Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
egl-9 family hypoxia-inducible factor 2
Synonyms:
SM-20,  0610011A13Rik,  Phd1,  Hif-p4h-1,  Ier4

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Egln2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Egln2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Mosaic Variegated Aneuploidy Syndrome 4
Abnormality of chromosome stability OMIM:620153
Scleroderma, Familial Progressive
Chromosome breakage, Abnormality of chromosome stability, Calcinosis OMIM:181750
Oxoglutaric Aciduria
Abnormality of Krebs cycle metabolism, Skeletal muscle atrophy ORPHA:31

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Egln2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Egln2.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor. Oncotarget (January 2017) Egln2tm1(KOMP)Vlcg PMC5351669
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes & development (July 2014) Egln2tm1(KOMP)Vlcg PMC4083087
Treatment of erythropoietin deficiency in mice with systemically administered siRNA. Blood (May 2012) Egln2tm1(KOMP)Vlcg PMC3433093

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Egln2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Egln2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Egln2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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