Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

ras homolog family member J
1110005O19Rik,  TC10L,  Arhj,  TCL

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rhoj mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rhoj by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Retinal Dysplasia, Primary
Retinal dysplasia, Falciform retinal fold OMIM:312550
Stargardt Disease 1
Retinitis pigmentosa inversa, Macular degeneration, Bull's eye maculopathy OMIM:248200
Macular Degeneration, Age-Related, 4
Macular degeneration OMIM:610698
Macular Degeneration, Age-Related, 15
Macular degeneration OMIM:615591
Macular Degeneration, Age-Related, 2
Macular degeneration OMIM:153800
Macular Degeneration, Age-Related, 11
Macular degeneration OMIM:611953
Macular Degeneration, Age-Related, 6
Macular degeneration OMIM:613757
Central Retinal Vein Occlusion
Macular edema, Retinal vascular tortuosity, Macular degeneration, Epiretinal membrane, Retinal ne... ORPHA:411527
Vitreoretinopathy, Neovascular Inflammatory
Large hyperpigmented retinal spots, Posterior retinal neovascularization, Vitreous hemorrhage, Pe... OMIM:193235
Exudative Vitreoretinopathy 2, X-Linked
Exudative vitreoretinopathy, Intraretinal exudate, Retinal fold, Retinal hole, Falciform retinal ... OMIM:305390
Exudative Vitreoretinopathy 1
Exudative vitreoretinopathy, Vitreous hemorrhage, Falciform retinal fold, Posterior vitreous deta... OMIM:133780
Familial Exudative Vitreoretinopathy
Macular exudate, Vitreous hemorrhage, Tractional retinal detachment, Macular edema, Falciform ret... ORPHA:891
Reese Retinal Dysplasia
Retinal dysplasia, Remnants of the hyaloid vascular system OMIM:266400
Eales Disease
Vitreous hemorrhage, Tractional retinal detachment, Macular edema, Vitreous haze, Vitritis, Retin... ORPHA:40923
Congenital Factor X Deficiency
Subarachnoid hemorrhage, Hemoperitoneum, Post-partum hemorrhage, Antepartum hemorrhage, Abnormal ... ORPHA:328
Acquired Purpura Fulminans
Macular purpura, Intracranial hemorrhage, Internal hemorrhage, Shock, Neoplasm, Prolonged prothro... ORPHA:49566
Coloboma Of Optic Nerve
Retinal detachment, Optic disc coloboma OMIM:120430
Retinal arteriolar constriction, Vitreous hemorrhage, Retinal arteriolar occlusion, Abnormality o... OMIM:193220
Rhabdoid Tumor
Neoplasm of the central nervous system, Sarcoma, Neoplasm of the liver, Hypertension, Internal he... ORPHA:69077
Klippel-Trénaunay Syndrome
Patent ductus arteriosus, Pulmonary embolism, Congestive heart failure, Internal hemorrhage, Hema... ORPHA:90308
Congenital Fibrinogen Deficiency
Subcutaneous hemorrhage, Abnormal umbilical stump bleeding, Abnormal bleeding, Internal hemorrhag... ORPHA:335
Wiskott-Aldrich Syndrome
Lymphoma, Sudden cardiac death, Petechiae, Vasculitis, Purpura, Intracranial hemorrhage, Bruising... ORPHA:906
Cleft Palate, Proliferative Retinopathy, And Developmental Delay
Retinal neovascularization OMIM:619074
Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations
Retinal neovascularization, Retinal cotton wool spot, Macular edema, Abnormal retinal vascular mo... ORPHA:247691
Crimean-Congo Hemorrhagic Fever
Hypotension, Hemoperitoneum, Tachycardia, Abnormal left ventricular function, Subdural hemorrhage... ORPHA:99827
Tuberous Sclerosis Complex
Parathyroid adenoma, Renal angiomyolipoma, Cardiac rhabdomyoma, Pancreatic endocrine tumor, Retin... ORPHA:805
Inhalational Anthrax
Hypotension, Internal hemorrhage ORPHA:247257
Hemorrhagic Fever-Renal Syndrome
Hypotension, Petechiae, Intracranial hemorrhage, Internal hemorrhage, Ecchymosis, Shock, Epistaxi... ORPHA:340
Superficial Siderosis
Neoplasm of the central nervous system, Abnormal bleeding, Internal hemorrhage, Subarachnoid hemo... ORPHA:247245
Hepatocellular Carcinoma
Hypotension, Internal hemorrhage, Neoplasm, Portal hypertension, Budd-Chiari syndrome ORPHA:88673
Marburg Hemorrhagic Fever
Hypotension, Hypovolemia, Petechiae, Abnormal bleeding, Bruising susceptibility, Internal hemorrh... ORPHA:99826
Hellp Syndrome
Hypotension, Cerebral hemorrhage, Prolonged prothrombin time, Internal hemorrhage ORPHA:244242
Yellow Fever
Reduced left ventricular ejection fraction, Supraventricular arrhythmia, Abnormal bleeding, Inter... ORPHA:99829
Vascular Ehlers-Danlos Syndrome
Transient ischemic attack, Abnormal bleeding, Hypertension, Internal hemorrhage, Bruising suscept... ORPHA:286


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rhoj

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rhoj.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The RhoJ-BAD signaling network: An Achilles' heel for BRAF mutant melanomas. PLoS genetics (July 2017) Rhojtm1a(KOMP)Wtsi PMC5549996
RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly. Journal of cell science (June 2014) Rhojtm1a(KOMP)Wtsi PMC4106786
Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Blood (April 2012) Rhojtm1a(KOMP)Wtsi 22535667

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MGI Allele Allele Type Produced
Rhojtm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Rhojtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Rhojtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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