Gene: Dbn1

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Phenotype System Allele Zyg Sex Life Stage P Value
abnormal heart morphology Dbn1tm1b(KOMP)Wtsi HET Early adult 0.00
decreased circulating HDL cholesterol level Dbn1tm1a(KOMP)Wtsi HOM Early adult 2.01×10-16
increased circulating creatinine level Dbn1tm1b(KOMP)Wtsi HET Early adult 7.76×10-05
preweaning lethality, incomplete penetrance Dbn1tm1a(KOMP)Wtsi HOM Early adult 0.00
decreased circulating total protein level Dbn1tm1a(KOMP)Wtsi HOM Early adult 2.40×10-08
preweaning lethality, complete penetrance Dbn1tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased total body fat amount Dbn1tm1a(KOMP)Wtsi HOM Early adult 1.58×10-23
pallor Dbn1em2(IMPC)Mbp HET E9.5 0.00
decreased circulating LDL cholesterol level Dbn1tm1a(KOMP)Wtsi HOM Early adult 1.14×10-06
decreased circulating calcium level Dbn1tm1a(KOMP)Wtsi HOM Early adult 4.15×10-06
decreased body weight Dbn1tm1a(KOMP)Wtsi HOM Early adult 5.97×10-17
increased lean body mass Dbn1tm1a(KOMP)Wtsi HET Early adult 2.82×10-05
abnormal liver morphology Dbn1tm1b(KOMP)Wtsi HET Early adult 0.00
decreased mean platelet volume Dbn1tm1b(KOMP)Wtsi HET Early adult 3.66×10-05
increased lean body mass Dbn1tm1b(KOMP)Wtsi HET Early adult 1.53×10-05
increased hemoglobin content Dbn1tm1b(KOMP)Wtsi HET Early adult 1.15×10-05
preweaning lethality, incomplete penetrance Dbn1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal retinal inner nuclear layer morphology Dbn1tm1b(KOMP)Wtsi HET Early adult 1.47×10-06
abnormal allantois morphology Dbn1em2(IMPC)Mbp HOM E9.5 0.00
decreased circulating serum albumin level Dbn1tm1a(KOMP)Wtsi HOM Early adult 1.44×10-13
decreased circulating alanine transaminase level Dbn1tm1a(KOMP)Wtsi HOM Early adult 6.56×10-05
decreased circulating fructosamine level Dbn1tm1a(KOMP)Wtsi HOM Early adult 3.94×10-06
decreased mean corpuscular volume Dbn1tm1a(KOMP)Wtsi HOM Early adult 5.59×10-05
abnormal chorioallantoic fusion Dbn1em2(IMPC)Mbp HOM E9.5 0.00
decreased total retina thickness Dbn1tm1b(KOMP)Wtsi HET Early adult 1.25×10-06
abnormal coat appearance Dbn1em1(IMPC)Bay HOM Early adult 6.08×10-06
abnormal embryo size Dbn1em2(IMPC)Mbp HOM E9.5 0.00
increased fluid intake Dbn1tm1b(KOMP)Wtsi HET Early adult 2.18×10-09
improved glucose tolerance Dbn1tm1b(KOMP)Wtsi HET Early adult 5.10×10-05
abnormal embryo turning Dbn1em2(IMPC)Mbp HOM E9.5 0.00
decreased total body fat amount Dbn1tm1a(KOMP)Wtsi HET Early adult 3.99×10-05
decreased circulating cholesterol level Dbn1tm1a(KOMP)Wtsi HOM Early adult 3.24×10-12
abnormal embryo size Dbn1tm1b(KOMP)Wtsi HOM E18.5 0.00
increased circulating chloride level Dbn1tm1a(KOMP)Wtsi HOM Early adult 5.46×10-07
decreased circulating aspartate transaminase level Dbn1tm1a(KOMP)Wtsi HOM Early adult 3.39×10-05
increased food intake Dbn1tm1b(KOMP)Wtsi HET Early adult 5.39×10-05
increased fasting circulating glucose level Dbn1tm1b(KOMP)Wtsi HET Early adult 2.07×10-05
decreased total body fat amount Dbn1tm1b(KOMP)Wtsi HET Early adult 1.15×10-07
decreased caudal vertebrae number Dbn1tm1b(KOMP)Wtsi HET Early adult 4.60×10-07
increased CD8-positive, alpha-beta T cell number Dbn1tm1b(KOMP)Wtsi HET Early adult 0.00
enlarged heart Dbn1tm1b(KOMP)Wtsi HET Early adult 0.00
increased circulating phosphate level Dbn1tm1b(KOMP)Wtsi HET Early adult 4.72×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 24 No  (2/584)  (12/24)  Wholemount images  Section images
Aorta 24 No  (6/24)  Wholemount images  Section images
Blood 8 No N/A
Blood vessel 4 No  (1/4) N/A
Bone 17 No  (5/17)  Wholemount images  Section images
Bone marrow 8 No N/A
Brain 24 No  (22/24)  Wholemount images  Section images
Brainstem 24 No  (15/24)  Wholemount images  Section images
Brown adipose tissue 22 No N/A
Cartilage tissue 24 No  (1/24) N/A
Cecum 14 No  (12/379)  (7/14)  Wholemount images  Section images
Cerebellum 24 No  (20/24)  Wholemount images  Section images
Cerebral cortex 24 No  (16/24)  Wholemount images
Chest bone 12 No  Wholemount images
Colon 12 No  (12/127)  (8/12)  Wholemount images  Section images
Cranium 8 No  (1/8) N/A
Diaphragm 12 No N/A
Duodenum 10 No  (2/127)  (8/10)  Wholemount images  Section images
Epididymis 14 No  (18/134)  (3/14)  Wholemount images  Section images
Esophagus 20 No  (7/415)  (5/20)  Wholemount images
Eye 24 No  (10/24)  Wholemount images  Section images
Gall bladder 20 No  Wholemount images
Gonadal fat pad 10 No N/A
Harderian gland 12 No  Wholemount images
Heart 24 No  Wholemount images
Hindlimb 12 No N/A
Hippocampus 24 No  (16/24)  Wholemount images
Hypothalamus 24 No  (16/24)  Wholemount images
Ileum 10 No  (14/127)  (7/10)  Wholemount images  Section images
Jejunum 10 No  (6/127)  (6/10)  Wholemount images
Kidney 24 No  (18/584)  (18/24)  Wholemount images  Section images
Large intestine 24 No  (10/584)  (16/24)  Wholemount images
Liver 24 No  Wholemount images
Lower urinary tract 24 No  (7/24)  Wholemount images
Lung 24 No  Wholemount images
Lymph node 24 No  Wholemount images
Main olfactory bulb 8 No  (4/8)  Wholemount images
Mammary gland 24 No  (1/24)  Section images
Mesenteric adipose tissue 10 No N/A
Mesenteric lymph node 14 No  Wholemount images
Midbrain 12 No  (10/12)  Wholemount images  Section images
Esophagus 4 No N/A
Olfactory lobe 24 No  (19/24)  Wholemount images  Section images
Oral epithelium 12 No  (1/12) N/A
Ovary 24 No  (1/584)  (7/24)  Wholemount images  Section images
Oviduct 24 No  (8/24)  Wholemount images  Section images
Pancreas 24 No  (5/584)  (3/24)  Wholemount images
Parathyroid gland 20 No  (3/20)  Wholemount images
Parotid gland 12 No  Wholemount images
Penis 12 No  (4/12)  Wholemount images  Section images
Peripheral nervous system 24 No  (15/24)  Wholemount images
Peyer's patch 4 No N/A
Peyer's patch 20 No N/A
Pituitary gland 24 No  (17/24)  Wholemount images  Section images
Prostate gland 24 No  (12/584)  (3/24)  Wholemount images  Section images
Quadriceps 10 No  (1/10)  Section images
Sciatic nerve 12 No  (3/12)  Wholemount images  Section images
Skeletal muscle 20 No N/A
Skeletal muscle tissue 4 No N/A
Skin 24 No  (3/24)  Wholemount images  Section images
Small intestine 24 No  (9/584)  (14/24)  Wholemount images
Spinal cord 24 No  (24/24)  Wholemount images  Section images
Spleen 24 No  (2/584)  Wholemount images
Stomach 24 No  (12/584)  (14/24)  Wholemount images  Section images
Stomach pyloric region 12 No N/A
Striatum 24 No  (16/24)  Wholemount images
Sublingual gland 12 No  (2/12)  Wholemount images  Section images
Submandibular gland 14 No  (2/132)  (1/14)  Wholemount images
Testis 24 No  (2/584)  (10/24)  Wholemount images  Section images
Thalamus 8 No  (6/8) N/A
Thymus 24 No  (1/24)  Wholemount images
Thyroid gland 24 No  (15/584)  (6/24)  Wholemount images
Tongue 12 No  (5/127)  (5/12)  Wholemount images
Trachea 24 No  Wholemount images
Trigeminal V nerve 14 No  (8/14)  Wholemount images  Section images
Urinary bladder 16 No  (6/16)  Wholemount images  Section images
Uterus 24 No  (9/24)  Wholemount images  Section images
Vagina 12 No  Wholemount images
Vas deferens 14 No  (15/388)  (2/14)  Wholemount images  Section images
Vascular system 20 No  (2/20) N/A
Vesicular gland 14 No  (1/14)  Wholemount images  Section images
White adipose tissue 24 No N/A
LacZ Section Images

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View all 13 images

View all 7 images

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 7  (1/57)  (10/11) N/A
Axial skeleton 7  (1/61)  (10/11) N/A
Brain 17  (6/504)  (20/24) N/A
Central nervous system ganglion 4  (1/70)  (3/5) N/A
Cranium 3  (1/61)  (2/4) N/A
Dorsal root ganglion 3  (1/57)  (2/4) N/A
Ear 17  (1/504)  (18/24) N/A
Embryo 17  (1/505)  (22/24)  Wholemount images
Outer ear 3  (1/66)  (2/4) N/A
Eye 17  (1/504)  (21/24)  Wholemount images
Femur pre-cartilage condensation 2  (1/52)  (2/3) N/A
Foot 17  (1/504)  (10/24) N/A
Forearm 7  (1/297)  (6/8) N/A
Forebrain 17  (1/504)  (20/24)  Wholemount images
Forelimb 17  (1/504)  (21/24)  Wholemount images
Fronto-nasal process 7  (1/58)  (9/11) N/A
Gut 3  (1/56)  (3/4) N/A
Hand 17  (1/503)  (10/24) N/A
Head 17  (5/504)  (21/24)  Wholemount images
Head mesenchyme 7  (1/57)  (9/10) N/A
Heart 17  (1/504)  (13/24)  Wholemount images
Heart ventricle 7  (1/57)  (10/11) N/A
Hindbrain 17  (6/504)  (20/24)  Wholemount images
Hindlimb 17  (1/503)  (21/24)  Wholemount images
Humerus pre-cartilage condensation 3  (1/61)  (2/4) N/A
Inner ear 3  (1/61)  (2/4) N/A
Intestine 2  (1/55)  (2/3) N/A
Liver 17  (1/504)  (5/24)  Wholemount images
Lower leg 7  (1/297)  (6/8) N/A
Lung 17  (1/500)  (13/24) N/A
Mandibular process 17  (1/504)  (19/24)  Wholemount images
Maxillary process 17  (1/504)  (19/24)  Wholemount images
Meckel's cartilage 5  (8/8) N/A
Mesonephros of female 2  (1/52)  (2/3) N/A
Mesonephros of male 2  (1/52)  (2/3) N/A
Metanephros 2  (1/52)  (2/3) N/A
Midbrain 17  (1/504)  (20/24)  Wholemount images
Nasal septum 2  (1/57)  (2/3) N/A
Nose 9  (1/70)  (11/13) N/A
Notochord 7  (1/57)  (10/11) N/A
Oral cavity 17  (1/504)  (14/24) N/A
Outflow tract 7  (1/57)  (10/11) N/A
Pancreas 2  (1/52)  (2/3) N/A
Pericardium 3  (1/52)  (3/4) N/A
Pharynx 2  (1/52)  (2/3) N/A
Radius-ulna pre-cartilage condensation 3  (1/61)  (2/4) N/A
Rib pre-cartilage condensation 2  (1/54)  (2/3) N/A
Skeleton 8  (1/70)  (10/12) N/A
Skin 17  (1/504)  (15/24) N/A
Spinal cord 7  (1/69)  (8/10) N/A
Stomach 2  (1/52)  (2/3) N/A
Tail 17  (1/504)  (20/24)  Wholemount images
Tail somite 17  (1/504)  (17/24)  Wholemount images
Thoracic vertebral cartilage condensation 2  (1/52)  (2/3) N/A
Tongue 2  (1/52)  (2/3) N/A
Trachea 3  (1/56)  (3/4) N/A
Trunk mesenchyme 7  (1/57)  (9/11) N/A
Umbilical artery embryonic part 2  (1/57)  (2/3) N/A
Umbilical vein embryonic part 2  (1/57)  (2/3) N/A
Upper arm 7  (1/297)  (6/8) N/A
Upper leg 7  (1/297)  (6/8) N/A
Urinary system 3  (1/56)  (3/4) N/A
Vibrissa 8  (1/66)  (10/12) N/A

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
193 Images
Embryo LacZ: LacZ images wholemount
88 Images
X-ray: XRay Images Forepaw
82 Images
X-ray: XRay Images Skull Lateral Orientation
81 Images
X-ray: XRay Images Whole Body Dorso Ventral
232 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
97 Images
Combined SHIRPA and Dysmorphology
9 Images
Eye Morphology: Images Ophthalmoscopy
10 Images
X-ray: XRay Images Hind Leg and Hip
31 Images
Adult LacZ: LacZ Images Wholemount
246 Images
Legacy Phenotype Associated Images

View all 472 images

View all 13 images

View all 6 images

View all 6 images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Dbn1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Dbn1em1(IMPC)Bay Exon Deletion Mice, Tissue
Dbn1em1(IMPC)J Intra-exon deletion Mice
Dbn1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Dbn1em2(IMPC)Mbp Null reporter Mice, Tissue

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