Pard3 | par-3 family cell polarity regulator

GeneMGI:2135608Synonyms: Pard3a, ASIP, +3 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Nervous system Vision/eye Hematopoietic system Mortality/aging

14 No significant impact

5 Not tested

Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

decreased basophil cell number1 supporting datasetPard3tm1b(KOMP)WtsiheterozygoteEarly adult5.64x10-6 
abnormal optic disk morphology1 supporting datasetPard3tm1b(KOMP)WtsiheterozygoteEarly adult8.03x10-6 
abnormal retina morphology1 supporting datasetPard3tm1b(KOMP)WtsiheterozygoteEarly adult2.47x10-11 
preweaning lethality, complete penetrance1 supporting datasetPard3tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pard3tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Pard3tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Pard3tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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