The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nrg4.
There are 3 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment.||Cell metabolism (August 2022)||Nrg4tm1c(EUCOMM)Hmgu Nrg4tm1a(EUCOMM)Hmgu||35973424|
|A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.||G3 (Bethesda, Md.) (June 2020)||Nrg4em1(IMPC)Wtsi||PMC7263671|
|Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature.||Biochemical and biophysical research communications (June 2018)||Nrg4tm1c(EUCOMM)Hmgu Nrg4tm1a(EUCOMM)Hmgu||29902456|
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|MGI Allele||Allele Type||Produced|
|Nrg4tm1e(EUCOMM)Hmgu||Targeted, non-conditional allele||ES Cells|
|Nrg4tm1a(EUCOMM)Hmgu||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|