Setdb1 | SET domain, bifurcated 1

GeneMGI:1934229Synonyms: KMT1E, ESET

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Hematopoietic system Behavior/neurological Skeleton Mortality/aging

16 No significant impact

3 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance2 supporting datasetsSetdb1tm1a(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased startle reflex1 supporting datasetSetdb1tm1a(EUCOMM)WtsiheterozygoteEarly adult7.84x10-14 
increased CD4-positive, alpha-beta T cell number1 supporting datasetSetdb1tm1a(EUCOMM)WtsiheterozygoteEarly adult6.09x10-7 
increased bone mineral density1 supporting datasetSetdb1tm1a(EUCOMM)WtsiheterozygoteEarly adult1.38x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Setdb1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse

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