Gene: Sirt1

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Phenotype System Allele Zyg Sex Life Stage P Value
abnormal tooth morphology Sirt1tm1b(EUCOMM)Wtsi HOM Early adult 3.60×10-06
abnormal iris morphology Sirt1tm1b(EUCOMM)Wtsi HOM Early adult 7.17×10-06
abnormal mean corpuscular hemoglobin concentration Sirt1tm1b(EUCOMM)Wtsi HET Early adult 9.54×10-05
abnormal scapula morphology Sirt1tm1b(EUCOMM)Wtsi HET Early adult 5.86×10-05
abnormal heart left ventricle morphology Sirt1tm1b(EUCOMM)Wtsi HET Early adult 1.61×10-05
abnormal pelvic girdle bone morphology Sirt1tm1b(EUCOMM)Wtsi HET Early adult 4.93×10-05
narrow eye opening Sirt1tm1b(EUCOMM)Wtsi HOM Early adult 1.43×10-05
abnormal snout morphology Sirt1tm1b(EUCOMM)Wtsi HOM Early adult 5.10×10-05
preweaning lethality, incomplete penetrance Sirt1tm1b(EUCOMM)Wtsi HOM Early adult 0.00
abnormal maxilla morphology Sirt1tm1b(EUCOMM)Wtsi HOM Early adult 2.52×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/589) N/A
Aorta 2 No  (1/589) N/A
Bone 2 No N/A
Brain 2 No  (3/589) N/A
Brainstem 2 No  (2/589) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/589) N/A
Cerebral cortex 2 No  (2/589) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (1/589) N/A
Hippocampus 2 No  (3/589) N/A
Hypothalamus 2 No  (2/589) N/A
Kidney 2 No  (20/589)  (1/2)  Wholemount images
Large intestine 2 No  (10/589) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/589) N/A
Lung 2 No  (1/589) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/589) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/589) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/589) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (1/589) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/589) N/A
Prostate gland 2 No  (12/589) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/589) N/A
Spinal cord 2 No  (2/589) N/A
Spleen 2 No  (2/589) N/A
Stomach 2 No  (13/589) N/A
Striatum 2 No  (3/589) N/A
Testis 2 No  (5/589) N/A
Thymus 2 No  (1/2)  Wholemount images
Thyroid gland 2 No  (16/589) N/A
Trachea 2 No  (2/589) N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/506) N/A
Ear 1  (1/506) N/A
Embryo 1  (1/507) N/A
Eye 1  (1/506) N/A
Foot 1  (1/506) N/A
Forebrain 1  (1/506) N/A
Forelimb 1  (1/506) N/A
Hand 1  (1/505) N/A
Head 1  (5/506) N/A
Heart 1  (1/506) N/A
Hindbrain 1  (6/506) N/A
Hindlimb 1  (1/505) N/A
Liver 1  (1/506) N/A
Lung 1  (1/502) N/A
Mandibular process 1  (1/506) N/A
Maxillary process 1  (1/506) N/A
Midbrain 1  (1/506) N/A
Oral cavity 1  (1/506) N/A
Skin 1  (1/506) N/A
Tail 1  (1/506) N/A
Tail somite 1  (1/506) N/A

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
13 Images
X-ray: XRay Images Whole Body Dorso Ventral
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
Echo: M-Mode Images
40 Images
Embryo LacZ: LacZ images wholemount
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
6 Images
Adult LacZ: LacZ Images Wholemount
2 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Sirt1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Sirt1tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp) Mice
Sirt1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells