Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

chemokine (C-X-C motif) receptor 6

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cxcr6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cxcr6 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Medulloblastoma OMIM:155255
Rhabdoid Tumor Predisposition Syndrome 1
Choroid plexus carcinoma, Medulloblastoma OMIM:609322
Glioma Susceptibility 3
Astrocytoma, Medulloblastoma, Glioblastoma multiforme OMIM:613029
Pleuropulmonary Blastoma
Medulloblastoma, Rhabdomyosarcoma, Pleuropulmonary blastoma OMIM:601200
Glioma Susceptibility 1
Ependymoma, Astrocytoma, Glioblastoma multiforme OMIM:137800
Meningioma, Familial, Susceptibility To
Meningioma OMIM:607174
Schwannomatosis 2
Spinal cord tumor, Schwannoma OMIM:615670
Melanoma-Astrocytoma Syndrome
Cutaneous melanoma, Astrocytoma OMIM:155755
Schwannomatosis 1
Spinal cord tumor, Schwannoma, Meningioma OMIM:162091
Prostate Cancer/Brain Cancer Susceptibility
Prostate cancer, Neoplasm of the central nervous system OMIM:603688
Li-Fraumeni Syndrome
Ovarian neoplasm, Acute lymphoblastic leukemia, Astrocytoma, Thyroid carcinoma, Choriocarcinoma, ... ORPHA:524
Mismatch Repair Cancer Syndrome 1
Neuroblastoma, Astrocytoma, Plexiform neurofibroma, Adenocarcinoma of the small intestine, Adenom... OMIM:276300
Rhabdoid Tumor Predisposition Syndrome 2
Neoplasm of the central nervous system, Carcinoma OMIM:613325
Glioma Susceptibility 9
Leukemia, Glioma, Astrocytoma OMIM:616568
Neuroblastoma, Susceptibility To, 2
Neuroblastoma, Ganglioneuroma, Ganglioneuroblastoma OMIM:613013
Li-Fraumeni Syndrome 2
Meningioma, Stomach cancer, Breast carcinoma, Sarcoma, Glioma OMIM:609265
Familial Multinodular Goiter
Colorectal polyposis, Ovarian neoplasm, Testicular seminoma, Thyroid carcinoma, Sertoli cell neop... ORPHA:276399
Apc-Related Attenuated Familial Adenomatous Polyposis
Astrocytoma, Adenomatous colonic polyposis, Multiple gastric polyps, Papillary thyroid carcinoma,... ORPHA:247806
Gardner Syndrome
Astrocytoma, Adenomatous colonic polyposis, Small intestine carcinoid, Brain neoplasm, Papillary ... ORPHA:79665
Nut Midline Carcinoma
Neuroblastoma, Pancreatic squamous cell carcinoma, Leukemia, Oropharyngeal squamous cell carcinom... ORPHA:443167
Familial Adenomatous Polyposis 1
Adrenocortical carcinoma, Osteoma, Astrocytoma, Adrenocortical adenoma, Adenomatous colonic polyp... OMIM:175100
Polymerase Proofreading-Related Adenomatous Polyposis
Colorectal polyposis, Neoplasm of the rectum, Adenomatous colonic polyposis, Endometrial carcinom... ORPHA:447877
Ovarian neoplasm, Neoplasm of the lung, Neoplasm of the breast, Ependymoma, Neoplasm of the liver... ORPHA:251636
Ovarian neoplasm, Neoplasm of the lung, Neoplasm of the breast, Ependymoma, Neoplasm of the liver... ORPHA:251639
Turcot Syndrome With Polyposis
Astrocytoma, Thyroid carcinoma, Adenomatous colonic polyposis, Leukemia, Brain neoplasm, Basal ce... ORPHA:99818
Familial Adenomatous Polyposis
Neoplasm of the gallbladder, Astrocytoma, Neoplasm of the adrenal gland, Cholangiocarcinoma, Aden... ORPHA:733
Fanconi Anemia, Complementation Group N
Neuroblastoma, Nephroblastoma, Medulloblastoma OMIM:610832
Cutaneous Neuroendocrine Carcinoma
Multiple myeloma, Lymphoid leukemia, Brain neoplasm, Basal cell carcinoma, Squamous cell carcinom... ORPHA:79140
Neuroblastoma, Neoplasm of the lung, Adenomatous colonic polyposis, Spinal cord tumor, Cerebellar... ORPHA:616
Ondine Syndrome
Neuroblastoma, Neoplasm of the central nervous system, Ganglioneuroma, Ganglioneuroblastoma ORPHA:661
Blue Rubber Bleb Nevus
Hemangioma, Cerebellar medulloblastoma OMIM:112200
Familial Multiple Lipomatosis
Odontogenic keratocysts of the jaw, Medulloblastoma ORPHA:199276
Punctate Palmoplantar Keratoderma Type 1
Neoplasm of the lung, Esophageal neoplasm, Stomach cancer, Adenocarcinoma of the small intestine,... ORPHA:79501
Platelet Disorder, Undefined
Neuroblastoma, Hematological neoplasm OMIM:173420
Basal Cell Nevus Syndrome
Cardiac rhabdomyoma, Rhabdomyoma, Odontogenic keratocysts of the jaw, Basal cell carcinoma, Hamar... OMIM:109400
Monosomy 9Q22.3
Odontogenic keratocysts of the jaw, Rhabdomyosarcoma, Basal cell carcinoma, Cardiac fibroma, Ovar... ORPHA:77301
Neurofibromatosis, Type Iii, Mixed Central And Peripheral
Meningioma, Lisch nodules, Palmar neurofibromas, Bilateral vestibular Schwannoma, Paraspinal neur... OMIM:162260
Paragangliomas 7
Pheochromocytoma, Paraganglioma OMIM:618475
Nijmegen Breakage Syndrome
Lymphoma, Glioma, Medulloblastoma, Rhabdomyosarcoma OMIM:251260
Paragangliomas 4
Adrenal pheochromocytoma, Neuroblastoma, Extraadrenal pheochromocytoma, Gastrointestinal stroma t... OMIM:115310
Platelet Disorder, Familial, With Associated Myeloid Malignancy
Neuroblastoma, Myelodysplasia, Lymphoma, Acute myeloid leukemia, Acute monocytic leukemia OMIM:601399
Hirschsprung Disease-Ganglioneuroblastoma Syndrome
Neoplasm of the nervous system, Ganglioneuroblastoma ORPHA:2151
Neurofibromatosis, Type Iv, Of Riccardi
Lisch nodules, Atypical neurofibromatosis OMIM:162270
Bohring-Opitz Syndrome
Nephroblastoma, Medulloblastoma ORPHA:97297
Familial Colorectal Cancer Type X
Neuroblastoma, Neoplasm of the rectum, Stomach cancer, Hepatocellular carcinoma, Glioblastoma mul... ORPHA:440437
Osteogenic Sarcoma
Osteosarcoma, Retinoblastoma OMIM:259500
Peripheral Primitive Neuroectodermal Tumor
Ovarian neoplasm, Brain neoplasm, Neoplasm of the pancreas, Peripheral primitive neuroectodermal ... ORPHA:370348
Lynch Syndrome
Ovarian neoplasm, Neuroblastoma, Neoplasm of the rectum, Hepatocellular carcinoma, Glioblastoma m... ORPHA:144
Leukemia, Lymphoma, Osteosarcoma, Pinealoma, Retinoblastoma, Ewing sarcoma OMIM:180200
Neuroblastoma, Susceptibility To, 1
Neuroblastoma, Ganglioneuroma, Ganglioneuroblastoma OMIM:256700
17Q11 Microdeletion Syndrome
Pheochromocytoma, Myelodysplasia, Gastrointestinal stroma tumor, Rhabdomyosarcoma, Plexiform neur... ORPHA:97685
Aase-Smith Syndrome I
Congenital neuroblastoma OMIM:147800
Haddad Syndrome
Neuroblastoma, Ganglioneuroma ORPHA:99803
Opsoclonus-Myoclonus Syndrome
Neuroblastoma, Neoplasm of the lung, Neoplasm, Breast carcinoma, Ovarian teratoma, Small cell lun... ORPHA:1183
Central Hypoventilation Syndrome, Congenital, 1
Neuroblastoma, Ganglioneuroma, Ganglioneuroblastoma OMIM:209880
Neurofibromatosis, Type I
Pheochromocytoma, Astrocytoma, Plexiform neurofibroma, Meningioma, Rhabdomyosarcoma, Spinal neuro... OMIM:162200
Rhabdomyosarcoma, Leukemia, Leiomyosarcoma, Lymphoma, Ewing sarcoma, Osteosarcoma, Retinoblastoma... ORPHA:790
Neurofibromatosis-Noonan Syndrome
Neuroblastoma, Plexiform neurofibroma, Optic nerve glioma, Lisch nodules, Neurofibromas OMIM:601321
Steinert Myotonic Dystrophy
Neoplasm of the skin, Non-medullary thyroid carcinoma, Endometrial carcinoma, Brain neoplasm, Ova... ORPHA:273
Multiple Benign Circumferential Skin Creases On Limbs
Localized neuroblastoma ORPHA:2505
Skin Creases, Congenital Symmetric Circumferential, 1
Localized neuroblastoma OMIM:156610
Noonan Syndrome With Multiple Lentigines
Neuroblastoma, Myelodysplasia, Melanoma ORPHA:500
Neuroblastoma ORPHA:1666
Dubowitz Syndrome
Neuroblastoma, Acute lymphoblastic leukemia, Lymphoma OMIM:223370
Limbic Encephalitis With Nmda Receptor Antibodies
Neuroblastoma, Neoplasm of the lung, Neoplasm of the breast, Hodgkin lymphoma, Neoplasm of the th... ORPHA:217253
Beckwith-Wiedemann Syndrome
Adrenocortical carcinoma, Neuroblastoma, Rhabdomyosarcoma, Gonadoblastoma, Neoplasm, Leiomyosarco... ORPHA:116
Pinealoma, Retinoblastoma ORPHA:251909
Simpson-Golabi-Behmel Syndrome
Hepatoblastoma, Neuroblastoma, Nephroblastoma, Neoplasm ORPHA:373
Trisomy 8P
Neuroblastoma ORPHA:264450
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Ganglioneuroma, Ganglioneuroblastoma ORPHA:293987
1P36 Deletion Syndrome
Neuroblastoma ORPHA:1606
Gabriele-De Vries Syndrome
Neuroblastoma ORPHA:506358
Sotos Syndrome
Neuroblastoma, Astrocytoma, Acute lymphoblastic leukemia, Cholesteatoma, Hemangioma, Neoplasm, Sa... ORPHA:821


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cxcr6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cxcr6.

No publications found that use IMPC mice or data for Cxcr6.

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MGI Allele Allele Type Produced
Cxcr6tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Cxcr6tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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