Gene: Dbn1

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Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Dbn1tm1b(KOMP)Wtsi HOM   Early adult 0.00
decreased total body fat amount Dbn1tm1a(KOMP)Wtsi HOM Early adult 4.58×10-37
abnormal vertebrae morphology Dbn1tm1b(KOMP)Wtsi HET Early adult 2.01×10-05
abnormal embryo size Dbn1em2(IMPC)Mbp HOM E9.5 0.00
decreased total retina thickness Dbn1em1(IMPC)Bay HOM Early adult 2.23×10-08
abnormal retina morphology Dbn1tm1b(KOMP)Wtsi HET   Early adult 2.91×10-05
increased CD8-positive, alpha-beta T cell number Dbn1tm1b(KOMP)Wtsi HET   Early adult 0.00
abnormal embryo size Dbn1tm1b(KOMP)Wtsi HET E15.5 0.00
increased leukocyte cell number Dbn1tm1a(KOMP)Wtsi HOM Early adult 2.67×10-06
decreased circulating free fatty acid level Dbn1tm1b(KOMP)Wtsi HET Early adult 1.28×10-06
abnormal midbrain development Dbn1tm1b(KOMP)Wtsi HOM E9.5 0.00
decreased grip strength Dbn1tm1b(KOMP)Wtsi HET Early adult 4.34×10-05
increased lean body mass Dbn1tm1a(KOMP)Wtsi HOM Early adult 6.02×10-34
abnormal embryo size Dbn1tm1b(KOMP)Wtsi HOM E18.5 0.00
enlarged heart Dbn1tm1b(KOMP)Wtsi HET Early adult 0.00
decreased mean platelet volume Dbn1tm1b(KOMP)Wtsi HET Early adult 1.79×10-05
increased bone mineral content Dbn1tm1b(KOMP)Wtsi HET Early adult 1.44×10-07
decreased grip strength Dbn1em1(IMPC)J HOM Early adult 3.03×10-05
abnormal embryo turning Dbn1em2(IMPC)Mbp HOM E9.5 0.00
abnormal chorioallantoic fusion Dbn1em2(IMPC)Mbp HOM E9.5 0.00
abnormal allantois morphology Dbn1em2(IMPC)Mbp HOM E9.5 0.00
preweaning lethality, incomplete penetrance Dbn1tm1a(KOMP)Wtsi HOM   Early adult 0.00
abnormal neural tube closure Dbn1tm1b(KOMP)Wtsi HOM E9.5 0.00
increased bone mineral density Dbn1tm1a(KOMP)Wtsi HOM Early adult 1.62×10-14
decreased startle reflex Dbn1tm1b(KOMP)Wtsi HET Early adult 3.05×10-05
increased hemoglobin content Dbn1tm1b(KOMP)Wtsi HET Early adult 2.60×10-05
preweaning lethality, incomplete penetrance Dbn1tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased lean body mass Dbn1tm1b(KOMP)Wtsi HET Early adult 8.60×10-10
decreased circulating HDL cholesterol level Dbn1tm1a(KOMP)Wtsi HOM Early adult 9.06×10-12
increased bone mineral content Dbn1tm1a(KOMP)Wtsi HOM Early adult 2.65×10-07
decreased body weight Dbn1tm1a(KOMP)Wtsi HOM Early adult 5.49×10-22
increased hematocrit Dbn1tm1b(KOMP)Wtsi HET   Early adult 3.59×10-05
abnormal head shape Dbn1tm1b(KOMP)Wtsi HOM E18.5 0.00
abnormal chorioallantoic fusion Dbn1em2(IMPC)Mbp HET E9.5 0.00
decreased circulating serum albumin level Dbn1tm1a(KOMP)Wtsi HOM Early adult 2.12×10-05
increased circulating alkaline phosphatase level Dbn1tm1a(KOMP)Wtsi HET Early adult 5.12×10-05
abnormal liver morphology Dbn1tm1b(KOMP)Wtsi HET Early adult 0.00
increased circulating phosphate level Dbn1tm1b(KOMP)Wtsi HET Early adult 1.49×10-05
abnormal heart morphology Dbn1tm1b(KOMP)Wtsi HET Early adult 0.00
decreased caudal vertebrae number Dbn1tm1b(KOMP)Wtsi HET Early adult 4.51×10-05
abnormal coat appearance Dbn1em1(IMPC)Bay HOM Early adult 6.49×10-06
decreased circulating serum albumin level Dbn1tm1b(KOMP)Wtsi HET Early adult 4.61×10-05
decreased circulating glycerol level Dbn1tm1a(KOMP)Wtsi HOM Early adult 5.81×10-06
abnormal hindbrain development Dbn1tm1b(KOMP)Wtsi HOM E9.5 0.00
increased fasting circulating glucose level Dbn1tm1b(KOMP)Wtsi HET   Early adult 1.21×10-05
increased mean corpuscular hemoglobin Dbn1tm1a(KOMP)Wtsi HOM Early adult 1.49×10-06
decreased circulating iron level Dbn1tm1a(KOMP)Wtsi HOM Early adult 2.26×10-06
abnormal facial morphology Dbn1tm1b(KOMP)Wtsi HOM E18.5 0.00
increased circulating magnesium level Dbn1tm1b(KOMP)Wtsi HET Early adult 3.51×10-05
decreased total body fat amount Dbn1tm1b(KOMP)Wtsi HET   Early adult 1.05×10-11
decreased circulating fructosamine level Dbn1tm1a(KOMP)Wtsi HOM Early adult 7.98×10-05
abnormal forebrain development Dbn1tm1b(KOMP)Wtsi HOM E9.5 0.00
improved glucose tolerance Dbn1tm1b(KOMP)Wtsi HET Early adult 9.69×10-07
decreased total body fat amount Dbn1tm1a(KOMP)Wtsi HET   Early adult 8.48×10-05
decreased circulating cholesterol level Dbn1tm1a(KOMP)Wtsi HOM Early adult 3.72×10-09
decreased total retina thickness Dbn1tm1b(KOMP)Wtsi HET Early adult 9.99×10-07
increased lean body mass Dbn1tm1a(KOMP)Wtsi HET   Early adult 3.29×10-06

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 24 No  (3/590)  (12/24)  Wholemount images  Section images
Aorta 24 No  (1/590)  (6/24)  Wholemount images  Section images
Blood 8 No N/A
Blood vessel 4 No  (1/4) N/A
Bone 17 No  (5/17)  Wholemount images  Section images
Bone marrow 8 No N/A
Brain 24 No  (3/590)  (22/24)  Wholemount images  Section images
Brainstem 24 No  (2/590)  (15/24)  Wholemount images  Section images
Brown adipose tissue 22 No  Section images
Cartilage tissue 24 No  (1/24)  Section images
Cecum 14 No  (12/377)  (7/14)  Wholemount images  Section images
Cerebellum 24 No  (3/590)  (20/24)  Wholemount images  Section images
Cerebral cortex 24 No  (2/590)  (16/24)  Wholemount images  Section images
Chest bone 12 No  Wholemount images  Section images
Colon 12 No  (12/127)  (8/12)  Wholemount images  Section images
Cranium 8 No  (1/8)  Section images
Diaphragm 12 No  Section images
Duodenum 10 No  (2/127)  (8/10)  Wholemount images  Section images
Epididymis 14 No  (18/134)  (3/14)  Wholemount images  Section images
Esophagus 20 No  (7/415)  (5/20)  Wholemount images  Section images
Eye 24 No  (10/24)  Wholemount images  Section images
Gall bladder 20 No  Wholemount images  Section images
Gonadal fat pad 10 No N/A
Harderian gland 12 No  Wholemount images  Section images
Heart 24 No  (1/590)  Wholemount images  Section images
Hindlimb 12 No  Section images
Hippocampus 24 No  (3/590)  (16/24)  Wholemount images  Section images
Hypothalamus 24 No  (2/590)  (16/24)  Wholemount images  Section images
Ileum 10 No  (14/127)  (7/10)  Wholemount images  Section images
Jejunum 10 No  (6/127)  (6/10)  Wholemount images  Section images
Kidney 24 No  (20/590)  (18/24)  Wholemount images  Section images
Large intestine 24 No  (10/590)  (16/24)  Wholemount images  Section images
Liver 24 No  Wholemount images  Section images
Lower urinary tract 24 No  (1/590)  (7/24)  Wholemount images  Section images
Lung 24 No  (1/590)  Wholemount images  Section images
Lymph node 24 No  Wholemount images  Section images
Main olfactory bulb 8 No  (4/8)  Wholemount images
Mammary gland 24 No  (1/24)  Section images
Mesenteric adipose tissue 10 No N/A
Mesenteric lymph node 14 No  Wholemount images
Midbrain 12 No  (10/12)  Wholemount images  Section images
Esophagus 4 No N/A
Olfactory lobe 24 No  (2/590)  (19/24)  Wholemount images  Section images
Oral epithelium 12 No  (1/12)  Section images
Ovary 24 No  (1/590)  (7/24)  Wholemount images  Section images
Oviduct 24 No  (8/24)  Wholemount images  Section images
Pancreas 24 No  (5/590)  (3/24)  Wholemount images  Section images
Parathyroid gland 20 No  (3/20)  Wholemount images  Section images
Parotid gland 12 No  Wholemount images
Penis 12 No  (4/12)  Wholemount images  Section images
Peripheral nervous system 24 No  (1/590)  (15/24)  Wholemount images  Section images
Peyer's patch 4 No N/A
Peyer's patch 20 No  Section images
Pituitary gland 24 No  (1/590)  (17/24)  Wholemount images  Section images
Prostate gland 24 No  (12/590)  (3/24)  Wholemount images  Section images
Quadriceps 10 No  (1/10)  Section images
Sciatic nerve 12 No  (3/12)  Wholemount images  Section images
Skeletal muscle 20 No  Section images
Skeletal muscle tissue 4 No N/A
Skin 24 No  (3/24)  Wholemount images  Section images
Small intestine 24 No  (9/590)  (14/24)  Wholemount images  Section images
Spinal cord 24 No  (2/590)  (24/24)  Wholemount images  Section images
Spleen 24 No  (2/590)  Wholemount images  Section images
Stomach 24 No  (13/590)  (14/24)  Wholemount images  Section images
Stomach pyloric region 12 No N/A
Striatum 24 No  (3/590)  (16/24)  Wholemount images  Section images
Sublingual gland 12 No  (2/12)  Wholemount images  Section images
Submandibular gland 14 No  (2/132)  (1/14)  Wholemount images  Section images
Testis 24 No  (5/590)  (10/24)  Wholemount images  Section images
Thalamus 8 No  (6/8)  Section images
Thymus 24 No  (1/24)  Wholemount images  Section images
Thyroid gland 24 No  (16/590)  (6/24)  Wholemount images  Section images
Tongue 12 No  (5/127)  (5/12)  Wholemount images  Section images
Trachea 24 No  (2/590)  Wholemount images  Section images
Trigeminal V nerve 14 No  (8/14)  Wholemount images  Section images
Urinary bladder 16 No  (6/16)  Wholemount images  Section images
Uterus 24 No  (9/24)  Wholemount images  Section images
Vagina 12 No  Wholemount images
Vas deferens 14 No  (15/388)  (2/14)  Wholemount images  Section images
Vascular system 20 No  (2/20)  Section images
Vesicular gland 14 No  (1/14)  Wholemount images  Section images
White adipose tissue 24 No  Section images
LacZ Section Images

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View all 13 images

View all 7 images

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 7  (1/61)  (10/11) N/A
Axial skeleton 7  (1/65)  (10/11) N/A
Brain 18  (6/506)  (20/25) N/A
Central nervous system ganglion 5  (1/74)  (3/6) N/A
Cranium 4  (1/65)  (2/5) N/A
Dorsal root ganglion 3  (1/61)  (2/4) N/A
Ear 18  (1/506)  (18/25) N/A
Embryo 18  (1/507)  (23/25)  Wholemount images
Outer ear 4  (1/72)  (2/5) N/A
Eye 18  (1/506)  (21/25)  Wholemount images
Femur pre-cartilage condensation 2  (1/56)  (2/3) N/A
Foot 18  (1/506)  (10/25) N/A
Forearm 8  (1/303)  (6/9) N/A
Forebrain 18  (1/506)  (20/25)  Wholemount images
Forelimb 18  (1/506)  (21/25)  Wholemount images
Fronto-nasal process 7  (1/62)  (9/11) N/A
Gut 3  (1/60)  (3/4) N/A
Hand 18  (1/506)  (10/25) N/A
Head 18  (5/506)  (21/25)  Wholemount images
Head mesenchyme 7  (1/61)  (9/10) N/A
Heart 18  (1/506)  (13/25)  Wholemount images
Heart ventricle 7  (1/61)  (10/11) N/A
Hindbrain 18  (6/506)  (20/25)  Wholemount images
Hindlimb 18  (1/506)  (21/25)  Wholemount images
Humerus pre-cartilage condensation 4  (1/65)  (2/5) N/A
Inner ear 4  (1/65)  (2/5) N/A
Intestine 2  (1/59)  (2/3) N/A
Liver 18  (1/504)  (5/25)  Wholemount images
Lower leg 8  (1/303)  (6/9) N/A
Lung 18  (1/504)  (13/25) N/A
Mandibular process 18  (1/506)  (19/25)  Wholemount images
Maxillary process 18  (1/506)  (19/25)  Wholemount images
Meckel's cartilage 5  (8/8) N/A
Mesonephros of female 2  (1/56)  (2/3) N/A
Mesonephros of male 2  (1/56)  (2/3) N/A
Metanephros 2  (1/56)  (2/3) N/A
Midbrain 18  (1/506)  (20/25)  Wholemount images
Nasal septum 2  (1/61)  (2/3) N/A
Nose 10  (1/76)  (11/14) N/A
Notochord 7  (1/61)  (10/11) N/A
Oral cavity 18  (1/504)  (14/25) N/A
Outflow tract 7  (1/61)  (10/11) N/A
Pancreas 2  (1/56)  (2/3) N/A
Pericardium 3  (1/56)  (3/4) N/A
Pharynx 2  (1/57)  (2/3) N/A
Radius-ulna pre-cartilage condensation 4  (1/65)  (2/5) N/A
Rib pre-cartilage condensation 2  (1/58)  (2/3) N/A
Skeleton 9  (1/76)  (10/13) N/A
Skin 18  (1/506)  (15/25) N/A
Spinal cord 8  (1/73)  (8/11) N/A
Stomach 2  (1/56)  (2/3) N/A
Tail 18  (1/506)  (20/25)  Wholemount images
Tail somite 18  (1/506)  (17/25)  Wholemount images
Thoracic vertebral cartilage condensation 2  (1/56)  (2/3) N/A
Tongue 2  (1/56)  (2/3) N/A
Trachea 3  (1/60)  (3/4) N/A
Trunk mesenchyme 7  (1/61)  (9/11) N/A
Umbilical artery embryonic part 2  (1/61)  (2/3) N/A
Umbilical vein embryonic part 2  (1/61)  (2/3) N/A
Upper arm 8  (1/303)  (6/9) N/A
Upper leg 8  (1/303)  (6/9) N/A
Urinary system 3  (1/60)  (3/4) N/A
Vibrissa 9  (1/72)  (10/13) N/A

 Associated Images

Eye Morphology: VIP of right fundus
9 Images
X-ray: XRay Images Skull Lateral Orientation
88 Images
X-ray: XRay Images Hind Leg and Hip
31 Images
Adult LacZ: LacZ Images Section
257 Images
X-ray: XRay Images Whole Body Dorso Ventral
162 Images
Adult LacZ: LacZ Images Wholemount
246 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
113 Images
X-ray: XRay Images Forepaw
89 Images
X-ray: XRay Images Forepaw
16 Images
Ear epidermis immunophenotyping
12 Images
Legacy Phenotype Associated Images

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View all 13 images

View all 6 images

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 Disease Models

No associations by disease annotation and gene orthology found.
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MGI Allele Allele Type Produced
Dbn1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Dbn1em1(IMPC)J Intra-exon deletion Mice
Dbn1em1(IMPC)Bay Exon Deletion Mice, Tissue
Dbn1em2(IMPC)Mbp Null reporter Mice, Tissue
Dbn1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells