Gene: Nedd4l

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Name
neural precursor cell expressed, developmentally down-regulated gene 4-like
MGI ID
MGI:1933754
Synonyms
Nedd4-2 1300012C07Rik Nedd4b
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Nedd4ltm1b(KOMP)Wtsi HOM   Early adult 0.00
abnormal auditory brainstem response Nedd4ltm1b(KOMP)Wtsi HOM   Early adult 3.57×10-08
abnormal startle reflex Nedd4ltm1b(KOMP)Wtsi HOM Early adult 1.23×10-12
hypoactivity Nedd4ltm1b(KOMP)Wtsi HOM   Early adult 7.35×10-06
abnormal retina morphology Nedd4ltm1b(KOMP)Wtsi HOM Early adult 6.59×10-11
decreased prepulse inhibition Nedd4ltm1b(KOMP)Wtsi HOM Early adult 5.32×10-10
increased anxiety-related response Nedd4ltm1b(KOMP)Wtsi HOM   Early adult 4.33×10-06
decreased startle reflex Nedd4ltm1b(KOMP)Wtsi HOM Early adult 1.04×10-29

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590) N/A
Bone 2 No N/A
Brain 2 No  (3/590)  (2/2)  Wholemount images
Brainstem 2 No  (2/590)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590) N/A
Cerebral cortex 2 No  (2/590) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (1/590) N/A
Hippocampus 2 No  (3/590)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/590) N/A
Kidney 2 No  (20/590) N/A
Large intestine 2 No  (10/590) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/590) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/590) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/590) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/590) N/A
Spinal cord 2 No  (2/590) N/A
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590) N/A
Striatum 2 No  (3/590) N/A
Testis 2 No  (5/590) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Trachea 2 No  (2/590) N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/506) N/A
Ear 1  (1/506) N/A
Embryo 1  (1/507) N/A
Eye 1  (1/506) N/A
Foot 1  (1/506) N/A
Forebrain 1  (1/506) N/A
Forelimb 1  (1/506) N/A
Hand 1  (1/506) N/A
Head 1  (5/506) N/A
Heart 1  (1/506) N/A
Hindbrain 1  (6/506) N/A
Hindlimb 1  (1/506) N/A
Liver 1  (1/504) N/A
Lung 1  (1/504) N/A
Mandibular process 1  (1/506) N/A
Maxillary process 1  (1/506) N/A
Midbrain 1  (1/506) N/A
Oral cavity 1  (1/504) N/A
Skin 1  (1/506) N/A
Tail 1  (1/506) N/A
Tail somite 1  (1/506) N/A

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
16 Images
Echo: M-Mode Images
36 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
X-ray: XRay Images Whole Body Lateral Orientation
16 Images
Embryo LacZ: LacZ images wholemount
8 Images
Adult LacZ: LacZ Images Wholemount
3 Images
Immunophenotyping: Panel A FCS file(s)
7 Images
Immunophenotyping: Panel B FCS file(s)
7 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
5 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Nedd4ltm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Nedd4ltm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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