Gene Summary

Name:
protocadherin gamma subfamily C, 3
Synonyms:
Pcdh2,  PC43

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
dilated heart left ventricle Pcdhgc3em1(IMPC)Hmgu HOM Early adult 6.43×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Human diseases caused by Pcdhgc3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Pcdhgc3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cardiomyopathy, Dilated, 1Q
Dilated cardiomyopathy OMIM:609915
Cardiomyopathy, Dilated, 1H
Dilated cardiomyopathy OMIM:604288
Arrhythmogenic Right Ventricular Dysplasia, Familial, 13
Right ventricular dilatation OMIM:615616
Atrial Fibrillation, Familial, 10
Left atrial enlargement, Right ventricular dilatation, Left ventricular hypertrophy OMIM:614022
Arrhythmogenic Right Ventricular Dysplasia, Familial, 14
Right ventricular dilatation OMIM:618920
Coronary Arterial Fistula
Atrial septal defect, Cardiomegaly, Bacterial endocarditis, Patent foramen ovale, Aortic valve st... ORPHA:2041
Idiopathic/Heritable Pulmonary Arterial Hypertension
Right ventricular dilatation ORPHA:422
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 5
Right ventricular dilatation, Right ventricular hypertrophy OMIM:253700
Immunodeficiency 93 And Hypertrophic Cardiomyopathy
Right ventricular dilatation, Hypertrophic cardiomyopathy OMIM:619705
Peripartum Cardiomyopathy
Left atrial enlargement, Myocarditis, Abnormal atrioventricular valve morphology, Left ventricula... ORPHA:563
Intellectual Disability-Hyperkinetic Movement-Truncal Ataxia Syndrome
Right ventricular dilatation ORPHA:369847
Chromosome 6Q24-Q25 Deletion Syndrome
Dysplastic pulmonary valve, Right ventricular dilatation, Mitral valve prolapse, Dysplastic tricu... OMIM:612863
Atrial Septal Defect, Sinus Venosus Type
Right ventricular dilatation, Anomalous pulmonary venous return ORPHA:99105
Interatrial Communication
Atrial septal defect, Sinus venosus atrial septal defect, Primum atrial septal defect, Secundum a... ORPHA:1478
Atrial Septal Defect, Ostium Primum Type
Left atrial enlargement, Right ventricular dilatation, Right atrial enlargement, Left ventricular... ORPHA:99106
Atrial Septal Defect, Coronary Sinus Type
Right ventricular dilatation, Unroofed coronary sinus, Anomalous pulmonary venous return, Right a... ORPHA:99104
Alg9-Cdg
Atrial septal defect, Abnormal left ventricular outflow tract morphology, Pericardial effusion, A... ORPHA:79328
Atrial Septal Defect, Ostium Secundum Type
Abnormal mitral valve morphology, Right ventricular dilatation, Right atrial enlargement ORPHA:99103
Chronic Thromboembolic Pulmonary Hypertension
Right ventricular dilatation, Right atrial enlargement ORPHA:70591
Viss Syndrome
Atrial septal defect, Patent foramen ovale, Coronary sinus enlargement, Right ventricular hypertr... OMIM:619472
Cutis Laxa, Autosomal Recessive, Type Ib
Right ventricular dilatation OMIM:614437

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pcdhgc3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pcdhgc3.

No publications found that use IMPC mice or data for Pcdhgc3.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Pcdhgc3em1(IMPC)Hmgu Inter-exon deletion Mice

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