Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

synaptotagmin-like 2
Slp2-c,  Slp2,  Slp2-b,  Slp2-a,  Slp2-d

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sytl2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Sytl2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Polyposis of gastric fundus without polyposis coli
Abnormal gastric mucosa morphology, Multiple gastric polyps OMIM:175505
Polyposis, gastric
Multiple gastric polyps OMIM:175020
Ménétrier Disease
Nausea, Gastrointestinal hemorrhage, Giant hypertrophic gastritis, Helicobacter pylori infection,... ORPHA:2494
Nk-Cell Enteropathy
Hematochezia, Gastric ulcer, Intestinal polyp, Constipation, Gastroesophageal reflux, Colonic div... ORPHA:263665
Inflammatory Bowel Disease (Crohn Disease) 30
Bloody diarrhea, Pancolitis, Chronic diarrhea, Ileitis, Abnormal intestine morphology, Protein-lo... OMIM:619079
Oculogastrointestinal Muscular Dystrophy
Abnormality of the gastrointestinal tract, Gastroparesis, Abnormal gastric mucosa morphology, Mal... ORPHA:1876
Diffuse Gastric And Lobular Breast Cancer Syndrome
Stomach cancer, Atrophic gastritis, Cleft palate OMIM:137215
Pyloric Atresia
Congenital pyloric atresia OMIM:265950
Intrinsic Factor And R Binder, Combined Congenital Deficiency Of
Absence of intrinsic factor OMIM:243320
Pyloric Stenosis, Infantile Hypertrophic, 1
Projectile vomiting, Pyloric stenosis OMIM:179010
Gastric Adenocarcinoma And Proximal Polyposis Of The Stomach
Fundic gland polyposis, Gastric adenocarcinoma, Melena OMIM:619182
Chronic Intestinal Pseudoobstruction
Pyloric stenosis, Intestinal malrotation, Abnormal intestine morphology ORPHA:2978
Cap Polyposis
Colorectal polyposis, Hematochezia, Constipation, Atrophic gastritis, Diarrhea ORPHA:160148
Dubin-Johnson Syndrome
Abnormal gastric mucosa morphology ORPHA:234
Gastritis, Familial Giant Hypertrophic
Giant hypertrophic gastritis OMIM:137280
Esophageal Ring, Lower
Hiatus hernia, Dysphagia OMIM:133240
Reynolds Syndrome
Gastroesophageal reflux, Xerostomia, Dysphagia, Abnormal gastric mucosa morphology ORPHA:779
Immunodeficiency 57 With Autoinflammation
Diarrhea, Gastritis, Perianal abscess, Inflammation of the large intestine OMIM:618108
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Duodenal ulcer, Gastric ulcer, Esophageal ulceration OMIM:618372
Cystic Fibrosis-Gastritis-Megaloblastic Anemia Syndrome
Diarrhea, Gastritis ORPHA:2575
Williams Syndrome
Constipation, Gastroesophageal reflux, Tracheoesophageal fistula, Colonic diverticula, Macrogloss... ORPHA:904
Wolfram Syndrome 2
Gastric ulcer OMIM:604928
Arteriosclerosis, Severe Juvenile
Gastric ulcer OMIM:208060
Wolfram Syndrome
Constipation, Gastric ulcer, Gastrointestinal hemorrhage, Malabsorption ORPHA:3463
Necrotizing Encephalomyelopathy, Subacute, Of Leigh, Adult
Gastric hypertrophy, Gastric ulcer OMIM:161700
Congenital Tracheal Stenosis
Abnormal stomach morphology, Morphological abnormality of the gastrointestinal tract, Tracheoesop... ORPHA:141127
Coffin-Siris Syndrome 1
High palate, Gastric ulcer, Intestinal malrotation, Intussusception, Cleft palate, Duodenal ulcer OMIM:135900
Cystic Fibrosis With Helicobacter Pylori Gastritis, Megaloblastic Anemia, And Mental Retardation
Exocrine pancreatic insufficiency, Meconium ileus, Diarrhea, Gastritis OMIM:219721
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Esophageal varix, Gastric ulcer ORPHA:2072
Immunodeficiency 82 With Systemic Inflammation
Intractable diarrhea, Crohn's disease, Colitis, Villous atrophy, Anoperineal fistula, Diarrhea, G... OMIM:619381


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sytl2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sytl2.

No publications found that use IMPC mice or data for Sytl2.

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MGI Allele Allele Type Produced
Sytl2tm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Sytl2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Sytl2tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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