Gene Summary

Name:
tyrosine kinase, non-receptor, 1
Synonyms:
Tnk1a,  Tnk1b,  Kos1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased total body fat amount Tnk1tm1b(EUCOMM)Hmgu HOM Early adult 1.78×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Esophagus  Section images heterozygote 100% (2 of 2)
Kidney  Section images heterozygote 100% (2 of 2)
Large intestine  Section images heterozygote 100% (2 of 2)
Lung  Section images heterozygote 100% (2 of 2)
Ovary  Section images heterozygote 50% (1 of 2)
Oviduct  Section images heterozygote 50% (1 of 2)
Pancreas  Section images heterozygote 100% (2 of 2)
Pituitary gland  Section images heterozygote 50% (1 of 2)
Skin  Section images heterozygote 100% (2 of 2)
Small intestine  Section images heterozygote 100% (2 of 2)
Stomach  Section images heterozygote 100% (2 of 2)
Submandibular gland  Section images heterozygote 50% (1 of 2)
Testis  Section images heterozygote 50% (1 of 2)
Thymus  Section images heterozygote 100% (2 of 2)
Thyroid gland  Section images heterozygote 100% (2 of 2)
Trachea  Section images heterozygote 100% (2 of 2)
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 0.0% (0 of 2)
Brainstem N/A heterozygote 0.0% (0 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote 0.0% (0 of 2)
Epididymis N/A heterozygote 0.0% (0 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 0.0% (0 of 2)
Hippocampus N/A heterozygote 0.0% (0 of 2)
Hypothalamus N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Midbrain N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote Not available
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote 0.0% (0 of 2)
Thalamus N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote 0.0% (0 of 2)
Vesicular gland N/A heterozygote Not available
White adipose tissue N/A heterozygote 0.0% (0 of 2)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Brain N/A heterozygote 0.0% (0 of 2)
Dorsal root ganglion N/A heterozygote 0.0% (0 of 2)
Ear N/A heterozygote 0.0% (0 of 2)
Embryo N/A heterozygote 0.0% (0 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Footplate N/A heterozygote 0.0% (0 of 2)
Forebrain N/A heterozygote 0.0% (0 of 2)
Forelimb N/A heterozygote 0.0% (0 of 2)
Fronto-nasal process N/A heterozygote 0.0% (0 of 2)
Handplate N/A heterozygote 0.0% (0 of 2)
Head N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 0.0% (0 of 2)
Hindbrain N/A heterozygote 0.0% (0 of 2)
Hindlimb N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lung N/A heterozygote 0.0% (0 of 2)
Mandibular process N/A heterozygote 0.0% (0 of 2)
Maxillary process N/A heterozygote 0.0% (0 of 2)
Midbrain N/A heterozygote 0.0% (0 of 2)
Nose N/A heterozygote 0.0% (0 of 2)
Oral cavity N/A heterozygote 0.0% (0 of 2)
Skin N/A heterozygote 0.0% (0 of 2)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Tail somite N/A heterozygote 0.0% (0 of 2)
Tail N/A heterozygote 0.0% (0 of 2)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.7% (4 of 573)
aorta 0.18% (1 of 571)
brain 0.53% (3 of 570)
brainstem 0.35% (2 of 564)
brown adipose tissue 0.0%
cartilage tissue 0.18% (1 of 569)
cerebellum 0.53% (3 of 565)
cerebral cortex 0.35% (2 of 565)
epididymis 13.08% (17 of 130)
esophagus 1.8% (7 of 389)
eye 0.0%
heart 0.35% (2 of 566)
hippocampus 0.53% (3 of 571)
hypothalamus 0.36% (2 of 560)
kidney 3.72% (21 of 565)
large intestine 1.78% (10 of 561)
liver 0.0%
lower urinary tract 0.0%
lung 0.35% (2 of 577)
lymph node 0.18% (1 of 566)
mammary gland 0.0%
midbrain 0.0%
olfactory lobe 0.18% (1 of 553)
ovary 0.18% (1 of 566)
oviduct 0.0%
pancreas 0.89% (5 of 559)
peripheral nervous system 0.35% (2 of 574)
peyers patch 0.0%
pituitary gland 0.18% (1 of 570)
prostate gland 1.77% (10 of 564)
skeletal muscle 0.0%
skin 0.18% (1 of 563)
small intestine 1.59% (9 of 565)
spinal cord 0.53% (3 of 566)
spleen 0.53% (3 of 566)
stomach 2.12% (12 of 565)
striatum 0.53% (3 of 567)
submandibular gland 1.56% (2 of 128)
testis 1.05% (6 of 572)
thalamus 0.0%
thymus 0.18% (1 of 567)
thyroid gland 2.84% (16 of 563)
trachea 0.53% (3 of 562)
urinary bladder 0.0%
uterus 0.0%
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 1.18% (6 of 508)
dorsal root ganglion 1.67% (1 of 60)
ear 0.2% (1 of 508)
embryo 0.2% (1 of 509)
eye 0.2% (1 of 508)
footplate 0.2% (1 of 508)
forebrain 0.2% (1 of 508)
forelimb 0.2% (1 of 508)
fronto-nasal process 1.64% (1 of 61)
handplate 0.2% (1 of 508)
head 0.98% (5 of 508)
heart 0.2% (1 of 508)
hindbrain 1.18% (6 of 508)
hindlimb 0.2% (1 of 508)
liver 0.2% (1 of 503)
lung 0.2% (1 of 503)
mandibular process 0.2% (1 of 508)
maxillary process 0.2% (1 of 508)
midbrain 0.2% (1 of 508)
nose 1.28% (1 of 78)
oral cavity 0.2% (1 of 503)
skin 0.2% (1 of 508)
spinal cord 1.39% (1 of 72)
tail 0.2% (1 of 508)
tail somite group 0.2% (1 of 508)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Forepaw

10 Images

Adult LacZ

LacZ Images Section

16 Images

Sleep Wake

Wake state (bmp file)

7 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Eye Morphology

Images Ophthalmoscopy

2 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Electroretinography 2

Rod and cone PDF

4 Images

Human diseases caused by Tnk1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tnk1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Lipomatosis, Multiple Symmetric
Lipoma OMIM:151800
Lipomatosis, Multiple
Multiple lipomas OMIM:151900
Myofibromatosis, Infantile, 1
Fibroma, Myofibromatosis OMIM:228550
Melanoma-Pancreatic Cancer Syndrome
Pancreatic squamous cell carcinoma, Pancreatic adenocarcinoma, Oropharyngeal squamous cell carcin... OMIM:606719
Cerebral Sarcoma
Fibrosarcoma, Neoplasm OMIM:117600
Tumor Predisposition Syndrome
Cutaneous melanoma, Meningioma, Lung adenocarcinoma, Renal cell carcinoma, Uveal melanoma OMIM:614327
Pancreatic Cancer, Susceptibility To, 5
Pancreatic adenocarcinoma, Melanoma OMIM:618680
Reticulum Cell Sarcoma
Sarcoma, Neoplasm OMIM:267730
Multiple Fibroadenomas Of The Breast
Fibroadenoma of the breast OMIM:615554
Li-Fraumeni Syndrome 2
Meningioma, Stomach cancer, Breast carcinoma, Sarcoma, Glioma OMIM:609265
Rhabdoid Tumor Predisposition Syndrome 2
Neoplasm of the central nervous system, Carcinoma OMIM:613325
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Serrated Polyposis Syndrome
Colorectal polyposis, Ovarian neoplasm, Bladder carcinoma, Hodgkin lymphoma, Adenomatous colonic ... ORPHA:157798
Lung Cancer
Non-small cell lung carcinoma, Alveolar cell carcinoma, Lung adenocarcinoma OMIM:211980
Hereditary Breast And Ovarian Cancer Syndrome
Ovarian neoplasm, Neoplasm of the pancreas, Breast carcinoma, Primary peritoneal carcinoma, Prost... ORPHA:145
Li-Fraumeni Syndrome
Adrenocortical carcinoma, Prostate neoplasm, Choriocarcinoma, Acute leukemia, Lung adenocarcinoma... OMIM:151623
Desmoid Disease, Hereditary
Desmoid tumors, Colon cancer OMIM:135290
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Fibromatosis, Gingival, 1
Gingival fibromatosis OMIM:135300
Nut Midline Carcinoma
Neuroblastoma, Pancreatic squamous cell carcinoma, Leukemia, Oropharyngeal squamous cell carcinom... ORPHA:443167
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Pancreatic Cancer
Neoplasm of the pancreas OMIM:260350
Muir-Torre Syndrome
Sebaceous gland carcinoma, Malignant genitourinary tract tumor, Benign gastrointestinal tract tum... OMIM:158320
Familial Melanoma
Neoplasm of the pancreas, Neoplasm of the breast, Neoplasm of the stomach, Melanoma ORPHA:618
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Neoplasm of the skin, Neoplasm of the rectum, Meningioma, Adenomatous colonic polyposis, Endometr... ORPHA:454840
Li-Fraumeni Syndrome
Ovarian neoplasm, Acute lymphoblastic leukemia, Astrocytoma, Thyroid carcinoma, Choriocarcinoma, ... ORPHA:524
Undifferentiated Pleomorphic Sarcoma
Soft tissue sarcoma ORPHA:2023
Pancreatic Cancer, Susceptibility To, 1
Pancreatic adenocarcinoma OMIM:606856
Pancreatic Cancer, Susceptibility To, 2
Neoplasm of the pancreas OMIM:613347
Gcgr-Related Hyperglucagonemia
Glucagonoma, Neoplasm of the pancreas, Cholelithiasis, Abnormal biliary tract morphology ORPHA:438274
Apc-Related Attenuated Familial Adenomatous Polyposis
Astrocytoma, Adenomatous colonic polyposis, Multiple gastric polyps, Papillary thyroid carcinoma,... ORPHA:247806
Enchondromatosis, Multiple, Ollier Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:166000
Lichen Sclerosus Et Atrophicus
Squamous cell carcinoma, Carcinoma OMIM:151590
Chondrosarcoma, Extraskeletal Myxoid
Chondrosarcoma OMIM:612237
Chondrosarcoma
Chondrosarcoma OMIM:215300
Hyperparathyroidism 2 With Jaw Tumors
Parathyroid carcinoma, Hurthle cell thyroid adenoma, Pancreatic adenocarcinoma, Renal cortical ad... OMIM:145001
Dermatofibrosarcoma Protuberans
Fibrosarcoma, Neoplasm of the skin ORPHA:31112
Gardner Syndrome
Astrocytoma, Adenomatous colonic polyposis, Small intestine carcinoid, Brain neoplasm, Papillary ... ORPHA:79665
Infantile Myofibromatosis
Neoplasm of the skin, Abnormal intestine morphology, Neoplasm of the lung, Neoplasm of the pancre... ORPHA:2591
Neuroendocrine Carcinoma Of Salivary Glands, Sensorineural Hearing Loss, And Enamel Hypoplasia
Unilateral vestibular Schwannoma, Carcinoma OMIM:603641
Punctate Palmoplantar Keratoderma Type 1
Neoplasm of the lung, Esophageal neoplasm, Stomach cancer, Adenocarcinoma of the small intestine,... ORPHA:79501
Desmoplastic Small Round Cell Tumor
Ovarian neoplasm, Hepatomegaly, Neoplasm of the lung, Neoplasm of the central nervous system, Neo... ORPHA:83469
Insulinoma Tumor Suppressor Gene Locus
Insulinoma OMIM:606960
Multiple Enchondromatosis, Maffucci Type
Hemangioma, Chondrosarcoma, Multiple enchondromatosis OMIM:614569
Mismatch Repair Cancer Syndrome 1
Neuroblastoma, Astrocytoma, Plexiform neurofibroma, Adenocarcinoma of the small intestine, Adenom... OMIM:276300
Familial Adenomatous Polyposis 1
Adrenocortical carcinoma, Osteoma, Astrocytoma, Adrenocortical adenoma, Adenomatous colonic polyp... OMIM:175100
Peutz-Jeghers Syndrome
Rectal prolapse, Neoplasm of the small intestine, Gastrointestinal hemorrhage, Enlarged polycysti... ORPHA:2869
Familial Adenomatous Polyposis
Neoplasm of the gallbladder, Astrocytoma, Neoplasm of the adrenal gland, Cholangiocarcinoma, Aden... ORPHA:733
Hereditary Mixed Polyposis Syndrome
Colorectal polyposis, Rectal polyposis, Thyroid carcinoma, Neoplasm of the rectum, Adenomatous co... ORPHA:157794
Tropical Calcific Pancreatitis
Pancreatic calcification, Chronic pancreatitis, Neoplasm of the pancreas OMIM:608189
Epidermodysplasia Verruciformis, Susceptibility To, 2
Verruca plana, Squamous cell carcinoma of the skin OMIM:618231
Polymerase Proofreading-Related Adenomatous Polyposis
Colorectal polyposis, Neoplasm of the rectum, Adenomatous colonic polyposis, Endometrial carcinom... ORPHA:447877
Attenuated Familial Adenomatous Polyposis
Colorectal polyposis, Rectal polyposis, Astrocytoma, Neoplasm of the stomach, Adenomatous colonic... ORPHA:220460
Milroy Disease
Neoplasm of the skin, Angiosarcoma ORPHA:79452
Bazex Syndrome
Liposarcoma, Neoplasm, Lung adenocarcinoma ORPHA:166113
Colorectal Cancer, Susceptibility To, 10
Endometrial carcinoma, Colorectal polyposis, Carcinoma OMIM:612591
Mutyh-Related Attenuated Familial Adenomatous Polyposis
Colorectal polyposis, Rectal polyposis, Adenomatous colonic polyposis, Adenocarcinoma of the colo... ORPHA:247798
Epidermodysplasia Verruciformis, X-Linked
Verrucae, Squamous cell carcinoma of the skin OMIM:305350
Familial Colorectal Cancer Type X
Neuroblastoma, Neoplasm of the rectum, Stomach cancer, Hepatocellular carcinoma, Glioblastoma mul... ORPHA:440437
Familial Multinodular Goiter
Colorectal polyposis, Ovarian neoplasm, Testicular seminoma, Thyroid carcinoma, Sertoli cell neop... ORPHA:276399
Epidermodysplasia Verruciformis, Susceptibility To, 3
Basal cell carcinoma, Squamous cell carcinoma OMIM:618267
Lynch Syndrome
Ovarian neoplasm, Neuroblastoma, Neoplasm of the rectum, Hepatocellular carcinoma, Glioblastoma m... ORPHA:144
Paraneoplastic Pemphigus
Sarcoma, B-cell lymphoma, Thymoma ORPHA:63455
Disseminated Superficial Actinic Porokeratosis
Squamous cell carcinoma ORPHA:79152
Acquired Ichthyosis
Sarcoma, Multiple myeloma, Lymphoma, Neoplasm ORPHA:454
Familial Pancreatic Carcinoma
Intestinal pseudo-obstruction, Peritoneal abscess, Functional intestinal obstruction, Pancreatic ... ORPHA:1333
Peutz-Jeghers Syndrome
Rectal prolapse, Biliary tract abnormality, Gastrointestinal carcinoma, Neoplasm of the pancreas,... OMIM:175200
Fanconi Renotubular Syndrome 5
Emphysema, Pulmonary fibrosis, Lung adenocarcinoma OMIM:618913
Cheilitis Glandularis
Abnormal salivary gland morphology, Squamous cell carcinoma, Neoplasm ORPHA:1221
Von Hippel-Lindau Syndrome
Retinal capillary hemangioma, Pancreatic cysts, Pulmonary capillary hemangiomatosis, Renal cell c... OMIM:193300
Tropical Pancreatitis
Abnormal pancreatic duct morphology, Pancreatic calcification, Pancreatic adenocarcinoma, Chronic... ORPHA:103918
Cheilitis Glandularis
Squamous cell carcinoma, Carcinoma OMIM:118330
Cutaneous Neuroendocrine Carcinoma
Multiple myeloma, Lymphoid leukemia, Brain neoplasm, Basal cell carcinoma, Squamous cell carcinom... ORPHA:79140
Ollier Disease
Hemangioma, Visceral angiomatosis, Lymphangioma, Chondrosarcoma, Neoplasm, Sarcoma, Multiple ench... ORPHA:296
Maffucci Syndrome
Neoplasm of the parathyroid gland, Ovarian neoplasm, Astrocytoma, Neoplasm of the adrenal cortex,... ORPHA:163634
Multiple Endocrine Neoplasia, Type Iv
Pancreatic endocrine tumor, Carcinoma, Pituitary adenoma, Carcinoid tumor, Primary hyperparathyro... OMIM:610755
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Multinodular goiter, Squamous cell carcinoma OMIM:618373
Juvenile Polyposis Syndrome
Rectal prolapse, Neoplasm of the stomach, Multiple gastric polyps, Intussusception, Duodenal aden... OMIM:174900
Progressive Osseous Heteroplasia
Sarcoma ORPHA:2762
Mast Cell Sarcoma
Hepatomegaly, Sarcoma ORPHA:66661
Meige Disease
Pleural effusion, Angiosarcoma ORPHA:90186
Grfoma
Neoplasm of the thymus, Neoplasm of the small intestine, Intestinal carcinoid, Primary hyperparat... ORPHA:97261
Ppoma
Adrenocortical adenoma, Hepatomegaly, Neoplasm of the pancreas, Neoplasm of the small intestine, ... ORPHA:97278
Asbestos Intoxication
Lung adenocarcinoma, Interlobular septal thickening, Pleural thickening, Abnormal pulmonary inter... ORPHA:2302
Peripheral Primitive Neuroectodermal Tumor
Ovarian neoplasm, Brain neoplasm, Neoplasm of the pancreas, Pancreatitis, Peripheral primitive ne... ORPHA:370348
Epidermodysplasia Verruciformis, Susceptibility To, 5
Verrucae, Squamous cell carcinoma of the skin OMIM:618309
Glioma Susceptibility 9
Leukemia, Glioma, Astrocytoma OMIM:616568
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Squamous cell carcinoma of the skin ORPHA:85112
Liposarcoma
Sarcoma ORPHA:69078
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Squamous cell carcinoma OMIM:613736
Pilomatrixoma
Pilomatrixoma OMIM:132600
Cancer-Associated Retinopathy
Cutaneous melanoma, Malignant genitourinary tract tumor, Neoplasm of the breast, Hodgkin lymphoma... ORPHA:71505
Desmoid Tumor
Neoplasm of the skin, Desmoid tumors, Malabsorption, Fibroma, Intestinal obstruction, Intestinal ... ORPHA:873
Somatostatinoma
Adrenocortical adenoma, Hepatomegaly, Gallbladder dysfunction, Neoplasm of the pancreas, Neoplasm... ORPHA:97283
Vipoma
Adrenocortical adenoma, Hepatomegaly, Abnormal gastrointestinal motility, Benign gastrointestinal... ORPHA:97282
Hyperkeratosis Lenticularis Perstans
Basal cell carcinoma, Squamous cell carcinoma ORPHA:409
Large Congenital Melanocytic Nevus
Cutaneous melanoma, Neoplasm of the skin, Rhabdomyosarcoma, Neoplasm, Sarcoma ORPHA:626
Schopf-Schulz-Passarge Syndrome
Squamous cell carcinoma, Apocrine hidrocystoma, Basal cell carcinoma, Poroma OMIM:224750
Congenital Macroglossia
Abnormal hepatic glycogen storage, Macroglossia, Neurofibromas ORPHA:2430
Gastrointestinal Stromal Tumor
Intestinal obstruction, Gastrointestinal stroma tumor, Neurofibromas OMIM:606764
Schöpf-Schulz-Passarge Syndrome
Ovarian neoplasm, Basal cell carcinoma, Squamous cell carcinoma ORPHA:50944
Neuroendocrine Neoplasm Of Appendix
Appendiceal mucinous neoplasm, Ovarian neoplasm, Hepatomegaly, Midgut malrotation, Functional int... ORPHA:100079
Porokeratosis
Squamous cell carcinoma of the skin ORPHA:79358
Palmoplantar Carcinoma, Multiple Self-Healing
Squamous cell carcinoma, Carcinoma OMIM:615225
Gastrointestinal Stromal Tumor
Dysphagia, Neoplasm of the rectum, Esophageal neoplasm, Gastrointestinal stroma tumor, Neoplasm o... ORPHA:44890
Pleuropulmonary Blastoma
Medulloblastoma, Rhabdomyosarcoma, Pleuropulmonary blastoma OMIM:601200
Huriez Syndrome
Squamous cell carcinoma of the skin OMIM:181600
Progeria-Short Stature-Pigmented Nevi Syndrome
Neoplasm of the pancreas, Neoplasm, Bifid uvula, Hepatic steatosis, Premature ovarian insufficien... ORPHA:2959
Gist-Plus Syndrome
Intussusception, Gastrointestinal stroma tumor, Intestinal polyposis OMIM:175510
Ovarian Fibrothecoma
Fibrosarcoma, Diffuse leiomyomatosis, Pleural effusion, Ovarian fibroma ORPHA:314478
Hyperparathyroidism-Jaw Tumor Syndrome
Dysphagia, Thyroid carcinoma, Uterine leiomyoma, Pancreatic adenocarcinoma, Pancreatitis, Renal h... ORPHA:99880
Parathyroid Carcinoma
Dysphagia, Thyroid carcinoma, Parathyroid carcinoma, Uterine leiomyoma, Pancreatic adenocarcinoma... ORPHA:143
Turcot Syndrome With Polyposis
Astrocytoma, Thyroid carcinoma, Adenomatous colonic polyposis, Leukemia, Brain neoplasm, Basal ce... ORPHA:99818
Glucagonoma
Adrenocortical adenoma, Hepatomegaly, Abnormal gastrointestinal motility, Neoplasm of the pancrea... ORPHA:97280
Multiple Endocrine Neoplasia Type 1
Duodenal ulcer, Thyroid carcinoma, Meningioma, Goiter, Gingival fibromatosis, Insulinoma, Melena,... ORPHA:652
Von Hippel-Lindau Disease
Adrenal pheochromocytoma, Pancreatic endocrine tumor, Retinal capillary hemangioma, Pancreatic cy... ORPHA:892
Birt-Hogg-Dube Syndrome
Fibrofolliculoma, Renal cell carcinoma, Large intestinal polyposis, Cutaneous leiomyosarcoma, Mul... OMIM:135150
Insulinomatosis And Diabetes Mellitus
Multiple pancreatic beta-cell adenomas OMIM:147630
Xeroderma Pigmentosum Variant
Basal cell carcinoma, Squamous cell carcinoma, Melanoma ORPHA:90342
Legius Syndrome
Non-small cell lung carcinoma, Ovarian neoplasm, Vestibular Schwannoma, Desmoid tumors, Acute mon... ORPHA:137605
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease
Acute lymphoblastic leukemia, Neoplasm of the lung, Myelodysplasia, Multiple myeloma, Hepatocellu... ORPHA:158057
Dyskeratosis Congenita, Autosomal Recessive 3
Squamous cell carcinoma OMIM:613988
Rhabdoid Tumor
Renal neoplasm, Sarcoma, Neoplasm of the central nervous system, Neoplasm of the liver ORPHA:69077
Carney Complex
Thyroid carcinoma, Gonadal neoplasm, Sertoli cell neoplasm, Neoplasm of the pharynx, Papillary th... ORPHA:1359
Terminal Osseous Dysplasia
Fibroma, Cleft palate OMIM:300244
Yellow Nail Syndrome
Neoplasm of the lung, Bronchiectasis, Biliary tract neoplasm, Pleuritis, Neoplasm, Sarcoma, Renal... ORPHA:662
Cowden Syndrome 1
High palate, Meningioma, Transitional cell carcinoma of the bladder, Goiter, Carcinoma, Ovarian c... OMIM:158350
Aicardi Syndrome
Cleft palate, Carcinoma, Hemangioma, Hepatoblastoma, Lipoma, Metastatic angiosarcoma, Recurrent p... OMIM:304050
Opsoclonus-Myoclonus Syndrome
Neuroblastoma, Neoplasm of the lung, Neoplasm, Breast carcinoma, Ovarian teratoma, Small cell lun... ORPHA:1183
Adenocarcinoma Of The Anal Canal
Neoplasm of the lung, Neoplasm of the rectum, Rectal prolapse, Neoplasm of the liver, Intestinal ... ORPHA:424016
Neurofibromatosis-Pheochromocytoma-Duodenal Carcinoid Syndrome
Carcinoid tumor, Pheochromocytoma, Neurofibromas, Jaundice OMIM:162240
Paragangliomas 4
Adrenal pheochromocytoma, Neuroblastoma, Extraadrenal pheochromocytoma, Gastrointestinal stroma t... OMIM:115310
Adrenocortical Carcinoma
Adrenocortical carcinoma, Lung adenocarcinoma ORPHA:1501
Oncogenic Osteomalacia
Carcinoma, Giant cell tumor of bone, Osteosarcoma, Neoplasm of head and neck, Neoplasm of the ske... ORPHA:352540
Juvenile Polyposis Syndrome
Visceral angiomatosis, Hemangioblastoma, Neoplasm of the small intestine, Intussusception, Gastro... ORPHA:2929
Hereditary Leiomyomatosis And Renal Cell Cancer
Uterine leiomyoma, Renal cell carcinoma, Uterine leiomyosarcoma, Cutaneous leiomyosarcoma, Cutane... OMIM:150800
Tuberous Sclerosis 2
Subungual fibromas, Cardiac rhabdomyoma, Astrocytoma, Ependymoma, Optic nerve glioma, Renal cell ... OMIM:613254
Carney-Stratakis Syndrome
Intestinal obstruction, Gastrointestinal stroma tumor, Paraganglioma ORPHA:97286
Rhabdomyosarcoma, Embryonal, 1
Embryonal rhabdomyosarcoma OMIM:268210
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Laryngeal carcinoma, Decreased testicular size, Carcinoma OMIM:610644
Rhabdomyosarcoma 2
Alveolar rhabdomyosarcoma OMIM:268220
Rhabdomyosarcoma, Embryonal, 2
Ovarian thecoma, Embryonal rhabdomyosarcoma, Nephroblastoma, Pleuropulmonary blastoma OMIM:180295
Dyskeratosis Congenita
Hepatomegaly, Neoplasm of the pancreas, Neoplasm, Lymphoma, Splenomegaly, Cirrhosis, Abnormal tes... ORPHA:1775
Combined Immunodeficiency Due To Dock8 Deficiency
Anal canal squamous carcinoma, Verrucae, Squamous cell carcinoma of the vulva, Squamous cell carc... ORPHA:217390
Neurofibromatosis, Type Iii, Mixed Central And Peripheral
Meningioma, Lisch nodules, Palmar neurofibromas, Bilateral vestibular Schwannoma, Paraspinal neur... OMIM:162260
Neurofibroma
Spinal meningioma, Plexiform neurofibroma, Neoplasm of the breast, Neoplasia of the pleura, Spina... ORPHA:252183
Primary Sclerosing Cholangitis
Neoplasm of the gallbladder, Cholangiocarcinoma, Hepatitis, Splenomegaly, Hepatosplenomegaly, Ade... ORPHA:171
Dermatomyositis
Gastrointestinal stroma tumor, Lung adenocarcinoma, Neoplasm, Lymphoma, Breast carcinoma, Abnorma... ORPHA:221
Oral Submucous Fibrosis
Oropharyngeal squamous cell carcinoma ORPHA:357154
Xeroderma Pigmentosum, Complementation Group E
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma OMIM:278740
Ichthyosis, Hystrix-Like, With Deafness
Squamous cell carcinoma OMIM:602540
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma
Fibrosarcoma, Osteosarcoma, Histiocytoma OMIM:112250
Acromesomelic Dysplasia, Grebe Type
Sarcoma ORPHA:2098
Multiple Endocrine Neoplasia, Type I
Adrenocortical adenoma, Zollinger-Ellison syndrome, Adenoma sebaceum, Insulinoma, Esophagitis, Th... OMIM:131100
Retinoblastoma
Cleft palate, Leukemia, Lymphoma, Osteosarcoma, Pinealoma, Retinoblastoma, Ewing sarcoma OMIM:180200
Epidermodysplasia Verruciformis
Verrucae, Squamous cell carcinoma ORPHA:302
Lambert-Eaton Myasthenic Syndrome
Xerostomia, Small cell lung carcinoma ORPHA:43393
Leukemia, Acute, X-Linked
Acute leukemia OMIM:308960
Necrobiosis Lipoidica
Squamous cell carcinoma ORPHA:542592
Oculocutaneous Albinism Type 1B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:79434
Xeroderma Pigmentosum, Complementation Group C
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin OMIM:278720
Carney Triad
Adrenocortical adenoma, Gastrointestinal stroma tumor, Leiomyosarcoma, Paraganglioma, Pheochromoc... ORPHA:139411
Xeroderma Pigmentosum, Variant Type
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma OMIM:278750
Neurofibromatosis, Type Iv, Of Riccardi
Lisch nodules, Atypical neurofibromatosis OMIM:162270
Colorectal Cancer, Hereditary Nonpolyposis, Type 4
Hereditary nonpolyposis colorectal carcinoma, Ovarian neoplasm, Endometrial carcinoma OMIM:614337
Common Variable Immunodeficiency
Gastrointestinal stroma tumor, Pneumonia, Bronchiectasis, Recurrent bronchitis, Lymphoma, Anal at... ORPHA:1572
Lymphedema-Distichiasis Syndrome
Fibrosarcoma, Cleft palate, Abnormality of the pulmonary vasculature ORPHA:33001
Multiple Endocrine Neoplasia Type 4
Insulinoma, Renal angiomyolipoma, Pituitary corticotropic cell adenoma, Parathyroid adenoma, Neur... ORPHA:276152
Xeroderma Pigmentosum, Complementation Group B
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin, Neoplasm OMIM:610651
X-Linked Alport Syndrome-Diffuse Leiomyomatosis
Esophageal neoplasm, Diffuse leiomyomatosis, Abnormal esophagus morphology, Fibroma, Vaginal neop... ORPHA:1018
Oculocutaneous Albinism Type 1A
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79431
Cowden Syndrome
Neoplasm of the skin, Meningioma, Endometrial carcinoma, Papilloma, Conjunctival hamartoma, High ... ORPHA:201
Werner Syndrome
Cutaneous melanoma, Ovarian neoplasm, Thyroid carcinoma, Meningioma, Neoplasm of the lung, Acral ... ORPHA:902
Cushing Syndrome Due To Ectopic Acth Secretion
Pancreatic endocrine tumor, Neuroendocrine neoplasm, Adrenal hyperplasia, Neoplasm of the stomach... ORPHA:99889
Mastocytosis
Sarcoma, Chronic leukemia, Hepatomegaly, Acute leukemia ORPHA:98292
Colorectal Cancer, Hereditary Nonpolyposis, Type 5
Endometrial carcinoma, Hereditary nonpolyposis colorectal carcinoma OMIM:614350
Tuberous Sclerosis 1
Subungual fibromas, Cardiac rhabdomyoma, Astrocytoma, Ependymoma, Optic nerve glioma, Renal cell ... OMIM:191100
Gitelman Syndrome
Parathyroid adenoma, Neoplasm of the pancreas ORPHA:358
Thymic Neuroendocrine Tumor
Neuroendocrine neoplasm, Neoplasm of the thymus, Pituitary adenoma, Carcinoid tumor, Primary hype... ORPHA:97289
Retinoblastoma
Cleft palate, Rhabdomyosarcoma, Leukemia, Leiomyosarcoma, Lymphoma, Ewing sarcoma, Osteosarcoma, ... ORPHA:790
Recurrent Respiratory Papillomatosis
Dysphagia, Squamous cell carcinoma ORPHA:60032
Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Sarcoma, Neoplasm of the breast, Neoplasm of the thyroid gland, Testicular neoplasm ORPHA:457059
Lhermitte-Duclos Disease
Trichilemmoma, Ovarian neoplasm, Macroglossia, Neoplasm of the thyroid gland, Fibroadenoma of the... ORPHA:65285
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Multiple pancreatic beta-cell adenomas, Diffuse pancreatic islet hyperplasia, Elevated circulatin... ORPHA:79644
Dyskeratosis Congenita, Autosomal Dominant 1
Cirrhosis, Myelodysplasia, Squamous cell carcinoma of the skin, Oral leukoplakia OMIM:127550
Blackfan-Diamond Anemia
Malignant genitourinary tract tumor, Myelodysplasia, High palate, Cleft soft palate, Adenocarcino... ORPHA:124
Fanconi Anemia, Complementation Group P
Cryptorchidism, Squamous cell carcinoma OMIM:613951
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:220295
Dyskeratosis Congenita, X-Linked
Myelodysplasia, Hodgkin lymphoma, Carcinoma, Cirrhosis, Acute myeloid leukemia, Esophageal strict... OMIM:305000
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Dysphagia, Spontaneous esophageal perforation, Esophageal stricture, Squamous cell carcinoma, Abn... OMIM:226600
Oculocutaneous Albinism
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:55
Oculocutaneous Albinism Type 2
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79432
Osteogenic Sarcoma
Osteosarcoma, Retinoblastoma OMIM:259500
Papillon-Lefèvre Syndrome
Neoplasm of the skin, Squamous cell carcinoma, Melanoma, Liver abscess ORPHA:678
Tuberous Sclerosis Complex
Cardiac rhabdomyoma, Pancreatic endocrine tumor, Pheochromocytoma, Renal cell carcinoma, Hepatic ... ORPHA:805
Cowden Syndrome 6
High palate, Meningioma, Transitional cell carcinoma of the bladder, Furrowed tongue, Thyroid ade... OMIM:615109
Monosomy 22
High palate, Meningioma, Gonadal neoplasm, Sarcoma, Hepatosplenomegaly, Schwannoma ORPHA:96123
Bloom Syndrome
Leukemia, Cryptorchidism, Squamous cell carcinoma, Lymphoma OMIM:210900
Lmna-Related Cardiocutaneous Progeria Syndrome
Abnormality of the intrahepatic bile duct, Basal cell carcinoma, Squamous cell carcinoma of the s... ORPHA:363618
Neurofibromatosis Type 1
Neoplasm of the skin, Astrocytoma, Meningioma, Plexiform neurofibroma, Spinal neurofibromas, Neop... ORPHA:636
Chromomycosis
Multiple cutaneous malignancies, Squamous cell carcinoma ORPHA:182
Familial Adenomatous Polyposis Due To 5Q22.2 Microdeletion
Osteoma, High palate, Adenomatous colonic polyposis, Desmoid tumors, Hepatoblastoma, Duodenal pol... ORPHA:261584
Neurofibromatosis, Type I
Pheochromocytoma, Astrocytoma, Plexiform neurofibroma, Meningioma, Rhabdomyosarcoma, Spinal neuro... OMIM:162200
17Q11 Microdeletion Syndrome
Pheochromocytoma, Myelodysplasia, Gastrointestinal stroma tumor, Rhabdomyosarcoma, Plexiform neur... ORPHA:97685
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Dominant
Squamous cell carcinoma, Furrowed tongue, Oral leukoplakia OMIM:148210
Hermansky-Pudlak Syndrome
Malabsorption, Gastrointestinal hemorrhage, Basal cell carcinoma, Squamous cell carcinoma of the ... ORPHA:79430
Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb
Plexiform neurofibroma, Spinal neurofibromas, Optic nerve glioma, Lisch nodules, Subcutaneous neu... OMIM:613675
Trichothiodystrophy 1, Photosensitive
Intestinal obstruction, Basal cell carcinoma, Squamous cell carcinoma, Malabsorption OMIM:601675
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Smooth tongue, Squamous cell carcinoma of the skin ORPHA:79396
Glycogen Storage Disease Ic
Hepatomegaly, Chronic pancreatitis, Hepatoblastoma, Hepatocellular carcinoma OMIM:232240
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Dysphagia, Ankyloglossia, Esophageal stricture, Anal fissure, Squamous cell carcinoma, Esophageal... ORPHA:89842
Rothmund-Thomson Syndrome Type 1
Neoplasm of the skin, Myelodysplasia, Leukemia, Functional abnormality of the gastrointestinal tr... ORPHA:221008
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Meningioma, Neoplasm, Intestinal malrotation, Narrow palate, Cryptorchidism, Spinal cord tumor, P... ORPHA:353281
Rothmund-Thomson Syndrome Type 2
Neoplasm of the skin, Cleft palate, Myelodysplasia, High palate, Leukemia, Functional abnormality... ORPHA:221016
Rothmund-Thomson Syndrome, Type 2
High palate, Annular pancreas, Basal cell carcinoma, Osteosarcoma, Squamous cell carcinoma, Anter... OMIM:268400
Tetrasomy 9P
Cleft palate, High palate, Median cleft lip and palate, Bifid uvula, Absent gallbladder, Jaundice... ORPHA:3310
Beckwith-Wiedemann Syndrome
Adrenocortical carcinoma, Hepatomegaly, Gonadoblastoma, Macroglossia, Hepatoblastoma, Pancreatic ... OMIM:130650
Sotos Syndrome
Neuroblastoma, Astrocytoma, Acute lymphoblastic leukemia, Aganglionic megacolon, Cholesteatoma, H... ORPHA:821
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion
High palate, Spinal neurofibromas, Optic nerve glioma, Subcutaneous neurofibromas, Hemangioma, Li... ORPHA:363700
Rothmund-Thomson Syndrome
Neoplasm of the skin, Myelodysplasia, Leukemia, Basal cell carcinoma, Squamous cell carcinoma, Me... ORPHA:2909
Autoimmune Lymphoproliferative Syndrome
Neoplasm of the tongue, Neoplasm of the skin, Hepatomegaly, Thyroid carcinoma, Hodgkin lymphoma, ... ORPHA:3261
Kindler Epidermolysis Bullosa
Dysphagia, Inflammation of the large intestine, Abnormality of the anus, Esophagitis, Esophageal ... ORPHA:2908
Hereditary Acrokeratotic Poikiloderma
Transitional cell carcinoma of the bladder, Xerostomia, Ankyloglossia, Squamous cell carcinoma, O... ORPHA:2907
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
High palate, Meningioma, Intestinal malrotation, Narrow palate, Cryptorchidism, Pilomatrixoma, Ga... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
High palate, Meningioma, Intestinal malrotation, Narrow palate, Cryptorchidism, Pilomatrixoma, Ga... ORPHA:353277
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form
Cutaneous melanoma, Dysphagia, Esophageal ulceration, Ankyloglossia, Anal fissure, Squamous cell ... ORPHA:79408

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tnk1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tnk1.

No publications found that use IMPC mice or data for Tnk1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Tnk1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Tnk1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Tnk1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter