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Gene: Cd96 MGI:1934368

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Gene Summary

Name:
CD96 antigen
Synonyms:
Tactile,  1700109I12Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased leukocyte cell number Cd96em1(IMPC)Wtsi HOM Early adult 8.40×10-08

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

DSS Histology

Images

6 Images

View images
Legacy Phenotype Associated Images
Cd96em1(IMPC)Wtsi
WT, Male, WTSI
Cd96em1(IMPC)Wtsi
WT, Male, WTSI
Cd96em1(IMPC)Wtsi
WT, Male, WTSI
Cd96em1(IMPC)Wtsi
WT, Male, WTSI
Cd96em1(IMPC)Wtsi
WT, Male, WTSI

View all 30 images

Cd96em1(IMPC)Wtsi
head, snout, abnormal snout morphology, asymmetric snout, malocclusion, HOM, Male, WTSI

Human diseases caused by Cd96 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Cd96 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
C Syndrome
Midline facial capillary hemangioma ORPHA:1308
C Syndrome
OMIM:211750

The table below shows human diseases predicted to be associated to Cd96 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Myeloproliferative Syndrome, Transient
Leukocytosis, Transient myeloproliferative syndrome OMIM:159595
Wiskott-Aldrich Syndrome 2
Reduced natural killer cell activity, Defective T cell proliferation, Eczematoid dermatitis OMIM:614493
Neutrophil Immunodeficiency Syndrome
Abnormality of neutrophil physiology, Leukocytosis ORPHA:183707
Severe Combined Immunodeficiency, X-Linked
Pneumonia, Decreased circulating IgG level, Recurrent pneumonia, Decreased circulating IgE, Decre... OMIM:300400
Immunodeficiency 14B, Autosomal Recessive
Decreased circulating IgG level, Inflammation of the large intestine, Recurrent pneumonia, Decrea... OMIM:619281
Immunodeficiency 20
Recurrent otitis media, Reduced natural killer cell activity, Recurrent sinusitis OMIM:615707
Inflammatory Bowel Disease (Infantile Ulcerative Colitis) 31, Autosomal Recessive
Anemia, Leukocytosis OMIM:619398
Immunodeficiency 81
Skin rash, Impaired neutrophil chemotaxis, Reduced antigen-specific T cell proliferation, Reduced... OMIM:619374
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Colitis, Decreased circulating antibody level, Abnormal natural killer cell physiology, Recurrent... OMIM:613101
Lymphoproliferative Syndrome, X-Linked, 1
Decreased circulating IgG level, Lymphoma, Decreased circulating antibody level, Infectious encep... OMIM:308240
Eosinophilia, Familial
Anemia, Eosinophilia, Leukocytosis, Thrombocytopenia OMIM:131400
Autoimmune Lymphoproliferative Syndrome, Type Iii
Recurrent otitis media, Recurrent sinusitis, Increased circulating antibody level, Membranous nep... OMIM:615559
Hemophagocytic Lymphohistiocytosis, Familial, 3
Reduced natural killer cell activity OMIM:608898
Juvenile Temporal Arteritis
Eosinophilia, Leukocytosis ORPHA:26137
Neutropenia, Severe Congenital, 2, Autosomal Dominant
B lymphocytopenia, Neutropenia, Monocytosis OMIM:613107
Autoinflammation With Infantile Enterocolitis
Reduced natural killer cell activity, Enterocolitis, Skin rash OMIM:616050
Acute Myelomonocytic Leukemia
Anemia, Eosinophilia, Leukocytosis, Thrombocytopenia ORPHA:517
Juvenile Arthritis
Leukocytosis, Thrombocytosis OMIM:618795
Chronic Myeloid Leukemia
Abnormal granulocyte morphology, Leukocytosis, Splenomegaly, Abnormal basophil morphology, Thromb... ORPHA:521
Ectodermal Dysplasia And Immunodeficiency 1
Abnormal circulating IgG level, Dysgammaglobulinemia, Increased circulating IgA level, Reduced na... OMIM:300291
Immunodeficiency 69
Hemophagocytosis, Hepatosplenomegaly, Pancytopenia, Leukocytosis, Splenomegaly, Thrombocytosis, A... OMIM:618963
Familial Hemophagocytic Lymphohistiocytosis
Decreased circulating antibody level, Skin rash, Infectious encephalitis, Erythroderma, Reduced n... ORPHA:540
Thrombocytopenia 2
Abnormal platelet shape, Abnormal platelet volume, Leukocytosis, Thrombocytopenia OMIM:188000
Acquired Idiopathic Sideroblastic Anemia
Normocytic anemia, Megaloblastic erythroid hyperplasia, Hypochromic anemia, Pancytopenia, Erythro... ORPHA:75564
Polycythemia Vera
Increased hematocrit, Leukocytosis, Splenomegaly, Increased red blood cell mass, Increased circul... OMIM:263300
Wiskott-Aldrich Syndrome
Inflammation of the large intestine, Recurrent pneumonia, Decreased specific anti-polysaccharide ... OMIM:301000
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Abnormally low T cell receptor excision circle level, Reduction of neutrophil motility, Rectal ab... OMIM:608203
Hemophagocytic Lymphohistiocytosis, Familial, 2
Reduced natural killer cell activity, Skin rash, Infectious encephalitis OMIM:603553
Hermansky-Pudlak Syndrome 2
Recurrent pneumonia, Periodontitis, Recurrent otitis media, Impaired ADP-induced platelet aggrega... OMIM:608233
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Leukocytosis, Reticulocytosis, Splenomegaly, Anisocytosis, Heinz bodies, Fava bean-induced hemoly... OMIM:300908
C Syndrome
Midline facial capillary hemangioma ORPHA:1308
C Syndrome
OMIM:211750

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd96

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd96.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Cd96em1(IMPC)Wtsi PMC7263671
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Cd96em1(IMPC)Wtsi PMC6671969

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cd96tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Cd96tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cd96em1(IMPC)Wtsi Deletion Mice

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