Gene: Dbn1

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo turning Dbn1em2(IMPC)Mbp HOM embryonic day 9.5 0.00
decreased circulating cholesterol level Dbn1tm1a(KOMP)Wtsi HOM postnatal 3.63×10-11
increased circulating creatinine level Dbn1tm1b(KOMP)Wtsi HET postnatal 6.56×10-05
decreased effector memory CD8-positive, alpha-beta T cell number Dbn1tm1a(KOMP)Wtsi HOM postnatal 8.78×10-05
decreased circulating aspartate transaminase level Dbn1tm1a(KOMP)Wtsi HOM postnatal 1.65×10-05
pallor Dbn1em2(IMPC)Mbp HET embryonic day 9.5 0.00
increased circulating chloride level Dbn1tm1a(KOMP)Wtsi HOM postnatal 8.94×10-08
decreased circulating alanine transaminase level Dbn1tm1a(KOMP)Wtsi HOM postnatal 4.70×10-05
increased lean body mass Dbn1tm1a(KOMP)Wtsi HET postnatal 2.29×10-05
decreased total retina thickness Dbn1tm1b(KOMP)Wtsi HET postnatal 1.27×10-06
thrombocytosis Dbn1tm1a(KOMP)Wtsi HOM postnatal 3.42×10-05
decreased monocyte cell number Dbn1tm1a(KOMP)Wtsi HOM postnatal 7.53×10-05
increased heart weight Dbn1tm1b(KOMP)Wtsi HET postnatal 7.23×10-08
increased food intake Dbn1tm1b(KOMP)Wtsi HET postnatal 5.39×10-05
abnormal coat appearance Dbn1em1(IMPC)Bay HOM postnatal 7.23×10-06
increased lean body mass Dbn1tm1b(KOMP)Wtsi HET postnatal 1.53×10-05
enlarged heart Dbn1tm1b(KOMP)Wtsi HET postnatal 0.00
decreased total body fat amount Dbn1tm1a(KOMP)Wtsi HET postnatal 3.56×10-05
decreased circulating fructosamine level Dbn1tm1a(KOMP)Wtsi HOM postnatal 4.05×10-05
decreased total body fat amount Dbn1tm1b(KOMP)Wtsi HET postnatal 1.15×10-07
abnormal embryo size Dbn1em2(IMPC)Mbp HOM embryonic day 9.5 0.00
preweaning lethality, complete penetrance Dbn1tm1b(KOMP)Wtsi HOM n/a 0.00
decreased circulating LDL cholesterol level Dbn1tm1a(KOMP)Wtsi HOM postnatal 8.61×10-07
preweaning lethality, incomplete penetrance Dbn1tm1a(KOMP)Wtsi HOM n/a 0.00
decreased body weight Dbn1tm1a(KOMP)Wtsi HOM postnatal 2.54×10-16
decreased circulating total protein level Dbn1tm1a(KOMP)Wtsi HOM postnatal 1.35×10-07
decreased circulating HDL cholesterol level Dbn1tm1a(KOMP)Wtsi HOM postnatal 2.04×10-15
increased CD8-positive, alpha-beta T cell number Dbn1tm1b(KOMP)Wtsi HET postnatal 0.00
abnormal vertebrae morphology Dbn1tm1b(KOMP)Wtsi HET postnatal 2.52×10-05
increased circulating phosphate level Dbn1tm1b(KOMP)Wtsi HET postnatal 4.66×10-05
improved glucose tolerance Dbn1tm1b(KOMP)Wtsi HET postnatal 5.10×10-05
decreased total body fat amount Dbn1tm1a(KOMP)Wtsi HOM postnatal 6.22×10-23
decreased mean corpuscular volume Dbn1tm1a(KOMP)Wtsi HOM postnatal 1.74×10-05
preweaning lethality, incomplete penetrance Dbn1tm1b(KOMP)Wtsi HOM n/a 0.00
decreased circulating calcium level Dbn1tm1a(KOMP)Wtsi HOM postnatal 6.19×10-06
abnormal chorioallantoic fusion Dbn1em2(IMPC)Mbp HOM embryonic day 9.5 0.00
increased fluid intake Dbn1tm1b(KOMP)Wtsi HET postnatal 2.18×10-09
decreased mean platelet volume Dbn1tm1b(KOMP)Wtsi HET postnatal 3.58×10-05
abnormal retinal inner nuclear layer morphology Dbn1tm1b(KOMP)Wtsi HET postnatal 1.72×10-06
decreased circulating serum albumin level Dbn1tm1a(KOMP)Wtsi HOM postnatal 2.52×10-12
abnormal sleep behavior Dbn1tm1b(KOMP)Wtsi HET postnatal 2.67×10-06
abnormal embryo size Dbn1tm1b(KOMP)Wtsi HOM embryonic day 18.5 0.00
abnormal allantois morphology Dbn1em2(IMPC)Mbp HOM embryonic day 9.5 0.00
embryonic lethality prior to tooth bud stage Dbn1em2(IMPC)Mbp HOM embryonic day 12.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 22 No  (2/584)  (11/22)  Wholemount images
Aorta 22 No  (6/22)  Wholemount images
Blood 6 No N/A
Blood vessel 4 No  (1/4) N/A
Bone 15 No  (4/15)  Wholemount images  Section images
Bone marrow 6 No N/A
Brain 22 No  (20/22)  Wholemount images  Section images
Brainstem 22 No  (14/22)  Wholemount images  Section images
Brown adipose tissue 20 No N/A
Cartilage tissue 22 No N/A
Cecum 12 No  (12/383)  (7/12)  Wholemount images
Cerebellum 22 No  (18/22)  Wholemount images  Section images
Cerebral cortex 22 No  (14/22)  Wholemount images
Chest bone 10 No  Wholemount images
Colon 10 No  (12/127)  (8/10) N/A
Cranium 6 No N/A
Diaphragm 10 No N/A
Duodenum 8 No  (2/127)  (8/8)  Wholemount images
Epididymis 12 No  (18/134)  (3/12)  Wholemount images
Esophagus 18 No  (7/415)  (5/18)  Wholemount images
Eye 22 No  (9/22)  Wholemount images  Section images
Gall bladder 18 No  Wholemount images
Gonadal fat pad 8 No N/A
Harderian gland 10 No  Wholemount images
Heart 22 No  Wholemount images
Hindlimb 10 No N/A
Hippocampus 22 No  (14/22)  Wholemount images
Hypothalamus 22 No  (14/22)  Wholemount images
Ileum 8 No  (14/127)  (7/8)  Wholemount images
Jejunum 8 No  (6/127)  (6/8)  Wholemount images
Kidney 22 No  (18/584)  (16/22)  Wholemount images
Large intestine 22 No  (10/584)  (16/22)  Wholemount images
Liver 22 No  Wholemount images
Lower urinary tract 22 No  (5/22)  Wholemount images
Lung 22 No  Wholemount images
Lymph node 22 No  Wholemount images
Main olfactory bulb 6 No  (4/6)  Wholemount images
Mammary gland 22 No  (1/22) N/A
Mesenteric adipose tissue 8 No N/A
Mesenteric lymph node 12 No  Wholemount images
Midbrain 10 No  (10/10) N/A
Esophagus 4 No N/A
Olfactory lobe 22 No  (17/22)  Wholemount images  Section images
Oral epithelium 10 No N/A
Ovary 22 No  (1/584)  (6/22)  Wholemount images  Section images
Oviduct 22 No  (7/22)  Wholemount images  Section images
Pancreas 22 No  (5/584)  (2/22)  Wholemount images
Parathyroid gland 18 No  (1/18)  Wholemount images
Parotid gland 10 No  Wholemount images
Penis 10 No  (3/10)  Wholemount images
Peripheral nervous system 22 No  (15/22)  Wholemount images
Peyer's patch 4 No N/A
Peyer's patch 18 No N/A
Pituitary gland 22 No  (15/22)  Wholemount images
Prostate gland 22 No  (12/584)  (3/22)  Wholemount images
Quadriceps 8 No  (1/8) N/A
Sciatic nerve 10 No  (3/10)  Wholemount images
Skeletal muscle 18 No N/A
Skeletal muscle tissue 4 No N/A
Skin 22 No  (3/22)  Wholemount images  Section images
Small intestine 22 No  (9/584)  (14/22)  Wholemount images
Spinal cord 22 No  (22/22)  Wholemount images  Section images
Spleen 22 No  (2/584)  Wholemount images
Stomach 22 No  (12/584)  (12/22)  Wholemount images
Stomach pyloric region 10 No N/A
Striatum 22 No  (14/22)  Wholemount images
Sublingual gland 10 No  (2/10)  Wholemount images
Submandibular gland 12 No  (2/132)  (1/12)  Wholemount images
Testis 22 No  (2/584)  (9/22)  Wholemount images
Thalamus 6 No  (6/6) N/A
Thymus 22 No  Wholemount images
Thyroid gland 22 No  (15/584)  (4/22)  Wholemount images
Tongue 10 No  (5/127)  (4/10)  Wholemount images
Trachea 22 No  Wholemount images
Trigeminal V nerve 12 No  (8/12)  Wholemount images
Urinary bladder 14 No  (4/14)  Wholemount images
Uterus 22 No  (8/22)  Wholemount images  Section images
Vagina 10 No  Wholemount images
Vas deferens 12 No  (15/388)  (2/12)  Wholemount images
Vascular system 18 No  (2/18) N/A
Vesicular gland 12 No  (1/12)  Wholemount images
White adipose tissue 22 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 7  (1/47)  (10/11) N/A
Axial skeleton 7  (1/51)  (10/11) N/A
Brain 16  (6/485)  (20/23) N/A
Central nervous system ganglion 3  (1/51)  (3/4) N/A
Cranium 2  (1/46)  (2/3) N/A
Dorsal root ganglion 3  (1/47)  (2/4) N/A
Ear 16  (1/485)  (18/23) N/A
Embryo 16  (1/485)  (21/23)  Wholemount images
Outer ear 2  (1/47)  (2/3) N/A
Eye 16  (1/485)  (21/23)  Wholemount images
Femur pre-cartilage condensation 2  (1/46)  (2/3) N/A
Foot 16  (1/485)  (10/23) N/A
Forearm 6  (1/282)  (6/7) N/A
Forebrain 16  (1/485)  (20/23)  Wholemount images
Forelimb 16  (1/485)  (21/23)  Wholemount images
Fronto-nasal process 7  (1/48)  (9/11) N/A
Gut 3  (1/50)  (3/4) N/A
Hand 16  (1/485)  (10/23) N/A
Head 16  (5/485)  (21/23)  Wholemount images
Head mesenchyme 7  (1/47)  (9/10) N/A
Heart 16  (1/485)  (13/23)  Wholemount images
Heart ventricle 7  (1/47)  (10/11) N/A
Hindbrain 16  (6/485)  (20/23)  Wholemount images
Hindlimb 16  (1/485)  (21/23)  Wholemount images
Humerus pre-cartilage condensation 2  (1/46)  (2/3) N/A
Inner ear 2  (1/46)  (2/3) N/A
Intestine 2  (1/47)  (2/3) N/A
Liver 16  (1/485)  (5/23)  Wholemount images
Lower leg 6  (1/282)  (6/7) N/A
Lung 16  (1/485)  (13/23) N/A
Mandibular process 16  (1/485)  (19/23)  Wholemount images
Maxillary process 16  (1/485)  (19/23)  Wholemount images
Meckel's cartilage 5  (8/8) N/A
Mesonephros of female 2  (1/46)  (2/3) N/A
Mesonephros of male 2  (1/46)  (2/3) N/A
Metanephros 2  (1/46)  (2/3) N/A
Midbrain 16  (1/485)  (20/23)  Wholemount images
Nasal septum 2  (1/47)  (2/3) N/A
Nose 8  (1/51)  (11/12) N/A
Notochord 7  (1/47)  (10/11) N/A
Oral cavity 16  (1/485)  (14/23) N/A
Outflow tract 7  (1/47)  (10/11) N/A
Pancreas 2  (1/46)  (2/3) N/A
Pericardium 3  (1/46)  (3/4) N/A
Pharynx 2  (1/46)  (2/3) N/A
Radius-ulna pre-cartilage condensation 2  (1/46)  (2/3) N/A
Rib pre-cartilage condensation 2  (1/46)  (2/3) N/A
Skeleton 7  (1/51)  (10/11) N/A
Skin 16  (1/485)  (15/23) N/A
Spinal cord 6  (1/50)  (8/9) N/A
Stomach 2  (1/46)  (2/3) N/A
Tail 16  (1/485)  (20/23)  Wholemount images
Tail somite 16  (1/485)  (17/23)  Wholemount images
Thoracic vertebral cartilage condensation 2  (1/46)  (2/3) N/A
Tongue 2  (1/46)  (2/3) N/A
Trachea 3  (1/50)  (3/4) N/A
Trunk mesenchyme 7  (1/47)  (9/11) N/A
Umbilical artery embryonic part 2  (1/47)  (2/3) N/A
Umbilical vein embryonic part 2  (1/47)  (2/3) N/A
Upper arm 6  (1/282)  (6/7) N/A
Upper leg 6  (1/282)  (6/7) N/A
Urinary system 3  (1/50)  (3/4) N/A
Vibrissa 7  (1/47)  (10/11) N/A

 Associated Images

Eye Morphology: Images Slit Lamp
1 Images
Eye Morphology: Images Ophthalmoscopy
8 Images
Embryo LacZ: LacZ images wholemount
79 Images
Sleep Wake: Wake state (bmp file)
3 Images
X-ray: XRay Images Dorso Ventral
230 Images
X-ray: XRay Images Lateral Orientation
191 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
95 Images
Gross Pathology and Tissue Collection
9 Images
Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
4 Images
X-ray: XRay Images Skull Lateral Orientation
70 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Dbn1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Dbn1em2(IMPC)Mbp Null reporter Mice, Tissue
Dbn1em1(IMPC)Bay Exon Deletion Mice, Tissue
Dbn1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Dbn1em1(IMPC)J Intra-exdel deletion Mice

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