banner
Genes Phenotypes Help, News, Blog

Gene: Cyp4x1 MGI:1932403

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cytochrome P450, family 4, subfamily x, polypeptide 1
Synonyms:
Cyp4a28-ps

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cyp4x1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cyp4x1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Obesity
Decreased resting energy expenditure, Obesity, Increased waist to hip ratio OMIM:601665
Maturity-Onset Diabetes Of The Young, Type 11
Obesity, Overweight OMIM:613375
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Severe Intellectual Disability-Hypotonia-Strabismus-Coarse Face-Planovalgus Syndrome
Obesity, Gait disturbance ORPHA:436141
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Obesity Due To Melanocortin 4 Receptor Deficiency
Obesity, Childhood-onset truncal obesity, Increased adipose tissue ORPHA:71529
Adiposis Dolorosa
Painful subcutaneous lipomas, Obesity OMIM:103200
Bardet-Biedl Syndrome 11
Obesity OMIM:615988
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Obesity ORPHA:1078
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Large for gestational age, Truncal obesity ORPHA:293964
Bardet-Biedl Syndrome 14
Obesity OMIM:615991
Bardet-Biedl Syndrome 13
Obesity OMIM:615990
Simpson-Golabi-Behmel Syndrome, Type 2
Obesity, Inguinal hernia OMIM:300209
X-Linked Intellectual Disability-Hypogonadism-Ichthyosis-Obesity-Short Stature Syndrome
Hernia of the abdominal wall, Obesity ORPHA:3055
Intellectual Developmental Disorder, X-Linked 97
Obesity OMIM:300803
Hyperinsulinemic Hypoglycemia, Familial, 1
Large for gestational age OMIM:256450
Obesity Due To Prohormone Convertase I Deficiency
Obesity, Childhood-onset truncal obesity, Failure to thrive, Increased adipose tissue ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Obesity, Childhood-onset truncal obesity, Failure to thrive, Increased adipose tissue ORPHA:71526
Hypothyroidism, Congenital, Nongoitrous, 6
Increased body weight, Broad-based gait, Omphalocele, Increased body mass index OMIM:614450
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Large for gestational age, Obesity, Truncal obesity OMIM:240900
Hyperinsulinemic Hypoglycemia, Familial, 2
Large for gestational age OMIM:601820
Autism, Susceptibility To, X-Linked 6
Obesity OMIM:300872
Obesity-Hypoventilation Syndrome
Obesity, Cyanosis OMIM:257500
Body Mass Index Quantitative Trait Locus 20
Tall stature, Obesity OMIM:618406
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity ORPHA:2206
Obesity And Hypopigmentation
Overgrowth, Obesity OMIM:620195
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Increased body weight, Lethargy ORPHA:276608
Bardet-Biedl Syndrome 22
Obesity, Large for gestational age OMIM:617119
Hepatic Veno-Occlusive Disease
Increased body weight ORPHA:890
Global Developmental Delay, Lung Cysts, Overgrowth, And Wilms Tumor
Overgrowth, Large for gestational age, Inguinal hernia, Umbilical hernia OMIM:618272
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity ORPHA:329249
Phip-Related Behavioral Problems-Intellectual Disability-Obesity-Dysmorphic Features Syndrome
Increased body weight, Gait disturbance ORPHA:589905
Joubert Syndrome 32
Tall stature, Large for gestational age, Ataxia OMIM:617757
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity ORPHA:88643
Laurence-Moon Syndrome
Obesity, Ataxia OMIM:245800
Cortisone Reductase Deficiency 2
Obesity OMIM:614662
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Umbilical hernia, Large for gestational age, Overgrowth, Omphalocele, Small for gestational age ORPHA:254534
Autosomal Recessive Emery-Dreifuss Muscular Dystrophy
Tip-toe gait, Elbow flexion contracture, Obesity, Decreased cervical spine flexion due to contrac... ORPHA:98855
Congenital Myopathy 9A
Obesity, Akinesia OMIM:618822
Polycystic Ovary Syndrome 1
Obesity OMIM:184700
Pigmented Nodular Adrenocortical Disease, Primary, 4
Increased body weight, Dorsocervical fat pad OMIM:615830
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Hypothyroidism, Central, With Testicular Enlargement
Overweight OMIM:300888
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Increased body weight, Small for gestational age OMIM:274300
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Increased body weight, Lethargy, Large for gestational age ORPHA:263455
Insulinoma
Increased body weight, Lethargy ORPHA:97279
Hypogonadotropic Hypogonadism 27 Without Anosmia
Obesity OMIM:619755
Congenital Analbuminemia
Obesity, Lipodystrophy, Small for gestational age ORPHA:86816
Wilson Disease
Increased body weight, Difficulty walking, Weight loss, Failure to thrive ORPHA:905
Acth-Independent Macronodular Adrenal Hyperplasia 2
Increased body weight, Abdominal obesity OMIM:615954
Blue Diaper Syndrome
Increased body weight ORPHA:94086
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Smith-Magenis Syndrome
Increased body weight OMIM:182290
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Increased body weight, Dorsocervical fat pad, Abdominal obesity ORPHA:189427
Magel2-Related Prader-Willi-Like Syndrome
Failure to thrive, Increased body weight, Lethargy, Abdominal obesity, Flexion contracture ORPHA:398069
Sotos Syndrome
Increased body weight, Tall stature, Overgrowth OMIM:117550
Joubert Syndrome 39
Overweight, Joint contracture of the 5th finger OMIM:619562
Adrenocortical Carcinoma
Increased body weight, Weight loss ORPHA:1501
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Increased body weight, Failure to thrive ORPHA:264580
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Increased body weight ORPHA:79240
Insulin-Resistance Syndrome Type B
Increased body weight, Abnormality of body weight, Weight loss, Decreased body weight ORPHA:2298
Cushing Disease
Increased body weight, Dorsocervical fat pad, Truncal obesity, Abdominal obesity ORPHA:96253
Hellp Syndrome
Increased body weight ORPHA:244242
Cushing Syndrome Due To Ectopic Acth Secretion
Dorsocervical fat pad, Increased body weight, Weight loss, Truncal obesity, Abdominal obesity ORPHA:99889
Carney Complex
Increased body weight, Tall stature, Dorsocervical fat pad, Abdominal obesity ORPHA:1359

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cyp4x1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cyp4x1.

No publications found that use IMPC mice or data for Cyp4x1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cyp4x1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cyp4x1tm467(L1L2_st0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cyp4x1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter