Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Egln2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Mosaic Variegated Aneuploidy Syndrome 4 | Abnormality of chromosome stability | OMIM:620153 | |
Scleroderma, Familial Progressive | Calcinosis, Chromosome breakage, Abnormality of chromosome stability | OMIM:181750 | |
Oxoglutaric Aciduria | Abnormality of Krebs cycle metabolism, Skeletal muscle atrophy | ORPHA:31 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Egln2.
There are 3 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor. | Oncotarget (January 2017) | Egln2tm1(KOMP)Vlcg | PMC5351669 |
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. | Genes & development (July 2014) | Egln2tm1(KOMP)Vlcg | PMC4083087 |
Treatment of erythropoietin deficiency in mice with systemically administered siRNA. | Blood (May 2012) | Egln2tm1(KOMP)Vlcg | PMC3433093 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Egln2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Egln2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Egln2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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