-Hypergonadotropic Hypogonadism Syndrome	Delayed puberty, Decreased testicular size, Short stature, Hypergonadotropic hypogonadism, Azoosp...	ORPHA:280679
Retinitis Pigmentosa 82 With Or Without Situs Inversus	Reduced sperm motility	OMIM:615434
46,Xx Sex Reversal 2	Perineal hypospadias, Micropenis, Hypoplasia of the vagina, Hypoplasia of the uterus, Azoospermia...	OMIM:278850
46,Xy Partial Gonadal Dysgenesis	Delayed puberty, Ambiguous genitalia, Primary amenorrhea, Abnormal internal genitalia, Testicular...	ORPHA:251510
Myotonic Dystrophy 2	Oligospermia, Hypogonadism	OMIM:602668
46,Xx Sex Reversal 1	Clitoral hypertrophy, Azoospermia, Ovotestis, Bicornuate uterus, True hermaphroditism, Sex revers...	OMIM:400045
Normosmic Congenital Hypogonadotropic Hypogonadism	Delayed puberty, Hypoplasia of the ovary, Cryptorchidism, Decreased testicular size, Micropenis, ...	ORPHA:432
Generalized Glucocorticoid Resistance Syndrome	Oligomenorrhea, Ambiguous genitalia, Infertility, Female pseudohermaphroditism, Oligospermia, Pre...	ORPHA:786
Gapo Syndrome	Dysmenorrhea, Hypogonadism, Short stature, Growth delay, Oligospermia, Amenorrhea	ORPHA:2067
Complete Androgen Insensitivity Syndrome	Delayed puberty, Aplasia/Hypoplasia of the fallopian tube, Abnormal morphology of female internal...	ORPHA:99429
Ciliary Dyskinesia, Primary, 5	Reduced sperm motility	OMIM:608647
Ciliary Dyskinesia, Primary, 19	Male infertility, Absent inner and outer dynein arms	OMIM:614935
Heterotaxy, Visceral, 11, Autosomal, With Male Infertility	Reduced progressive sperm motility	OMIM:619608
Hereditary Amyloidosis With Primary Renal Involvement	Hypogonadism, Primary testicular failure, Male infertility, Abnormal testis morphology, Oligospermia	ORPHA:85450
Classic Galactosemia	Oligomenorrhea, Delayed puberty, Decreased fertility in females, Cryptorchidism, Premature ovaria...	ORPHA:79239
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia	Decreased testicular size, Cryptorchidism, Testicular atrophy, Micropenis, Azoospermia, Small scr...	OMIM:308700
Hemochromatosis, Type 1	Testicular atrophy, Azoospermia, Impotence, Hypogonadotropic hypogonadism, Amenorrhea	OMIM:235200
Heterotaxy, Visceral, 10, Autosomal, With Male Infertility	Male infertility	OMIM:619607
Familial Isolated Hypoparathyroidism Due To Agenesis Of Parathyroid Gland	Male infertility	ORPHA:2239
Short Stature, Onychodysplasia, Facial Dysmorphism, And Hypotrichosis	Rhizomelia, Clitoral hypoplasia, Oligospermia, Growth delay	OMIM:614813
Bloom Syndrome	Premature ovarian insufficiency, Severe postnatal growth retardation, Intrauterine growth retarda...	ORPHA:125
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency	Delayed puberty, Micropenis, Primary amenorrhea, Ambiguous genitalia, male, Precocious puberty in...	ORPHA:90793
Primary Ciliary Dyskinesia	Female infertility, Abnormal sperm motility, Male infertility	ORPHA:244
45,X/46,Xy Mixed Gonadal Dysgenesis	Delayed puberty, Ambiguous genitalia, Abnormal internal genitalia, Streak ovary, Bilateral crypto...	ORPHA:1772
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts	Azoospermia, Hypogonadism, Growth delay	ORPHA:300298
Aromatase Deficiency	Cryptorchidism, Primary amenorrhea, Hypergonadotropic hypogonadism, Female infertility, Male infe...	ORPHA:91
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency	Decreased testicular size, Cryptorchidism, Penoscrotal hypospadias, Ambiguous genitalia, male, Cl...	ORPHA:90791
Polyendocrine-Polyneuropathy Syndrome	Postnatal growth retardation, Decreased testicular size, Hypogonadotropic hypogonadism, Short sta...	OMIM:616113
Congenital Adrenal Hyperplasia Due To Cytochrome P450 Oxidoreductase Deficiency	Delayed puberty, Increased size of the clitoris, Cryptorchidism, Micropenis, Ambiguous genitalia,...	ORPHA:95699
Ciliary Dyskinesia, Primary, 1	Absent outer dynein arms, Male infertility	OMIM:244400
Carney Complex	Testicular adrenal rest tumor, Abnormal morphology of female internal genitalia, Abnormal sperm m...	ORPHA:1359
Autosomal Dominant Polycystic Kidney Disease	Reduced sperm motility	ORPHA:730
Fanconi Anemia, Complementation Group A	Male infertility, Cryptorchidism, Short stature, Hypergonadotropic hypogonadism	OMIM:227650
Tetrasomy 9P	Polymicrogyria, Cryptorchidism, Micropenis, Intrauterine growth retardation, Infertility, Pachygy...	ORPHA:3310
Coccidioidomycosis	Abnormal sperm morphology, Abnormality of the male genitalia, Abnormality of the female genitalia	ORPHA:228123
Renal Cysts And Diabetes Syndrome	Hypoplasia of the uterus, Epididymal cyst, Atretic vas deferens, Bicornuate uterus, Reduced sperm...	OMIM:137920
Noonan Syndrome 1	Cryptorchidism, Hypogonadism, Short stature, Male infertility, Postnatal growth retardation, Hypo...	OMIM:163950
Cystinosis, Nephropathic	Delayed puberty, Short stature, Male infertility, Growth delay, Male hypogonadism	OMIM:219800
Cystic Fibrosis	Male infertility	OMIM:219700
Alström Syndrome	Decreased testicular size, Micropenis, Polycystic ovaries, Precocious puberty in females, Testicu...	ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gorasp2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gorasp2.

There are 3 publications which use IMPC produced mice or data.

Title	Journal	IMPC Allele	PubMed ID
The function of GORASPs in Golgi apparatus organization in vivo.	The Journal of cell biology (September 2020)	Gorasp2^{tm1c(EUCOMM)Hmgu} Gorasp2^{tm1a(EUCOMM)Hmgu}	32573693
Grasp55-/- mice display impaired fat absorption and resistance to high-fat diet-induced obesity.	Nature communications (March 2020)	Gorasp2^{tm1(KOMP)Vlcg}	PMC7078302
GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion.	Developmental cell (March 2019)	Gorasp2^{tm1c(EUCOMM)Hmgu} Gorasp2^{tm1a(EUCOMM)Hmgu} Gorasp2^{tm1d(EUCOMM)Hmgu}	30880003

Order Mouse and ES Cells

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MGI Allele	Allele Type	Produced
Gorasp2^{tm27337(L1L2_gt0)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Gorasp2^{tm1e(EUCOMM)Hmgu}	Targeted, non-conditional allele	ES Cells
Gorasp2^{tm1a(EUCOMM)Hmgu}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors, ES Cells
Gorasp2^{tm1(KOMP)Vlcg}	Reporter-tagged deletion allele (with selection cassette)	ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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