Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Fc receptor-like S, scavenger receptor
moFcRH2sc,  2810439C17Rik,  Msr2,  IFGP2,  Fcrh2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fcrls mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Fcrls by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Bardet-Biedl Syndrome 14
Obesity OMIM:615991
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Obesity, Increased waist to hip ratio OMIM:601665
Maturity-Onset Diabetes Of The Young, Type 11
Obesity, Overweight OMIM:613375
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Truncal obesity, Large for gestational age OMIM:240900
Immunodeficiency 17
Failure to thrive, Decreased proportion of CD8-positive T cells, Autoimmune hemolytic anemia OMIM:615607
Intellectual Developmental Disorder, Autosomal Dominant 39
Obesity OMIM:616521
Macrosomia With Microphthalmia, Lethal
Large for gestational age OMIM:248110
Prader-Willi Syndrome (Type 2)
Truncal obesity DECIPHER:53
Prader-Willi syndrome (Type 1)
Truncal obesity DECIPHER:14
Immunodeficiency 15A
Decreased proportion of memory B cells, Decreased proportion of CD4-positive helper T cells, Decr... OMIM:618204
Acromegaloid Facial Appearance Syndrome
Large for gestational age OMIM:102150
Mental Retardation, Truncal Obesity, Retinal Dystrophy, And Micropenis Syndrome
Childhood-onset truncal obesity, Truncal obesity OMIM:610156
Abdominal Obesity-Metabolic Syndrome 1
Abdominal obesity OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Abdominal obesity OMIM:605572
Bardet-Biedl Syndrome 11
Obesity OMIM:615988
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Obesity ORPHA:1078
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Large for gestational age ORPHA:356996
Macrosomia Adiposa Congenita
Obesity, Eosinophilia, Large for gestational age OMIM:248100
Bardet-Biedl Syndrome 12
Obesity OMIM:615989
Bardet-Biedl Syndrome 13
Obesity OMIM:615990
Combined Immunodeficiency, X-Linked
Decreased proportion of CD4-positive helper T cells, Decreased proportion of CD8-positive T cells OMIM:312863
Prader-Willi Habitus, Osteopenia, And Camptodactyly
Obesity, Joint contracture of the hand, Camptodactyly OMIM:264010
Intellectual Developmental Disorder, X-Linked 97
Obesity OMIM:300803
Hyperinsulinemic Hypoglycemia, Familial, 1
Large for gestational age OMIM:256450
Hyperinsulinemic Hypoglycemia, Familial, 2
Large for gestational age OMIM:601820
Narcolepsy Type 1
Obesity ORPHA:2073
Summitt Syndrome
Obesity OMIM:272350
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Truncal obesity, Large for gestational age ORPHA:293964
Pituitary Hormone Deficiency, Combined Or Isolated, 7
Abdominal obesity, Truncal obesity OMIM:618160
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Failure to thrive in infancy, Small for gestational age, Hypoplasia of the thymus, Decreased prop... OMIM:617241
Bardet-Biedl Syndrome 18
Obesity OMIM:615995
Wiskott-Aldrich Syndrome 2
Thrombocytopenia, Decreased proportion of CD8-positive T cells OMIM:614493
Obesity Due To Melanocortin 4 Receptor Deficiency
Increased adipose tissue, Obesity, Childhood-onset truncal obesity ORPHA:71529
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type
Obesity OMIM:309585
Mitochondrial Complex Iv Deficiency, Nuclear Type 14
Obesity OMIM:619058
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Neutropenia, Failure to thrive, Decreased proportion of CD3-positive T cells, Hepatosplenomegaly,... ORPHA:169154
Severe Intellectual Disability-Hypotonia-Strabismus-Coarse Face-Planovalgus Syndrome
Obesity ORPHA:436141
Bardet-Biedl Syndrome 10
Obesity OMIM:615987
Adiposis Dolorosa
Obesity, Painful subcutaneous lipomas OMIM:103200
Cd8 Deficiency, Familial
Absence of CD8-positive T cells OMIM:608957
Bardet-Biedl Syndrome 6
Obesity OMIM:605231
Cortisone Reductase Deficiency 2
Obesity OMIM:614662
Body Mass Index Quantitative Trait Locus 20
Obesity, Tall stature OMIM:618406
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity ORPHA:2206
Carcinoma Of Esophagus
Obesity, Weight loss ORPHA:70482
Adenocarcinoma Of The Esophagus
Obesity ORPHA:99976
Bardet-Biedl Syndrome 5
Obesity OMIM:615983
Macrosomia-Microphthalmia-Cleft Palate Syndrome
Large for gestational age ORPHA:2432
Syndromic X-Linked Intellectual Disability 7
Obesity ORPHA:85274
Halothane Hepatitis
Obesity, Eosinophilia OMIM:234350
Hernández-Aguirre Negrete Syndrome
Obesity ORPHA:2139
X-Linked Intellectual Disability-Hypogonadism-Ichthyosis-Obesity-Short Stature Syndrome
Hernia of the abdominal wall, Obesity ORPHA:3055
Mental Retardation, X-Linked 91
Obesity OMIM:300577
Microduplication Xp11.22P11.23 Syndrome
Obesity ORPHA:217377
Immunodeficiency 22
Failure to thrive, Panniculitis, Decreased proportion of CD4-positive helper T cells OMIM:615758
Immunodeficiency 61
Obesity OMIM:300310
Autism, Susceptibility To, 18
Overweight, Tall stature OMIM:615032
Bardet-Biedl Syndrome 19
Obesity OMIM:615996
Central Precocious Puberty
Obesity, Overgrowth, Increased body weight ORPHA:759
Hyperostosis Frontalis Interna
Obesity OMIM:144800
Obesity Due To Prohormone Convertase I Deficiency
Increased adipose tissue, Obesity, Childhood-onset truncal obesity, Failure to thrive ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Increased adipose tissue, Obesity, Childhood-onset truncal obesity, Failure to thrive ORPHA:71526
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells
Pancytopenia, Hypersplenism, Decreased helper T cell proportion, Splenomegaly OMIM:183350
Hypothyroidism, Congenital, Nongoitrous, 6
Omphalocele, Increased body mass index, Anemia, Increased body weight OMIM:614450
Lipodystrophy, Familial Partial, Type 6
Lipodystrophy, Abdominal obesity OMIM:615980
Abcd Syndrome
Large for gestational age OMIM:600501
Obesity, Hyperphagia, And Developmental Delay
Obesity OMIM:613886
Cortisone Reductase Deficiency 1
Obesity OMIM:604931
Bardet-Biedl Syndrome 22
Obesity, Large for gestational age OMIM:617119
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy
T lymphocytopenia, Decreased helper T cell proportion OMIM:601705
Combined Immunodeficiency Due To Zap70 Deficiency
Failure to thrive, Absence of CD8-positive T cells, Hepatosplenomegaly, Lymphocytosis, Autoimmune... ORPHA:911
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
11P15.4 Microduplication Syndrome
Obesity ORPHA:300305
Polycystic Ovary Syndrome 1
Obesity OMIM:184700
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity ORPHA:329249
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity ORPHA:88643
Immunodeficiency, Ovarian Dysgenesis, And Pulmonary Fibrosis
Decreased proportion of CD4-positive helper T cells, Decreased proportion of CD8-positive T cells OMIM:611926
Hepatic Veno-Occlusive Disease
Increased body weight ORPHA:890
Obesity-Hypoventilation Syndrome
Obesity OMIM:257500
Hypothyroidism, Central, With Testicular Enlargement
Overweight OMIM:300888
Nephronophthisis 15
Obesity OMIM:614845
Macrocephaly/Autism Syndrome
Obesity, Lymphopenia, Splenomegaly OMIM:605309
Bardet-Biedl Syndrome 7
Obesity OMIM:615984
Retinal Dystrophy And Obesity
Obesity OMIM:616188
Trisomy 5P
Obesity ORPHA:1742
Short Stature-Obesity Syndrome
Obesity OMIM:269870
Peripheral Neuropathy, Autosomal Recessive, With Or Without Impaired Intellectual Development
Obesity OMIM:618124
Biemond Syndrome Type 2
Obesity ORPHA:141333
Intellectual Developmental Disorder With Behavioral Abnormalities And Craniofacial Dysmorphism With Or Without Seizures
Obesity OMIM:618725
Body Mass Index Quantitative Trait Locus 19
Obesity OMIM:617885
Bardet-Biedl Syndrome 4
Obesity OMIM:615982
Chromosome Xq21 Deletion Syndrome
Obesity OMIM:303110
Bardet-Biedl Syndrome 8
Obesity OMIM:615985
Morbid Obesity And Spermatogenic Failure
Obesity OMIM:615703
Intellectual Developmental Disorder, X-Linked, Syndromic 11
Obesity OMIM:300238
Summitt Syndrome
Obesity, Camptodactyly of finger, Tall stature ORPHA:3210
Leptin Deficiency Or Dysfunction
Obesity OMIM:614962
Spastic Paraplegia-Intellectual Disability-Nystagmus-Obesity Syndrome
Obesity ORPHA:521390
Coenzyme Q10 Deficiency, Primary, 2
Obesity OMIM:614651
Progressive Multifocal Leukoencephalopathy
Decreased proportion of CD8-positive T cells, Abnormal proportion of CD4-positive T cells ORPHA:217260
Immunodeficiency 13
B lymphocytopenia, Decreased proportion of CD4-positive helper T cells, Lymphopenia, Decreased CD... OMIM:615518
Cleft Lip/Palate With Characteristic Facies, Intestinal Malrotation, And Lethal Congenital Heart Disease
Large for gestational age OMIM:601165
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Omphalocele, Overgrowth, Small for gestational age, Large for gestational age, Umbilical hernia ORPHA:254534
Joubert Syndrome 32
Large for gestational age, Tall stature OMIM:617757
Bardet-Biedl Syndrome 2
Obesity OMIM:615981
Mental Retardation, Obesity, Mandibular Prognathism, And Eye And Skin Anomalies
Obesity OMIM:606772
Obesity Due To Sim1 Deficiency
Obesity ORPHA:369873
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Increased body weight ORPHA:276608
Narcolepsy 7
Obesity OMIM:614250
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Obesity OMIM:609734
Bardet-Biedl Syndrome 21
Obesity, Overweight OMIM:617406
Hypogonadism-Mitral Valve Prolapse-Intellectual Disability Syndrome
Obesity ORPHA:2233
Selective Igm Deficiency
Neutropenia in presence of anti-neutropil antibodies, Fasciitis, Decreased proportion of transiti... ORPHA:331235
Obesity ORPHA:79445
Ataxia-Oculomotor Apraxia Type 4
Obesity ORPHA:459033
X-Linked Intellectual Disability, Shashi Type
Obesity ORPHA:85286
Pseudohypoparathyroidism, Type Ib
Obesity OMIM:603233
Immunodeficiency 85 And Autoimmunity
Failure to thrive in infancy, Reduced natural killer cell count, Decreased proportion of CD4-posi... OMIM:619510
Hydrocephalus-Obesity-Hypogonadism Syndrome
Obesity ORPHA:2183
Obesity, Enamel hypoplasia OMIM:612463
Encephalomyopathy, Mitochondrial, Due To Voltage-Dependent Anion Channel Deficiency
Neutropenia, Failure to thrive, Anemia, Large for gestational age, Thrombocytopenia, Umbilical he... OMIM:614520
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia
Obesity OMIM:610628
Atkin-Flaitz Syndrome
Obesity ORPHA:1193
Bardet-Biedl Syndrome 3
Obesity OMIM:600151
Acth-Independent Macronodular Adrenal Hyperplasia 2
Abdominal obesity, Increased body weight OMIM:615954
Myopathy, Congenital, With Respiratory Insufficiency And Bone Fractures
Obesity OMIM:618822
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
Hypereosinophilia, Decreased proportion of CD4-positive helper T cells, Decreased proportion of C... ORPHA:508533
Coloboma-Obesity-Hypogenitalism-Mental Retardation Syndrome
Obesity OMIM:601794
X-Linked Intellectual Disability, Stevenson Type
Obesity, Tall stature ORPHA:85325
Overgrowth-Macrocephaly-Facial Dysmorphism Syndrome
Overgrowth, Large for gestational age, Tall stature ORPHA:137634
Colobomatous Microphthalmia-Obesity-Hypogenitalism-Intellectual Disability Syndrome
Obesity ORPHA:363741
Pigmented Nodular Adrenocortical Disease, Primary, 4
Dorsocervical fat pad, Increased body weight OMIM:615830
Short-Rib Thoracic Dysplasia 11 With Or Without Polydactyly
Obesity OMIM:615633
Blue Diaper Syndrome
Increased body weight ORPHA:94086
Idiopathic Neonatal Atrial Flutter
Large for gestational age ORPHA:45452
Wilson Disease
Failure to thrive, Weight loss, Anemia, Splenomegaly, Thrombocytopenia, Increased body weight ORPHA:905
Chromosome 3Q29 Duplication Syndrome
Obesity OMIM:611936
Leptin Receptor Deficiency
Obesity OMIM:614963
Abdominal Obesity-Metabolic Syndrome 3
Abdominal obesity, Truncal obesity OMIM:615812
Wiskott-Aldrich Syndrome
Absent microvilli on the surface of peripheral blood lymphocytes, Impaired lymphocyte transformat... OMIM:301000
Proprotein Convertase 1/3 Deficiency
Obesity OMIM:600955
Bardet-Biedl Syndrome 9
Obesity, Truncal obesity OMIM:615986
Carpenter Syndrome
Obesity, Polysplenia, Umbilical hernia ORPHA:65759
Obesity Due To Congenital Leptin Deficiency
Obesity, Decreased proportion of CD4-positive helper T cells ORPHA:66628
Obesity Due To Leptin Receptor Gene Deficiency
Obesity, Decreased proportion of CD4-positive helper T cells ORPHA:179494
Senior-Loken Syndrome 9
Obesity OMIM:616629
Male Pseudohermaphroditism/Mental Retardation Syndrome, Verloes Type
Obesity OMIM:600122
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Male Hypergonadotropic Hypogonadism-Intellectual Disability-Skeletal Anomalies Syndrome
Obesity, Eunuchoid habitus ORPHA:2234
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Mitochondrial Dna Depletion Syndrome 12B (Cardiomyopathic Type), Autosomal Recessive
Obesity, Achilles tendon contracture OMIM:615418
Smith-Magenis Syndrome
Increased body weight OMIM:182290
Abnormal CD4:CD8 ratio, Neutropenia, Abnormal proportion of CD8-positive T cells, Leukopenia, Neu... ORPHA:443811
Familial Primary Hypomagnesemia With Normocalciuria And Normocalcemia
Obesity ORPHA:34527
Abdominal Obesity-Metabolic Syndrome 4
Obesity, Elevated hemoglobin A1c OMIM:618620
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome
Obesity OMIM:194072
Congenital Analbuminemia
Obesity, Lipodystrophy, Small for gestational age ORPHA:86816
Hyperinsulinism Due To Hnf4A Deficiency
Increased body weight, Large for gestational age ORPHA:263455
Increased body weight ORPHA:97279
Perrault Syndrome 4
Disproportionate tall stature, Obesity OMIM:615300
Aregenerative Anemia
Neutropenia, Abnormal proportion of CD8-positive T cells, Erythroid hypoplasia, Decreased proport... ORPHA:101096
Low Phospholipid-Associated Cholelithiasis
Liver abscess, Obesity, Overweight ORPHA:69663
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Large for gestational age OMIM:616026
Joubert Syndrome 8
Obesity OMIM:612291
Primary Pigmented Nodular Adrenocortical Disease
Dorsocervical fat pad, Abnormal subcutaneous fat tissue distribution, Abdominal obesity, Increase... ORPHA:189439
Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
Dorsocervical fat pad, Abdominal obesity, Increased body weight ORPHA:189427
Obesity, Elevated hemoglobin A1c, Large for gestational age, Overweight ORPHA:552
Joubert Syndrome 39
Joint contracture of the 5th finger, Overweight OMIM:619562
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Failure to thrive, Anemia, Increased body weight, Splenomegaly, Abnormal erythrocyte enzyme level ORPHA:264580
Bloom Syndrome
Acute lymphoblastic leukemia, Abnormal proportion of CD8-positive T cells, Small for gestational ... ORPHA:125
Hellp Syndrome
Microangiopathic hemolytic anemia, Increased body weight, Thrombocytopenia, Hemolytic anemia, Dec... ORPHA:244242
Adrenocortical Carcinoma
Weight loss, Increased body weight ORPHA:1501
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Anemia, Increased body weight, Splenomegaly ORPHA:79240
Insulin-Resistance Syndrome Type B
Abnormality of body weight, Leukopenia, Weight loss, Thrombocytopenia, Decreased body weight, Inc... ORPHA:2298
Autoimmune Lymphoproliferative Syndrome
Increased B cell count, Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory ... ORPHA:3261
Magel2-Related Prader-Willi-Like Syndrome
Failure to thrive, Increased body weight, Flexion contracture, Abdominal obesity ORPHA:398069
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Obesity ORPHA:209902
Cushing Disease
Leukocytosis, Dorsocervical fat pad, Truncal obesity, Abdominal obesity, Lymphopenia, Decreased e... ORPHA:96253
Gaisböck Syndrome
Increased red blood cell count, Elevated plasma cell count, Increased mean corpuscular hemoglobin... ORPHA:90041
Cushing Syndrome Due To Ectopic Acth Secretion
Leukocytosis, Weight loss, Dorsocervical fat pad, Truncal obesity, Abdominal obesity, Lymphopenia... ORPHA:99889
Carney Complex
Dorsocervical fat pad, Abdominal obesity, Increased body weight, Tall stature ORPHA:1359


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fcrls

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fcrls.

No publications found that use IMPC mice or data for Fcrls.

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MGI Allele Allele Type Produced
Fcrlsem1(IMPC)H Inter-exon deletion Mice
Fcrlsem2(IMPC)H Inter-exon deletion Mice
Fcrlsem3(IMPC)H Inter-exon deletion Mice
Fcrlstm271021(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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